Philadelphia, PA45 Active Studies

Pulmonary Embolism Clinical Trials in Philadelphia, PA

Find 45 actively recruiting pulmonary embolism clinical trials in Philadelphia, PA. Connect with local research sites and explore new treatment options.

45
Active Trials
32
Sponsors
11,754
Enrolling

Recruiting Pulmonary Embolism Studies in Philadelphia

NCT06245057Recruiting

Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity

The goal of this randomized controlled intervention trial is to evaluate an integrated, interdisciplinary, multi-level maternity care home model (MCHM) aimed at reducing severe maternal morbidity (SMM...

Philadelphia, PANA2,300 participantsUniversity of Pennsylvania
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NCT06062394Recruiting

Penn Medicine Healthy Heart

To leverage access to patients across the primary care network, EPIC tools for identifying eligible patients, and the Way to Health platform to launch and enroll a program that will be evaluated in a ...

Philadelphia, PANA1,980 participantsUniversity of Pennsylvania
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NCT04815005Recruiting

HoFH, the International Clinical Collaborators Registry

Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low-density lipo...

Philadelphia, PA1,000 participantsUniversity of Pennsylvania
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NCT07209254Recruiting

Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension

A multicenter randomized trial that will compare the effectiveness of two postpartum blood pressure (BP) management strategies in improving blood pressure and cardiac function and increasing patient e...

Philadelphia, PANA770 participantsJennifer Lewey, MD, MPH
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NCT05470205Recruiting

Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal

This is an open-label, non-randomized trial that will be conducted at three clinical sites, Thomas Jefferson University (TJU), the Hospital of the University of Pennsylvania (HUP) and University of Be...

Philadelphia, PAPHASE3660 participantsThomas Jefferson University
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NCT06994442Recruiting

Optimizing Pain Treatment in Children On Mechanical Ventilation

In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help wit...

Philadelphia, PAPHASE3644 participantsWeill Medical College of Cornell University
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NCT06628453Recruiting

CGM for Management of Type 2 Diabetes in Pregnancy

The goal of this clinical trial is to learn if continuous glucose monitoring works better than self-monitoring of blood glucose (fingersticks) to treat type 2 diabetes in pregnancy. It will also learn...

Philadelphia, PANA564 participantsUniversity of Alabama at Birmingham
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NCT06121011Recruiting

A Global Prospective Observational Registry of Patients With Pompe Disease

This is a global, multicenter, prospective, observational registry of patients with Pompe disease, including those with late-onset pompe disease (LOPD) and infantile-onset pompe disease (IOPD). Both u...

Philadelphia, PA500 participantsAmicus Therapeutics
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NCT07481981Recruiting

A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)

The primary objective of this study is to evaluate the effect of 24-weeks of once daily treatment with TPIP compared with placebo on exercise capacity in adults with PAH....

Philadelphia, PAPHASE3344 participantsInsmed Incorporated
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NCT07218016Recruiting

Accelerometer Measured Early Recovery After Prolapse Surgery

The AccelERate study will evaluate the physical recovery of patients who have undergone Pelvic Organ Prolapse (POP) surgery. This will be evaluated via a self-reported recovery questionnaire completed...

Philadelphia, PANA288 participantsNICHD Pelvic Floor Disorders Network
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NCT06670001Recruiting

MOVE-HF MOtivating Physical Activity With BehaVioral Economics in Heart Failure With Preserved Ejection Fraction

This is a three-arm, randomized, controlled trial to test the effectiveness of gamification plus a social incentive - either social support or competition - to increase adherence to physical activity ...

Philadelphia, PANA270 participantsUniversity of Pennsylvania
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NCT02780297Recruiting

Prospective Research Rare Kidney Stones (ProRKS)

The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and aden...

Philadelphia, PA220 participantsMayo Clinic
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NCT07167004Recruiting

The GRoceries Aimed at Increasing Nutrition Study

Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes. This study aims to assess if consumers with prediabetes or ty...

Philadelphia, PANA216 participantsUniversity of Pennsylvania
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NCT06588634Recruiting

The PERSEVERE Study

Randomized Controlled Trial of High-Risk Pulmonary Embolism Comparing FlowTriever System vs. Standard of Care...

Philadelphia, PANA200 participantsInari Medical
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NCT06712823Recruiting

An Extension Study to Evaluate Safety and Efficacy in Participants Treated With CRN04894

The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of atumelnant (CRN04894)....

Philadelphia, PAPHASE2200 participantsCrinetics Pharmaceuticals Inc.
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NCT07159308Recruiting

Motivation for Daily Living Skills

The goal of this clinical trial is to enhance motivation to complete daily living skills among 16 to 25-year-old autistic teens and young adults. Here are the main questions the trial aims to answer: ...

