IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy
This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with antiphospholipid...
Daratumumab in Primary Antiphospholipid Syndrome
The purpose of this study is to see if the study medication, daratumumab, is safe to treat individuals with Anti-Phospholipid Syndrome (APS). Three daratumumab dosing cohorts are planned with up to s...
Top Cities for Antiphospholipid Syndrome Clinical Trials
Antiphospholipid Syndrome clinical trials are recruiting across 8 cities. Here are the cities with the most active studies:
About Antiphospholipid Syndrome
Antiphospholipid syndrome is an autoimmune disorder that increases the risk of blood clots in arteries and veins, and pregnancy complications. It occurs when the immune system makes antibodies that attack phospholipids. Treatment primarily involves anticoagulant medications.
Clinical trials are advancing new treatments for antiphospholipid syndrome. Currently, 2 studies are recruiting a combined 77 participants across the United States. Research is being conducted by 2 organizations including David Ware Branch, National Institute of Allergy and Infectious Diseases (NIAID).
2026 Antiphospholipid Syndrome Research Landscape
As of March 2026, the antiphospholipid syndrome clinical trial landscape includes 2 actively recruiting studies across 8 cities in the United States. These studies are collectively seeking 77 participants, with an average enrollment target of 39 per study.
Research is being led by 2 different organizations, including David Ware Branch, National Institute of Allergy and Infectious Diseases (NIAID).
Geographically, antiphospholipid syndrome trials are most concentrated in New York, New York (4 trials); Salt Lake City, Utah (1 trial); Toronto, Ontario (1 trial); Baltimore, Maryland (1 trial); Ann Arbor, Michigan (1 trial) and 3 other cities.
Featured Antiphospholipid Syndrome Studies
Highlighted recruiting studies for antiphospholipid syndrome, selected by enrollment size and research scope.
IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy
This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with antiphospholipid syndrome (APS) and repeatedly positive tests for lupus anticoagulant (LAC) to determine if this regimen will improve pregnancy outcomes. All enrolled patients will receive certolizumab, and pregnancy...
Daratumumab in Primary Antiphospholipid Syndrome
The purpose of this study is to see if the study medication, daratumumab, is safe to treat individuals with Anti-Phospholipid Syndrome (APS). Three daratumumab dosing cohorts are planned with up to six participants in each dosing cohort with the potential to enroll an additional 4 subjects in the highest safe dose (HSD) cohort, for a total of up to 22 participants. The dosing cohorts are: 4 mg/kg...
Frequently Asked Questions About Antiphospholipid Syndrome Clinical Trials
Are there antiphospholipid syndrome clinical trials near me?
Yes, there are 2 antiphospholipid syndrome clinical trials currently recruiting across 8+ cities in the United States, including New York, New York; Salt Lake City, Utah; Toronto, Ontario. Browse the studies above to find one at a location convenient for you.
How do I join a antiphospholipid syndrome clinical trial?
To join a antiphospholipid syndrome clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are antiphospholipid syndrome clinical trials free?
Yes, participation in antiphospholipid syndrome clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of antiphospholipid syndrome treatments are being studied?
Current antiphospholipid syndrome clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 2 research organizations.
Is it safe to participate in antiphospholipid syndrome clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov