Is NCT05671757 recruiting in Rochester, MN?

Yes, NCT05671757 is currently recruiting participants at its Rochester, MN location. This antiphospholipid syndrome clinical trial is actively enrolling qualified participants.

How do I join the antiphospholipid syndrome clinical trial in Rochester?

To join this clinical trial in Rochester, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Rochester clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Antiphospholipid Syndrome Clinical Trial in Rochester, MN

About This Antiphospholipid Syndrome Study in Rochester

The purpose of this study is to see if the study medication, daratumumab, is safe to treat individuals with Anti-Phospholipid Syndrome (APS). Three daratumumab dosing cohorts are planned with up to six participants in each dosing cohort with the potential to enroll an additional 4 subjects in the highest safe dose (HSD) cohort, for a total of up to 22 participants. The dosing cohorts are: 4 mg/kg, 8 mg/kg, and 16 mg/kg. Each cohort will receive intravenous (IV) administration of daratumumab acc

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Who Can Participate

Inclusion Criteria

Adults 18 to 70 years of age, inclusive.

The completion of the following vaccinations at least 14 days prior to Visit 0:

At least one dose of the most recently updated COVID-19 vaccine, and

At least one dose of the herpes zoster vaccination series, and

Current seasonal influenza vaccine, if available.

History of APS according to the updated 2006 Sapporo classification criteria, including at least one of the following: a. Arterial thrombosis, except transient ischemic attack, confirmed by objective validated criteria such as imaging, or b. Venous thrombosis, except superficial thrombophlebitis, confirmed by objective validated criteria such as imaging, or c. Pregnancy morbidity, based on the updated 2006 Sapporo APS classification criteria, or d. Microvascular APS, with at least one of the following: i. Renal biopsy documentation of aPL-associated nephropathy, or ii. Lung biopsy or bronchoalveolar lavage documentation of diffuse alveolar hemorrhage (DAH), or iii. Skin biopsy documentation of livedoid vasculopathy.

History of triple positive aPL within the prior 5 years and at least 12 weeks prior to enrollment, including all of the following:

aCL IgG level \> Upper Limit of Normal (ULN), and

aβ2GPI IgG level \> ULN, and

Positive LA test.

Confirmation of triple positive aPL at screening, including all of the following:

aCL IgG level ≥ 40 GPL, and

aβ2GPI IgG level ≥ 40 SGU, and

Positive LA test.

Undergoing anticoagulation with warfarin or low molecular weight heparin (LMWH), if there is a history of arterial or venous thrombosis.

Exclusion Criteria

Inability or unwillingness to give written informed consent.

Inability or unwillingness to comply with study protocol.

Systemic autoimmune diseases other than APS, including but not limited to:

Systemic lupus erythematosus (SLE) meeting the EULAR/ACR classification criteria.

Rheumatoid arthritis meeting the ACR/EULAR classification criteria.

Small, medium, and large vessel vasculitis meeting ACR classification criteria.

Catastrophic APS classification within the prior 90 days.

Acute arterial or venous thrombosis within the prior 30 days.

Use of the following medications:

Any prior treatment with CD38 targeting monoclonal antibodies, including daratumumab or isatuximab-irfc.

The following within the prior 30 days: i. Corticosteroids \> 10 mg/day prednisone or equivalent. ii. Direct oral anticoagulants (DOACs). iii. Live attenuated vaccines. iv. IVIG or other supplemental immunoglobulin. c. Azathioprine, methotrexate, mycophenolate mofetil, mycophenolate sodium, lefluonomide, or calcineurin inhibitors within the prior 90 days. d. Cyclophosphamide within the prior 90 days. e. Immunomodulatory or immunosuppressive biologic agents, including belimumab, within the prior 90 days or 5 half-lives, whichever is greater. f. Investigational agents within the prior 90 days or 5 half-lives, whichever is greater, except for COVID-19 vaccines and medications for prevention or treatment of COVID-19 per FDA Emergency Use Authorization (EUA). g. Biologic B cell depleting agents including rituximab with any of the following: i. Treatment within the prior 180 days, or ii. CD19+ absolute count \< 40/ μl, or iii. Serum IgG \<500 mg/dL.

