Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Liver Cancer Clinical Trials
Liver Cancer clinical trials are recruiting across 132 cities. Here are the cities with the most active studies:
Liver Cancer Trial Phases
75 research organizations are sponsoring liver cancer trials.
About Liver Cancer
Liver cancer most commonly presents as hepatocellular carcinoma (HCC) and is often associated with chronic liver disease or hepatitis. It is one of the fastest-growing causes of cancer death. Treatment options include surgery, liver transplant, ablation, and systemic therapies.
Clinical trials are advancing new treatments for liver cancer. Currently, 100 studies are recruiting a combined 29,280 participants across the United States. Research is being conducted by 75 organizations including University of Texas Southwestern Medical Center, VA Office of Research and Development, University of Pittsburgh and 72 others.
2026 Liver Cancer Research Landscape
As of July 2026, the liver cancer clinical trial landscape includes 100 actively recruiting studies across 132 cities in the United States. These studies are collectively seeking 29,280 participants, with an average enrollment target of 293 per study.
The research spans multiple phases of development: 48 studies are in PHASE2, 37 studies are in PHASE1, 16 studies are in NA, 4 studies are in PHASE3, 3 studies are in PHASE4. The presence of Phase 3 trials indicates that some liver cancer treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 75 different organizations, including University of Texas Southwestern Medical Center, VA Office of Research and Development, University of Pittsburgh, M.D. Anderson Cancer Center, AstraZeneca, and 70 others. The large number of sponsors reflects significant research interest and investment in liver cancer treatment advancement.
Geographically, liver cancer trials are most concentrated in Houston, Texas (20 trials); Los Angeles, California (14 trials); Chicago, Illinois (11 trials); New York, New York (11 trials); Duarte, California (10 trials) and 7 other cities.
Featured Liver Cancer Studies
Highlighted recruiting studies for liver cancer, selected by enrollment size and research scope.
National Liver Cancer Screening Trial
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using ...
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at e...
Molecular Basis of Pediatric Liver Cancer
The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
Frequently Asked Questions About Liver Cancer Clinical Trials
Are there liver cancer clinical trials near me?
Yes, there are 100 liver cancer clinical trials currently recruiting across 132+ cities in the United States, including Houston, Texas; Los Angeles, California; Chicago, Illinois. Browse the studies above to find one at a location convenient for you.
How do I join a liver cancer clinical trial?
To join a liver cancer clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are liver cancer clinical trials free?
Yes, participation in liver cancer clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of liver cancer treatments are being studied?
Current liver cancer clinical trials are testing a range of approaches across PHASE2 (48 studies), PHASE1 (37 studies), NA (16 studies), PHASE3 (4 studies), PHASE4 (3 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 75 research organizations.
Is it safe to participate in liver cancer clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov