56 Heart Attack Clinical Trials in Philadelphia, PA (2026)

Q: Are there heart attack clinical trials in Philadelphia?

Yes, there are 56 heart attack clinical trials currently recruiting in Philadelphia, PA.

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Q: Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Heart Attack Studies in Philadelphia

NCT06525064Recruiting

Health-E You Efficacy Trial for Male Adolescents

This study will involve evaluating Health-E You/Salud ìTu™, a web-based, pre-visit mobile app designed to support adolescent male youth and his clinicians in discussing sexual and reproductive health ...

Philadelphia, PANA2,752 participantsJohns Hopkins University

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NCT06370520Recruiting

Screening Emotions in Adolescents at the Hospital for mTBI

The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an incr...

Philadelphia, PA2,592 participantsUniversity of California, Davis

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NCT05250375Recruiting

Natural History Study of Mitochondrial Myopathy

The goal of this observational study is to develop and validate tools to measure disease course in patients with primary mitochondrial myopathy (PMM). The main aims of this study are: * Development, ...

Philadelphia, PA1,300 participantsChildren's Hospital of Philadelphia

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NCT06080698Recruiting

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy f...

Philadelphia, PANA1,030 participantsJohns Hopkins University

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NCT04815005Recruiting

HoFH, the International Clinical Collaborators Registry

Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low-density lipo...

Philadelphia, PA1,000 participantsUniversity of Pennsylvania

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NCT04064060Recruiting

A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

A Phase 3b, open-label, single-arm, rollover study to evaluate the long-term safety of luspatercept, to the following participants: * Participants receiving luspatercept on a parent protocol at the t...

Philadelphia, PAPHASE3665 participantsCelgene

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NCT02323581Recruiting

Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts

Prospective, nonrandomized, single-center, two-arm study to assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aor...

Philadelphia, PANA520 participantsDarren Schneider, M.D.

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NCT06772493Recruiting

ViewFlex X ICE First-in-Human Study

This prospective, acute, first-in-human, non-significant risk study is intended to evaluate a modified version of the ViewFlex X ICE Catheter, Sensor Enabled (ViewFlex X SE) and ViewMate Multi Ultraso...

Philadelphia, PA500 participantsAbbott Medical Devices

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NCT05741411Recruiting

Facilitating Access to Specialty Treatment

The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel m...

Philadelphia, PANA210 participantsChildren's Hospital of Philadelphia

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NCT07220668Recruiting

Sense4Safety Intervention

Falls and fall-related injuries are significant public health issues for adults 65 years of age and older. Over a third of older adults (OA) fall each year and 10-20% of falls result in serious injuri...

Philadelphia, PAPHASE1200 participantsUniversity of Pennsylvania

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NCT06271512Recruiting

A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel

The main aim of this study is to collect real-world longitudinal data on participants with β-thalassemia treated with betibeglogene autotemcel (beti-cel) in the post marketing setting. To assess the l...

Philadelphia, PA150 participantsGenetix Biotherapeutics Inc.

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NCT07282691Recruiting

Validation of Clinical Outcome Measures Specific to mTBI-Related Oculomotor Disorders

The specific aim of this project is to validate clinical tests to be used as outcome measures in studies of mTBI-related vision problems....

Philadelphia, PA150 participantsSalus University

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NCT06055439Recruiting

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

The goal of this clinical trial is to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least ...

Philadelphia, PAPHASE1135 participantsChimeric Therapeutics

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NCT06514794Recruiting

A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)

The T-RRex study evaluates the efficacy of WU-CART-007 for patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL) and to WU-CART-007 as a ther...

Philadelphia, PAPHASE2125 participantsWugen, Inc.

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NCT06839456Recruiting

Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

The major morbidities of allogeneic hematopoietic stem cell transplant (HSCT) using donors that are not human leukocyte antigen (HLA) matched siblings are graft vs host disease (GVHD) and life- threat...

Philadelphia, PAPHASE1100 participantsChildren's Hospital of Philadelphia

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NCT07469891Recruiting

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

This is a first-in-human, open-label, multi-center Phase 1 study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of PRT12396 in participants with high-risk po...

