Houston, TXNCT06634394Now EnrollingIRB Ready

Acute Myeloid Leukemia (AML) Clinical Trial in Houston, TX

Access cutting-edge acute myeloid leukemia (aml) treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by Aptevo Therapeutics

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Expert Care in Houston

Access acute myeloid leukemia (aml) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related acute myeloid leukemia (aml) treatment provided free

Apply for This Houston Location

Check if you qualify for this acute myeloid leukemia (aml) clinical trial in Houston, TX

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Acute Myeloid Leukemia (AML) Study in Houston

A multi-center, open-label, dose-finding study of five dose levels of APVO436 in combination with venetoclax and azacitidine (ven/aza) in adult patients with newly diagnosed, CD123+ AML.

Sponsor: Aptevo Therapeutics

Who Can Participate

Inclusion Criteria

1\. Age ≥18 years. 2. Patient must have confirmation of AML based on 2016 World Health Organization (WHO) criteria and not been previously treated. 3\. Patients must have CD123-positive AML as confirmed by local flow cytometry (or immunohistochemistry \[IHC\]). Confirmation at diagnosis is acceptable. 4\. Patient must be considered ineligible for induction therapy defined by at least one of the following:
≥75 years of age
Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 or 3
Cardiac disorder (e.g., congestive heart failure requiring treatment, ejection fraction ≤ 50%, or chronic stable angina)
Pulmonary disorder (e.g., DLCO ≤65% or FEV1 ≤65%)
Creatinine clearance 30-45 mL/min based on Cockcroft-Gault or Modified of Diet in Renal Disease (MDRD) formular
Hepatic disorder with total bilirubin between 1.5 and 3 times the ULN 5. Patient must have a projected life expectancy of ≥12 weeks

Exclusion Criteria

Patient has received treatment with the following:
A hypomethylating agent, venetoclax, and/or chemotherapeutic agent for AML, myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), or myelodysplastic/myeloproliferative neoplasms (MPS/MPN)
CAR-T cell therapy or history of allogeneic hematopoietic stem cell transplant (HSCT)
Experimental therapies for MDS or AML
Patient is currently participating in another interventional research study.
Patient has history of MPN including myelofibrosis, essential thrombocythemia, polycythemia vera, chronic myeloid leukemia (CML) with or without BCR-ABL1 translocation, or AML with BCR-ABL1 translocation.
Patient has acute promyelocytic leukemia.
Patient has a current autoimmune disorder requiring immunosuppressive therapy such as systemic (oral or IV) steroid therapy \>10 mg methylprednisolone daily or its equivalent
Patient is receiving concurrent corticosteroid therapy as an anticancer drug (any dose).
Patient has known active CNS involvement with AML. Patients who received intrathecal chemotherapy for prophylaxis of AML in the CNS prior to enrollment may enroll in this study.
Creatinine clearance \<30ml/min based on Cockcroft-Gault or MDRD formular.
Bilirubin of \>3xULN in the absence of Gilbert's Syndrome.
AST and/or ALT \>3 times the ULN.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT06634394) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Acute Myeloid Leukemia (AML) Treatment Options in Houston, TX

If you're searching for acute myeloid leukemia (aml) treatment options in Houston, TX, this clinical trial (NCT06634394) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced acute myeloid leukemia (aml) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all acute myeloid leukemia (aml) clinical trials near you to find additional studies recruiting in your area.

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