Chicago, ILNCT04707729Now EnrollingIRB Ready

Acute Hypoxemic Respiratory Failure Clinical Trial in Chicago, IL

Access cutting-edge acute hypoxemic respiratory failure treatment through this clinical trial at a research site in Chicago. Study-provided care at no cost to qualified participants.

Sponsored by Hospital Universitari Vall d'Hebron Research Institute

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Expert Care in Chicago

Access acute hypoxemic respiratory failure specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related acute hypoxemic respiratory failure treatment provided free

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Check if you qualify for this acute hypoxemic respiratory failure clinical trial in Chicago, IL

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Why Participate?

  • No-Cost Study Care

  • Local to Chicago

    Convenient for IL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Chicago site if eligible
  4. 4Begin participation

About This Acute Hypoxemic Respiratory Failure Study in Chicago

Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality. The ROX index has been designed and validated to predict outcome of NFH therapy by identifying those patients with a high risk of NHF failure and those with a high probability of success. Whether or not the ROX index may improve patient outcome remains to be shown. To do so, a strategy using the ROX index must lead to earlier intubation than commonly-used criteria. The objective of the ROX-1 trial is to assess whether the use of an algorithm incorporating the ROX index to standard of care for the time to intubation in patients with AHRF supported with NHF isassociated with an increase in the proportion of patients who are intubated within the first 12 hours among those patients who fail on NHF.

Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Who Can Participate

Inclusion Criteria

All consecutive patients older than 18 years with acute hypoxemic respiratory failure who need to be supported with nasal high flow (NHF) will be considered for inclusion.
Criteria for initiation of NHF if they had a respiratory rate \> 25 breaths/min and/or pulse oximetry (SpO2) \< 92% while receiving standard oxygen administered through a facemask at 10 L/mn or more.
Patients already treated with NHF for acute respiratory failure prior to ICU admission will be enrolled if duration of NHF prior to randomization does not exceed one hour.

Exclusion Criteria

Patients younger than 18 years old.
Patients with indication for immediate intubation.
Patients treated with NHF for more than 1h prior to randomization.
Patients with do-not-intubate order.
Patients electively intubated for diagnostic or therapeutic procedures. (fibrobronchoscopy, surgery).
Patients with no pulmonary infiltrates on chest X-ray
Patient with post-extubation AHRF.
Awake ECMO.
Refusal to participate or participation in another interventional study with the same primary outcome.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Chicago?

Yes, this clinical trial (NCT04707729) has an active research site in Chicago, IL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Acute Hypoxemic Respiratory Failure Treatment Options in Chicago, IL

If you're searching for acute hypoxemic respiratory failure treatment options in Chicago, IL, this clinical trial (NCT04707729) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Chicago research site is actively enrolling participants for this clinical trial. You'll receive care from experienced acute hypoxemic respiratory failure specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all acute hypoxemic respiratory failure clinical trials near you to find additional studies recruiting in your area.

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