Charlottesville, VANCT06600178Now EnrollingIRB Ready

Angina Patients With Non-obstructive Coronary Artery Disease Clinical Trial in Charlottesville, VA

Access cutting-edge angina patients with non-obstructive coronary artery disease treatment through this phase 1 clinical trial at a research site in Charlottesville. Study-provided care at no cost to qualified participants.

Sponsored by University of Virginia

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Expert Care in Charlottesville

Access angina patients with non-obstructive coronary artery disease specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related angina patients with non-obstructive coronary artery disease treatment provided free

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Check if you qualify for this angina patients with non-obstructive coronary artery disease clinical trial in Charlottesville, VA

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Why Participate?

  • No-Cost Study Care

  • Local to Charlottesville

    Convenient for VA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charlottesville site if eligible
  4. 4Begin participation

About This Angina Patients With Non-obstructive Coronary Artery Disease Study in Charlottesville

The goal of this clinical trial is to that Sodium-glucose cotransporter 2 inhibitors treatment will improve Coronary Microvascular Disease with anginal symptoms associated with non-obstructive coronary disease in women. The main questions it aims to answer are: Aim 1: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves coronary microvascular disease in women with no evidence of epicardial obstructive coronary artery disease. Aim 2: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves angina symptoms and other quality of life measurements associated with the improvement of CFR. AIM 3: Identify the effect of Sodium-glucose cotransporter 2 inhibition on inflammation pathways and markers of systemic Research will compare Brezavvy to placebo Participants will: * Take study drug or placebo for 12 weeks * Stress Cardiac magnetic resonance imaging * 12 lead electrocardiograms * Complete questionnaires

Sponsor: University of Virginia

Who Can Participate

Inclusion Criteria

• Female sex.
Age ≥18 years.
Willing and able to provide written informed consent.
Signs and symptoms of suspected ischemia prompted referral for further evaluation by cardiac catheterization or CCTA within two years of consent.
No evidence of obstructive epicardial CAD (stenosis \<50%) of a major epicardial vessel or an FFR ≤0.80 by invasive catheterization or CCTA. Patients who have not undergone cardiac catheterization of CT angiogram within the last 2 years for chest pain can be scheduled for a screening CT angiogram of the coronary arteries to confirm eligibility.
Diagnosis of CMD defined by CFR \&lt; 2 by CMR
Never on SGLT2i

Exclusion Criteria

History of non-ischemic cardiomyopathy LVEF \<40% or hypertrophic cardiomyopathy.
History of congestive heart failure, severe pulmonary disease, liver disease
History of acute coronary syndrome (ACS) within previous 30 days
Stroke within the last 180 days or intracranial hemorrhage at any time.
Severe valvular disease
Life expectancy \<3 years, due to non-cardiovascular comorbidity.
Pregnancy or women who are breast-feeding
Type 1 diabetes mellitus
Symptomatic hypotension or systolic BP \>95 mmHg on 2 consecutive measurements
Active malignancy requiring treatment at the time of visit
Severe (eGFR \<30 mL/min/1.73 m2 by CKD-EPI), unstable, or rapidly progressing renal disease at the time of randomization
History of recurrent UTI/bladder/kidney infections
Asthma with ongoing wheezing
Known or suspected broncho-constrictive or bronchospastic lung disease (ARDS, emphysema)
Greater than first degree heart block
Implanted cardiac device
Profound sinus bradycardia (heart rate \<40 beats per minute)
Atrial fibrillation or supraventricular arrhythmias at time of imaging
Known intolerance of nitrates (other than hypotension)
History of reaction to iodinated contrast agents

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charlottesville?

Yes, this clinical trial (NCT06600178) has an active research site in Charlottesville, VA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Angina Patients With Non-obstructive Coronary Artery Disease Treatment Options in Charlottesville, VA

If you're searching for angina patients with non-obstructive coronary artery disease treatment options in Charlottesville, VA, this clinical trial (NCT06600178) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charlottesville research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced angina patients with non-obstructive coronary artery disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all angina patients with non-obstructive coronary artery disease clinical trials near you to find additional studies recruiting in your area.

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