Philadelphia, PANA180 participantsChildren's Hospital of Philadelphia
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NCT07220876Recruiting

Safety and Effectiveness of the VisiPlate Aqueous Shunt in Patients With Refractory Open-Angle Glaucoma

A Prospective, Multicenter, Single-Arm, Open-Label Clinical Trial...

Philadelphia, PANA165 participantsAvisi Technologies Inc.
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NCT02753777Recruiting

Autoimmune Blistering Diseases Study

Pemphigus and bullous pemphigoid (BP) are severe autoimmune blistering diseases (AIBD) that pose a critical need for new therapeutic approaches. Clinical trials in pemphigus and BP will require the av...

Philadelphia, PA150 participantsUniversity of Pennsylvania
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NCT06055439Recruiting

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

The goal of this clinical trial is to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least ...

Philadelphia, PAPHASE1135 participantsChimeric Therapeutics
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NCT04213547Recruiting

Sleep and Glycemic Control in Type 2 Diabetes Adolescents

The primary objective is to determine the cross-sectional relationship between sleep duration (as measured by 14 days of actigraphy) and glycemic control in an adolescent Type 2 Diabetes (T2DM) cohort...

Philadelphia, PANA90 participantsChildren's Hospital of Philadelphia
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NCT06562881Recruiting

Patient Navigation to Improve Surgical Access in Primary Hyperparathyroidism

The goal of this study is to address surgical health equity in historically marginalized participants with primary hyperparathyroidism (PHPT). The main questions that this study aims to answer are, ho...

Philadelphia, PANA76 participantsUniversity of Pennsylvania
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NCT06904508Recruiting

Brain Activity Changes After Cognitive Behavioral Therapy for Anxiety in Autistic Youth From High-Need Communities

The goal of this clinical trial is to investigate neural constructs related to anxiety symptoms in response to Facing Your Fears (FYF) treatment in autistic participants with co-occurring anxiety. Re...

Philadelphia, PANA60 participantsMontclair State University
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NCT07501663Recruiting

Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study

The objective of the proposed pilot is to test the feasibility, acceptability, and preliminary efficacy of a 16-week sequential, multiple assessment randomized trial (SMART), which includes virtual Ta...

Philadelphia, PANA60 participantsSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
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NCT04786262Recruiting

A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia....

Philadelphia, PAPHASE357 participantsVertex Pharmaceuticals Incorporated
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NCT07222982Recruiting

Social Groups for Autistic Young Adults (SDARIYA)

This is a clinical trial that will test whether a group program called SDARI (Socio-dramatic Affective Relational Intervention) can help autistic young adults between the ages of 18 and 30 feel more c...

Philadelphia, PANA54 participantsDrexel University
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NCT07608107Recruiting

In-Shoe Loadsol Force Analysis Study LC1 Fractures

To determine if surgical fixation of geriatric pelvic ring fractures improves objective gait metrics compared to non-operative management, and to correlate gait parameters with clinical outcomes inclu...

Philadelphia, PA50 participantsUniversity of Pennsylvania
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NCT07123155Recruiting

Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

The purpose of this study is to evaluate the safety, pharmacodynamics (PD), and exploratory clinical efficacy of S-606001 in adult participants with LOPD as an add-on to ERT....

Philadelphia, PAPHASE245 participantsShionogi
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NCT05587712Recruiting

Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

The primary objectives of the study are to evaluate the safety and tolerability, and pharmacokinetics (PK) of sotatercept over 24 weeks of treatment in children ≥1 to \<18 years of age with PAH World ...

Philadelphia, PAPHASE242 participantsMerck Sharp & Dohme LLC
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NCT07175038Recruiting

A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)

This study evaluates the effect of ROC-101 in adults with either Pulmonary Arterial Hypertension (PAH) or Pulmonary Hypertension Associated with Interstitial Lung Disease (ILD-PH). Each eligible parti...

Philadelphia, PAPHASE240 participantsAllRock Bio, Inc.
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NCT05705024Recruiting

Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow. We previously studied the safety of subconjunctival injection of...

Philadelphia, PAPHASE238 participantsUniversity of Illinois at Chicago
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NCT05659901Recruiting

Rocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher Disease

The purpose of the study is to prospectively assess longitudinal changes in proteolipid protein 1 (PLP1) protein, disease-related biomarkers in cerebral spinal fluid (CSF) and blood, neuroimaging para...

Philadelphia, PA32 participantsIonis Pharmaceuticals, Inc.
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NCT06880835Recruiting

Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

This investigator-initiated study will enroll about 30 adults 18 to 65 years of age with type 1 diabetes (T1D) who are using the Tandem t:slim X2 insulin pump or Tandem Mobi insulin pump with Control-...

Philadelphia, PANA30 participantsJaeb Center for Health Research
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NCT06950099Recruiting

Advanced Neuroimaging in Idiopathic Intracranial Hypertension

Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure leading to symptoms like papilledema, headache, and cognitive dysfunction. While the etiology is complex, ...

Philadelphia, PA30 participantsThomas Jefferson University
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NCT07167446Recruiting

Neuroprotective Potential of Cannabidiol (CBD) in Preventing Oxaliplatin (Ox)-Induced Neuropathy

This is a pilot, prospective, randomized study evaluating the feasibility and acceptability of incorporating hemp-derived cannabidiol (CBD) supplementation to prevent oxaliplatin-induced peripheral ne...

Philadelphia, PAEARLY_PHASE130 participantsFox Chase Cancer Center
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NCT05836259Recruiting

Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

This is a first-in-human, non-randomized, open-label study designed to evaluate the safety, tolerability, and pharmacodynamics (PD) of TN-201 in adult patients with symptomatic hypertrophic cardiomyop...

Philadelphia, PAPHASE130 participantsTenaya Therapeutics
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NCT07080385Recruiting

Pharmacokinetics, Efficacy, and Safety of Encaleret in Pediatric Participants With Autosomal Dominant Hypocalcemia Type 1 (ADH1)

The overall objective of this study is to evaluate the pharmacokinetics (PK), efficacy, and safety of encaleret in pediatric participants from birth to 17 years of age with ADH1....

Philadelphia, PAPHASE228 participantsCalcilytix Therapeutics, Inc., a BridgeBio company
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NCT06433050Recruiting

Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy

The goal of this clinical trial is to learn if sotagliflozin, a dual SGLT1 and SGLT2 inhibitor, works to treat symptomatic, nonobstructive hypertrophic cardiomyopathy (noHCM) in adult patients. It wil...

Philadelphia, PAEARLY_PHASE126 participantsUniversity of Pennsylvania
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NCT05442671Recruiting

iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

Children with pulmonary hypertension (PH) engage in less physical activity than their peers. This is a concern since adult data support exercise as a non-pharmacologic treatment for PH. Despite adult ...

Philadelphia, PANA25 participantsChildren's Hospital of Philadelphia
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NCT04796012Recruiting

VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

This trial is a multi-center, non-randomized, open-label Phase I/II study evaluating the feasibility and efficacy of vincristine, irinotecan, temozolomide, and atezolizumab in children with relapsed/r...

Philadelphia, PAPHASE123 participantsUniversity of Texas Southwestern Medical Center
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NCT07228221Recruiting

Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma

The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative t...

Philadelphia, PAPHASE420 participantsJonathon Myers
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NCT05642455Recruiting

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

Philadelphia, PAPHASE120 participantsAdaptimmune
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NCT06668493Recruiting

Low-grade UTUC Treated With Nadofaragene Firadenovec Administered to Renal Pelvis

The primary purpose of this trial is to evaluate the safety \& tolerability of Nadofaragene Firadenovec in subjects with LG-UTUC. To help with this evaluation, a safety lead-in period will be conducte...

Philadelphia, PAPHASE120 participantsFerring Pharmaceuticals
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NCT06969261Recruiting

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by...

Philadelphia, PANA20 participantsUniversity of Pennsylvania
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NCT07282847Recruiting

A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late Onset Pompe Disease (PROGRESS-GT LOPD)

This is a single-arm, open-label, dose-escalation study to evaluate the safety, tolerability and efficacy of a single intravenous infusion of AB-1009 in adult participants with late-onset Pompe diseas...

Philadelphia, PAPHASE112 participantsAskBio Inc
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NCT06832410Recruiting

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant....

Philadelphia, PAPHASE310 participantsVertex Pharmaceuticals Incorporated
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About Pulmonary Embolism Clinical Trials in Philadelphia

Pulmonary embolism (PE) is a blockage of an artery in the lungs, usually caused by blood clots that travel from the deep veins of the legs. It can be life-threatening and requires immediate medical attention. Treatment includes anticoagulants and in severe cases, thrombolytic therapy.

There are currently 45 pulmonary embolism clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 11,754 participants. Research is being sponsored by University of Pennsylvania, Jennifer Lewey, MD, MPH, Thomas Jefferson University and 29 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Pulmonary Embolism Clinical Trials in Philadelphia — FAQ

Are there pulmonary embolism clinical trials in Philadelphia?

Yes, there are 45 pulmonary embolism clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What pulmonary embolism treatments are being tested?

The 45 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for pulmonary embolism.

Data updated October 15, 2026 from ClinicalTrials.gov