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A Safety and Tolerability Study of VRDN-003 in Participants With Thyroid Eye Disease (TED)

Sponsored by Viridian Therapeutics, Inc.

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Current Status

Active, Not Recruiting

Auto-verified from ClinicalTrials.gov

Verified Dec 18, 2025

Phase

Clinical Trial

Sponsor

Viridian Therapeutics, Inc.

Enrollment Target

284

Start Date

Feb 2025

๐Ÿ“Š
1 of 284 participants interested
0% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This is a clinical trial assessing the safety and tolerability of an investigational drug, VRDN-003, in participants with Thyroid Eye Disease (TED).

Who Can Participate

Inclusion Criteria

Have a clinical diagnosis of TED with or without proptosis and with any CAS (0-7) and in the opinion of the Investigator may benefit from VRDN-003
Not require immediate ophthalmological or orbital surgery in the study eye for any reason.
Must agree to use highly effective contraception as specified in the protocol
Female TED participants must have a negative serum pregnancy test at screening

Exclusion Criteria

Must not have received prior treatment with another anti-IGF-1R therapy
Must not have received systemic corticosteroids for any condition, including TED, or selenium within 2 weeks prior to first dose.
Must not have received other immunosuppressive drugs for any condition, including TED, or any other therapy for TED within 8 weeks prior to first dose
Must not have received an investigational agent for any condition, including TED, within 8 weeks prior to first dose
Must not have received radioactive iodine (RAI) treatment within 8 weeks p

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

284 participants

๐ŸŽ‚

Age Range

18 Years - 75 Years

โšง

Gender

ALL

๐Ÿข

Sponsor

Viridian Therapeutics, Inc.

Study Locations

Choose your preferred location or select flexible during enrollment

Unknown

Tuscon

Arizona

Location available
View Tuscon location page
Unknown

Inglewood

California

Location available
View Inglewood location page
Unknown

Newport Beach

California

Location available
View Newport Beach location page
Unknown

Pasadena

California

Location available
View Pasadena location page
Unknown

Pismo Beach

California

Location available
View Pismo Beach location page
Unknown

Santa Monica

California

Location available
View Santa Monica location page
Unknown

Torrance

California

Location available
View Torrance location page
Unknown

Cape Coral

Florida

Location available
View Cape Coral location page
Unknown

Coral Gables

Florida

Location available
View Coral Gables location page

๐Ÿ“ And 23 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

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Looking for Thyroid Eye Disease Treatment in Tuscon?

Join others in Arizona exploring innovative treatment options through clinical research

Thyroid Eye Disease Treatment Options in Tuscon, Arizona

If you're searching for Thyroid Eye Disease treatment in Tuscon, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Tuscon, Inglewood, Newport Beach and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Thyroid Eye Disease. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Arizona
Now Enrolling
Up to 284 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Thyroid Eye Disease?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Thyroid Eye Disease

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Thyroid Eye Disease Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06812325. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.