NCT06919900 · Georgia State University
Motor Learning of Fall Resistant Skills Through Slip and Trip Exposure in Multiple Sclerosis
(STRES-MS)
What this study is about
The primary purpose of this interventional study is to examine the overall motor learning capacity from exposure to repeated perturbations among ambulatory people with multiple sclerosis (MS). This project will advance our understanding of learning new motor skills from exposure to external perturbations.
View original scientific description
The primary purpose of this interventional study is to examine the overall motor learning capacity from exposure to repeated perturbations among ambulatory people with multiple sclerosis (MS). This project will advance our understanding of learning new motor skills from exposure to external perturbations. If it is proven that people with MS can learn motor skills from perturbation training, the findings from this study will pave a theoretical foundation for applying perturbation training as a promising fall prevention intervention for people with MS.
Interventions
BEHAVIORAL
Perturbation Training
Unexpected slips blended with trips and unperturbed walking trials on a treadmill. A safety harness will be worn at all times.
BEHAVIORAL
Treadmill Walking
Treadmill walking for the same amount of time as the training group without perturbation. A safety harness will be worn at all times.
Primary outcome measures
Perturbation Outcome (Fall or Non-Fall) on the Treadmill or Overground
Time frame: Baseline (acquisition session), 3-month retention session, 6-month retention session.
A loadcell will be connected to the safety harness (above the participant's head) and will measure the force exerted on the safety harness during each perturbation trial. Perturbation outcomes will be classified as falls if the peak loadcell force exceeds 30% of the body weight. Otherwise, perturbation outcomes will be classified as non-falls.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Clinically confirmed multiple sclerosis
- At least 45 years old
- Able to walk independently at least 25 feet
- Able to stand independently for at least 30 seconds
- Patient Determined Disability Steps score between 0 and 4
- Free from pregnancy
- Montreal Cognitive Assessment score of 23 or higher
Exclusion criteria
- Previous experience with perturbation training
- T-score from the dual x-ray absorptiometry (DXA) scan of less than -2.5
- Coexisting psychiatric disorders or other neurological conditions, severe medical illness, or cardiovascular diseases
- Participants have had a relapse in the past 8 weeks
Where
- Atlanta, Georgia
Collaborators
National Multiple Sclerosis Society
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 17, 2026 · Source of record for eligibility and locations