Philadelphia, PAPHASE1100 participantsPrelude Therapeutics

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NCT06819683Recruiting

Validation of Nanosensor Oxygen Measurement

Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM). Ther...

Philadelphia, PAPHASE196 participantsChildren's Hospital of Philadelphia

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NCT05569122Recruiting

Applying pGz in Mitochondrial Disease

This is a multi-aim study, studying the effects of conventional exercise (measured through Cardiopulomary Exercises Testing or an in-bed pedal exercise) and passive exercise through periodic accelerat...

Philadelphia, PAPHASE190 participantsChildren's Hospital of Philadelphia

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NCT06655155Recruiting

A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis

The main purpose of this study is to evaluate the effect and safety of efgartigimod PH20 SC compared to placebo in adults with systemic sclerosis. The study consists of a screening period, a treatment...

Philadelphia, PAPHASE281 participantsargenx

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NCT04959474Recruiting

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

This phase II trial studies the effect of calorie reduction while undergoing stereotactic ablative radiation therapy in treating patients with breast cancer. Stereotactic ablative radiation therapy (s...

Philadelphia, PANA80 participantsThomas Jefferson University

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NCT07201922Recruiting

A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

This study is open to people aged 40 years or older who have at least 1 family member with pulmonary fibrosis. Pulmonary fibrosis is a condition where lung tissue becomes scarred, making it harder to ...

Philadelphia, PAPHASE380 participantsBoehringer Ingelheim

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NCT05932680Recruiting

Limited-duration Teclistamab

This is a single-arm, non-inferiority study in which patients who have achieved a very good partial response (VGPR) or better, according to International Myeloma Working Group (IMWG) response criteria...

Philadelphia, PAPHASE275 participantsAbramson Cancer Center at Penn Medicine

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NCT04897334Recruiting

Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve c...

Philadelphia, PANA70 participantsUniversity of Pennsylvania

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NCT06496243Recruiting

Impact of Obicetrapib and Obicetrapib Plus Repatha on Lp(a) Levels

The goal of this open label 16 week trial is to evaluate Lp(a) levels for patients with elevated Lp(a) being treated with obicetrapib and obiceptrapib/evolocumab Patients will: Have baseline Lp(a) t...

Philadelphia, PAPHASE269 participantsNewAmsterdam Pharma

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NCT05769621Recruiting

A Retrospective Study to Characterize Participants With Propionic Acidemia

This is a non-interventional, observational, global, multicenter, study describing participant characteristics, clinical outcomes, and event rates in participants with propionic acidemia (PA)....

Philadelphia, PA60 participantsModernaTX, Inc.

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NCT05140148Recruiting

Promoting Recovery After STroke With Amantadine

The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrha...

Philadelphia, PAPHASE260 participantsUniversity of Pennsylvania

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NCT03301038Recruiting

Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria

This study evaluates the efficacy of rifampin in the treatment of hypercalcemia and/or hypercalciuria in participants with at least one inactivating mutation of the CYP24A1 gene. Eligible subjects wil...

Philadelphia, PAPHASE260 participantsChildren's Hospital of Philadelphia

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NCT06651970Recruiting

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

This will be a global Phase IV, open-label, randomised study to evaluate the safety and tolerability of acalabrutinib (monotherapy, 100 mg orally \[po\], twice daily \[bd\]) compared to investigator's...

Philadelphia, PAPHASE460 participantsAstraZeneca

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NCT05327608Recruiting

Neoadjuvant Breast Cancer Time Restricted Eating

A phase II study to evaluate an innovative approach of following time restricted eating (TRE) in patients with HER2- negative breast cancer who will start neoadjuvant chemotherapy (NCT) for a new diag...

Philadelphia, PANA55 participantsThomas Jefferson University

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NCT05442216Recruiting

Tagraxofusp and Azaxitadine With or Without Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

A treatment cycle is 28 days for Cycle 1 and Cycle 2. Tagraxofusp will be administered at 12 mcg/kg IV over 15 minutes (-5 or +15 minutes) daily for 5 consecutive days (or 5 doses over a period not to...

