Portland, ORNCT06426303Now EnrollingIRB Ready

Alcohol Use Disorder Clinical Trial in Portland, OR

Access cutting-edge alcohol use disorder treatment through this clinical trial at a research site in Portland. Study-provided care at no cost to qualified participants.

Sponsored by Milky Kohno

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Expert Care in Portland

Access alcohol use disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related alcohol use disorder treatment provided free

Apply for This Portland Location

Check if you qualify for this alcohol use disorder clinical trial in Portland, OR

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Portland

    Convenient for OR residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Portland site if eligible
  4. 4Begin participation

About This Alcohol Use Disorder Study in Portland

The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder. The main questions it aims to answer are: * How does trauma affect emotion regulation, inflammation, and limbic function, and what are the sex-dependent effects of NTX (Naltrexone) on these aspects? * What is the mechanism of Naltrexone (NTX), and how does it potentially moderate reductions in alcohol use through changes in or interactions between emotion regulation, inflammation, or limbic system function? Participants will * Be consented and will undergo comprehensive screening for eligibility criteria * Complete behavioral assessments and neuropsychological assessments, as well as neurocognitive assessments and neuroimaging measures * Provide urine samples for a urine drug screen (UDS) and urine pregnancy test (for women), and have blood and a cheek swab collected and stored in the repository * Take a study drug once daily for 12 weeks and track drug usage and effects in a study journal * Undergo weekly assessment calls and bi-weekly medical follow-up safety exams Researchers will compare naltrexone to placebo in AUD to see if naltrexone is effective in reducing alcohol cravings and promoting abstinence. Researchers will also compare baseline measures between AUD and Healthy Controls.

Sponsor: Milky Kohno

Who Can Participate

Inclusion Criteria

18-60 years old
Veteran enrolled in VHA healthcare Alcohol Group:
must meet diagnosis for recent alcohol-use disorder (DSM-V)
willing to return for follow-up visits and can participate for 12-weeks Control Group:
must not meet DSM-V criteria for a use disorder other than nicotine

Exclusion Criteria

Clinically significant neurological, endocrine, hepatic, or systemic disease that would compromise safe participation or confound outcomes
Left-handedness
Axis-1 psychiatric diagnoses other than anxiety, depression or post-traumatic stress disorder
Recreational or prescriptive use of psychotropic medications
Recreational or prescriptive use of opioid medications or have a past or current history of abuse or dependence on opioids
MRI contraindications (e.g. metal in body)
Positive urine drug screen, except for nicotine and marijuana, on test days
Women who are pregnant or breastfeeding
Participants on hormonal therapy or treatments other than pregnancy contraceptives
Autoimmune or neurodegenerative diseases that present with neuroinflammation (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's, Parkinson's)
Current participation in an investigational drug study
Alcohol group: \< 5 days and \> 3 weeks of abstinence from alcohol
Alcohol group: Liver disease requiring medication or medical treatment, and/or aspartate or alanine aminotransferase levels greater than 3 times the upper limit of normal, gastrointestinal or renal disease that would significantly impair absorption, metabolism or excretion of study drug, or require medical treatment.
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Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Portland?

Yes, this clinical trial (NCT06426303) has an active research site in Portland, OR that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alcohol Use Disorder Treatment Options in Portland, OR

If you're searching for alcohol use disorder treatment options in Portland, OR, this clinical trial (NCT06426303) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Portland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced alcohol use disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alcohol use disorder clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Portland, OR