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NCT06948422RECRUITINGIRB Ready

A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

Sponsored by Eli Lilly and Company

Quick Self-Assessment

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Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of hypertension in participants with obesity or overweight.

Who Can Participate

Inclusion Criteria

Has systolic blood pressure (SBP) โ‰ฅ 140 mmHg and/or diastolic blood pressure (DBP) โ‰ฅ 90 mmHg (if DBP criteria alone is met, SBP must be โ‰ฅ130 mmHg) at screening (Visit 1).
Has SBP โ‰ฅ 140 mmHg and/or DBP โ‰ฅ 90 mmHg (if DBP criteria alone is met, SBP must be โ‰ฅ130 mmHg) at week 0 (Visit 3).
Untreated for hypertension, or on stable antihypertensive medications โ‰ฅ 30 days prior to Visit 1.
Have a body mass index (BMI) โ‰ฅ 25 kg/mยฒ.

Exclusion Criteria

Has SBP โ‰ฅ170 mmHg and/or DBP โ‰ฅ110 mmHg at Visit 1 or at Visit 3.
Has known secondary causes of hypertension
Have heart failure with reduced ejection fraction (HFrEF) diagnosis
Have had any of the following conditions within 90 days prior to screening.
hospitalization for hypertension or for congestive heart failure
acute coronary syndrome or acute myocardial infarction, or
cerebrovascular accident (stroke).
Have type 1 diabetes (T1D)
Have acute or chronic hepatitis, including a history of autoi

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

974 participants

โšง

Gender

ALL

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Sponsor

Eli Lilly and Company

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

Phoenix

Arizona

Location available
View Phoenix location page
RECRUITING

Covina

California

Location available
View Covina location page
RECRUITING

Northridge

California

Location available
View Northridge location page
RECRUITING

Waterbury

Connecticut

Location available
View Waterbury location page
RECRUITING

Boca Raton

Florida

Location available
View Boca Raton location page
RECRUITING

Brandon

Florida

Location available
View Brandon location page
RECRUITING

Jacksonville

Florida

Location available
View Jacksonville location page
RECRUITING

Port Charlotte

Florida

Location available
View Port Charlotte location page
RECRUITING

St. Petersburg

Florida

Location available
View St. Petersburg location page

๐Ÿ“ And 21 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Looking for Hypertension and Obesity Treatment in Phoenix?

Join others in Arizona exploring innovative treatment options through clinical research

Hypertension and Obesity Treatment Options in Phoenix, Arizona

If you're searching for Hypertension and Obesity treatment in Phoenix, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Phoenix, Covina, Northridge and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Hypertension and Obesity. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Arizona
Now Enrolling
Up to 974 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Hypertension and Obesity?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Hypertension and Obesity

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Hypertension and Obesity Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06948422. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.