Philadelphia, PAPHASE253 participantsJoshua Zeidner

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NCT04150497Recruiting

Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)

This is a first-in-human, open-label, dose escalation and expansion study of UCART22 administered intravenously to patients with relapsed or refractory B-cell acute Lymphoblastic Leukemia (B-ALL). The...

Philadelphia, PAPHASE152 participantsCellectis S.A.

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NCT03004326Recruiting

Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis....

Philadelphia, PA50 participantsPeter Merkel

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NCT07012044Recruiting

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

This phase I trial tests the safety, side effects, and best dose of ASTX727 and filgrastim for the treatment of children with high risk acute myeloid leukemia that has come back after a period of impr...

Philadelphia, PAPHASE147 participantsNational Cancer Institute (NCI)

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NCT07277816Recruiting

Photo-experiencing and Reflective Listening (PEARL) to Promote Healing Engagement for Survivors of Violence

The goal of this clinical trial is to learn if a photo-elicitation intervention called PEARL (Photo-experiencing and Reflective Listening) can promote healing engagement in survivors of interpersonal ...

Philadelphia, PANA40 participantsTemple University

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NCT05437705Recruiting

Decoding and Modulating Affective Brain States

The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation ...

Philadelphia, PANA40 participantsUniversity of Pennsylvania

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NCT06760546Recruiting

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

This is a sub-study of Study RM-493-040 (NCT05774756). The goal of this sub-study is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years...

Philadelphia, PAPHASE339 participantsRhythm Pharmaceuticals, Inc.

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NCT05705024Recruiting

Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow. We previously studied the safety of subconjunctival injection of...

Philadelphia, PAPHASE238 participantsUniversity of Illinois at Chicago

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NCT06430788Recruiting

A Study of Emapalumab for Pediatric Aplastic Anemia

The purpose of this study is to find out whether upfront emapalumab treatment can help in sAA (Aplastic Anemia) treatment planning and increase the effectiveness of standard treatment options. Fundin...

Philadelphia, PAPHASE235 participantsMemorial Sloan Kettering Cancer Center

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NCT04925479Recruiting

Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

The aim of this study is to support development of asciminib in the pediatric population (1 to \<18 years) previously treated with one or more TKIs. Full extrapolation of the efficacy of asciminib fro...

Philadelphia, PAPHASE134 participantsNovartis Pharmaceuticals

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NCT06934382Recruiting

Anti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma

This will be a Phase 1, open-label study to evaluate the safety and efficacy of BEAM-201 in patients with R/R T-ALL or T-LLy. BEAM-201 is an allogeneic anti-CD7 CART therapy....

Philadelphia, PAPHASE133 participantsStephan Grupp MD PhD

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NCT05766839Recruiting

Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

A study to evaluate the pharmacodynamic effects, safety, and tolerability of patiromer in children under 12 years of age with hyperkalaemia...

Philadelphia, PAPHASE232 participantsVifor Pharma, Inc.

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NCT07548099Recruiting

Molecular Imaging of the Underlying Mechanism of Vessel Wall Inflammation Using Positron Emission Tomography (PET/CT)

This research study is being conducted to test how an imaging drug called 64Cu-DOTA-ECL1i can be used to image an abdominal aortic aneurysm. 64Cu-DOTA-ECL1i is a drug used with an imaging test called ...

Philadelphia, PA30 participantsUniversity of Pennsylvania

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NCT07464951Recruiting

CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia

This study is designed to evaluate the safety and effectiveness of CART123 cells either alone or when combined with ruxolitinib in pediatric and young adult subjects with relapsed or refractory AML. S...

Philadelphia, PAPHASE130 participantsStephan Grupp MD PhD

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NCT04029337Recruiting

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

Study to evaluate the feasibility, safety and performance of the HighLife trans-septal Transcatheter Mitral Valve in patients with moderate-severe and severe mitral regurgitation who are at high risk ...