Plasma exchange within the prior 90 days.

Hemodialysis within the prior 90 days.

Major surgical procedure within the prior 60 days.

Known allergy, hypersensitivity, or intolerance to boron, malitol, sorbitol, corticosteroids, monoclonal antibodies including daratumumab, human proteins, or their excipients.

Allergy, intolerance, or contraindication to acyclovir, valacyclovir, and famciclovir.

Active or chronic infection, including the following:

Active bacterial, viral, fungal, or opportunistic infection.

Chronic infection requiring suppressive antibiotic treatment.

Intravenous antibiotics or hospitalization for infection within the prior 30 days.

Evidence of current or prior Mycobacterium tuberculosis infection.

Human immunodeficiency virus (HIV).

Current or prior infection with hepatitis B virus (HBV).

Current or prior infection with hepatitis C virus (HCV), except adequately treated HCV with sustained virologic response ≥ 12 weeks.

History of recurrent herpes zoster, or history of herpes zoster ophthalmicus, disseminated herpes zoster, or disseminated herpes simplex.

The following laboratory abnormalities: ITN093AI: DARE-APS Version 3.0 September 12, 2023 Daratumumab in Primary Antiphospholipid Syndrome

Absolute neutrophil count \< 1500/mm3.

Platelets \< 100,000/mm3.

Hemoglobin (Hgb) \< 10 g/dL.

Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or alkaline phosphatase \> 2x the Upper Limit of Normal (ULN).

Total bilirubin \> 2x ULN, except in the case of congenital bilirubinemia then direct bilirubin \> 2x ULN.

eGFR \< 45 ml/min/1.73 m2.

History of primary immunodeficiency.

History of solid organ or hematopoietic stem cell transplantation.

Comorbidities requiring systemic corticosteroid therapy, including those which have required three or more courses of systemic corticosteroids within the 12 months prior to Visit 0.

Any of the following conditions with FEV1 \< 70% predicted within the prior 90 days:

Chronic obstructive pulmonary disease (COPD).

Pulmonary hypertension.

Adrenal insufficiency.

Poorly controlled diabetes mellitus defined as hemoglobin A1c (HbA1c) ≥ 8.0%.

Concomitant malignancy or history of malignancy, except adequately treated or excised nonmetastatic squamous cell carcinoma, basal cell skin carcinoma, or cervical carcinoma in situ.

Clinically significant cardiac disease, including but not limited to:

Myocardial infarction within the prior 6 months, or

Unstable or uncontrolled disease or condition related to or affecting cardiac function, including but not limited to: i. Unstable angina, or ii. Congestive heart failure, New York Heart Association Class II-IV, or iii. Uncontrolled cardiac arrhythmia.

Current diagnosed mental illness or current diagnosed or self-reported drug or alcohol abuse which, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.

Severe, progressive, or uncontrolled renal, hepatic, hematological, gastrointestinal, pulmonary, cardiac, or neurological disease.

Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements, or may impact the quality or interpretation of the data obtained from the study.

Lack of peripheral venous access.

Pregnancy, or planning a pregnancy during the 48 week study duration.

Breast-feeding.

Unwillingness to use medically acceptable non-prothrombotic contraception if of reproductive potential and engaging in sexual activity that could lead to pregnancy.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Rochester?

Yes, this clinical trial (NCT05671757) has an active research site in Rochester, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Antiphospholipid Syndrome Treatment Options in Rochester, MN

If you're searching for antiphospholipid syndrome treatment options in Rochester, MN, this clinical trial (NCT05671757) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Rochester research site is actively enrolling participants for this phase 1/2 clinical trial. You'll receive care from experienced antiphospholipid syndrome specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all antiphospholipid syndrome clinical trials near you to find additional studies recruiting in your area.

Antiphospholipid Syndrome Clinical Trial in Rochester, MN

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