Philadelphia, PANCT06545084Now EnrollingIRB Ready

Apical Periodontitis Clinical Trial in Philadelphia, PA

Access cutting-edge apical periodontitis treatment through this clinical trial at a research site in Philadelphia. Study-provided care at no cost to qualified participants.

Sponsored by University of Pennsylvania

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Expert Care in Philadelphia

Access apical periodontitis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related apical periodontitis treatment provided free

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Check if you qualify for this apical periodontitis clinical trial in Philadelphia, PA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Philadelphia

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Philadelphia site if eligible
  4. 4Begin participation

About This Apical Periodontitis Study in Philadelphia

The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.

Sponsor: University of Pennsylvania

Who Can Participate

Inclusion Criteria

Provision of signed and dated informed consent form.
Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits.
Male or Female age \>18 years old.
In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery.
Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5)
Intact coronal restorations with no evidence of leakage or caries under the restoration.

Exclusion Criteria

Suspected root fractures.
ASA classification 3 or greater.
Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5).
Patients with history of Oral or IV Bisphosphonate use.
Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT06545084) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Apical Periodontitis Treatment Options in Philadelphia, PA

If you're searching for apical periodontitis treatment options in Philadelphia, PA, this clinical trial (NCT06545084) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced apical periodontitis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all apical periodontitis clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Philadelphia, PA