Nashville, TNNCT07175441Now EnrollingIRB Ready

Advanced Unresectable Hepatocellular Carcinoma Clinical Trial in Nashville, TN

Access cutting-edge advanced unresectable hepatocellular carcinoma treatment through this clinical trial at a research site in Nashville. Study-provided care at no cost to qualified participants.

Sponsored by Riboscience, LLC.

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Expert Care in Nashville

Access advanced unresectable hepatocellular carcinoma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related advanced unresectable hepatocellular carcinoma treatment provided free

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Check if you qualify for this advanced unresectable hepatocellular carcinoma clinical trial in Nashville, TN

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Nashville

    Convenient for TN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Nashville site if eligible
  4. 4Begin participation

About This Advanced Unresectable Hepatocellular Carcinoma Study in Nashville

RBS2418 is a targeted immune modulator that inhibits ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). It is designed to promote anti-tumor immunity by preserving endogenous 2'-3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from hydrolysis, thereby activating antigen-presenting cells and promoting robust T cell activation. Ideally, RBS2418 acts synergistically with CTLA-4 inhibitors, such as those in the STRIDE regimen (Tremelimumab plus Durvalumab). The hypothesis is that RBS2418 combined with STRIDE will be safe, well-tolerated, highly immunogenic, and enhance anti-tumor responses in adult participants with advanced, unresectable hepatocellular carcinoma (HCC) compared to STRIDE alone.

Sponsor: Riboscience, LLC.

Who Can Participate

Inclusion Criteria

At least 18 years of age on the day of signing informed consent.
Male and female participants with advanced, unresectable HCC who are eligible to receive STRIDE regimen as first line therapy.
Willing to submit a pre-treatment tissue sample (archival or fresh tissue if archival is not available).

Exclusion Criteria

BCLC stage D disease at the time of screening or prior to first dose of RBS2418.
Child-Pugh class equal or higher than B8 at the time of screening or within 7 days prior to the first dose of study treatment.
Eligible for curative treatments (e.g., surgical resection, liver transplantation, or local ablation).
Evidence of rapid progression on prior therapy resulting in rapid clinical deterioration.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Nashville?

Yes, this clinical trial (NCT07175441) has an active research site in Nashville, TN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Advanced Unresectable Hepatocellular Carcinoma Treatment Options in Nashville, TN

If you're searching for advanced unresectable hepatocellular carcinoma treatment options in Nashville, TN, this clinical trial (NCT07175441) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Nashville research site is actively enrolling participants for this clinical trial. You'll receive care from experienced advanced unresectable hepatocellular carcinoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all advanced unresectable hepatocellular carcinoma clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Nashville, TN