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A Study of SPY072 in Rheumatic Disease

(SKYWAY-RD)

Sponsored by Spyre Therapeutics, Inc.

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...

Current Status

Recruiting

Auto-verified from ClinicalTrials.gov

Verified Feb 4, 2026

Phase

Clinical Trial

Sponsor

Spyre Therapeutics, Inc.

Enrollment Target

285

Start Date

Aug 2025

๐Ÿ“Š
1 of 285 participants interested
0% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged โ‰ฅ18 years) with rheumatic disease (RD).

Who Can Participate

Inclusion Criteria

For rheumatoid arthritis:
Moderate-to-severely active RA as defined by the presence of โ‰ฅ4 swollen joints (based on 28 joint count) and โ‰ฅ4 tender joints (based on 28 joint count) at Screening and Day 1.
Documentation of โ‰ฅ1 of the following: 1. Positive test results for rheumatoid factor or anti-citrullinated peptide antibodies at Screening, OR 2. Previous radiographs with bony erosions in hands or feet consistent with RA
Inadequate response (defined as signs and symptoms of persistently active disease, loss of response, or intolerance) to one of the following: 1. โ‰ฅ1 csDMARD treatment; OR 2. 1 bDMARD or 1 tsDMARD treatment (a total of 2 bDMARDs and/or tsDMARDs is

Exclusion Criteria

ary) For axial spondyloarthritis:
Moderate-to-severely active axSpA defined by BOTH of the following at Screening AND Day 1: 1. BASDAI โ‰ฅ4, AND 2. Back pain โ‰ฅ4 (from BASDAI Item 2)
hsCRP greater than the ULN per the central laboratory at Screening - Inadequate response (de

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

285 participants

โšง

Gender

ALL

๐Ÿข

Sponsor

Spyre Therapeutics, Inc.

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

Avondale

Arizona

Location available
View Avondale location page
RECRUITING

Chula Vista

California

Location available
View Chula Vista location page
RECRUITING

Covina

California

Location available
View Covina location page
RECRUITING

Tujunga

California

Location available
View Tujunga location page
RECRUITING

Upland

California

Location available
View Upland location page
RECRUITING

Whittier

California

Location available
View Whittier location page
RECRUITING

Hialeah

Florida

Location available
View Hialeah location page
RECRUITING

Ormond Beach

Florida

Location available
View Ormond Beach location page
RECRUITING

Tampa

Florida

Location available
View Tampa location page

๐Ÿ“ And 4 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Find More Rheumatoid Arthritis Trials by City

Browse all rheumatoid arthritis clinical trials in these cities โ€” not just this study.

Looking for Rheumatoid Arthritis Treatment in Tujunga?

Join others in California exploring innovative treatment options through clinical research

Rheumatoid Arthritis Treatment Options in Tujunga, California

If you're searching for Rheumatoid Arthritis treatment in Tujunga, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Tujunga, Brookline, Tomball and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Rheumatoid Arthritis. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 285 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Rheumatoid Arthritis?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Rheumatoid Arthritis

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Rheumatoid Arthritis Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT07148414. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.