Philadelphia, PANA30 participantsHighLife SAS

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NCT07080385Recruiting

Pharmacokinetics, Efficacy, and Safety of Encaleret in Pediatric Participants With Autosomal Dominant Hypocalcemia Type 1 (ADH1)

The overall objective of this study is to evaluate the pharmacokinetics (PK), efficacy, and safety of encaleret in pediatric participants from birth to 17 years of age with ADH1....

Philadelphia, PAPHASE228 participantsCalcilytix Therapeutics, Inc., a BridgeBio company

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NCT06299891Recruiting

Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity

Hypothalamic obesity (HO) refers to the substantial weight gain that often complicates hypothalamic brain tumors. Children with this treatment-recalcitrant form of obesity have excess rates of metabol...

Philadelphia, PAPHASE224 participantsSeattle Children's Hospital

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NCT05627232Recruiting

Tazemetostat and Palbociclib With CPX-351for R/R AML

This is a two-part phase Ib dose escalation study to evaluate the safety and preliminary efficacy of the combination of tazemetostat and CPX-351 (Part 1) and of pre-treatment with palbociclib followed...

Philadelphia, PAPHASE124 participantsThomas Jefferson University

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NCT06177067Recruiting

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

This is a research study to find out if adding a new study drug called revumenib to commonly used chemotherapy drugs is safe and if they have beneficial effects in treating patients with acute myeloid...

Philadelphia, PAPHASE124 participantsSt. Jude Children's Research Hospital

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NCT04990102Recruiting

Phase IB/II of CPX-351 for Relapse Prevention in AML

This is a phase IB/II study with a 3+3 dose de-escalation study design. Patients will continue maintenance treatment with CPX-351 for 6 cycles on D1 and D3, as long as patient remains in CR. The dose ...

Philadelphia, PAPHASE124 participantsGeorgetown University

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NCT04086329Recruiting

Validation of Oxygen Nanosensor in Mitochondrial Myopathy

Philadelphia, PAPHASE124 participantsChildren's Hospital of Philadelphia

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NCT05642455Recruiting

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

Philadelphia, PAPHASE120 participantsAdaptimmune

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NCT06376162Recruiting

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

The primary objective of the study is to determine the recommended phase 2 dose (RP2D) of ziftomenib in combination with chemotherapy (FLA) in children with relapsed or refractory KMT2A-r, NUP98-r, or...

Philadelphia, PAPHASE120 participantsPedAL BCU, LLC

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NCT05029336Recruiting

Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases

A subset of autoimmune diseases (ADs) in children and young adults are life-threatening and unresponsive to conventional treatments. In these patients, the delivery of high dose immunosuppressive ther...

Philadelphia, PAPHASE220 participantsStephan Grupp MD PhD

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NCT07148089Recruiting

A Study of SGT-501 Gene Therapy in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

This is a Phase 1b, Multicenter, Open-Label, Dose Finding Study to Investigate the Safety and Tolerability of a Single Intravenous Dose of SGT-501 in participants with catecholaminergic polymorphic ve...

Philadelphia, PAPHASE118 participantsSolid Biosciences Inc.

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NCT05945849Recruiting

CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

The purpose of this study is to provide a new type of treatment for AML. This treatment combines a new type of stem cell transplant along with treatment using chimeric antigen receptor (CAR) T cells t...

Philadelphia, PAPHASE116 participantsUniversity of Pennsylvania

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NCT06364774Recruiting

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

The main goal of this study is to find out if the blood disorder called transfusion-dependent beta thalassemia can be safely treated by modifying blood stem cells. This is done by collecting blood ste...

Philadelphia, PAPHASE112 participantsChildren's Hospital of Philadelphia

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About Heart Attack Clinical Trials in Philadelphia

A heart attack (myocardial infarction) occurs when blood flow to part of the heart muscle is blocked, usually by a blood clot. It is a medical emergency requiring immediate treatment. Long-term management includes medications, lifestyle changes, and cardiac rehabilitation.

There are currently 56 heart attack clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 13,302 participants. Research is being sponsored by Johns Hopkins University, University of California, Davis, Children's Hospital of Philadelphia and 35 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Attack Clinical Trials in Philadelphia — FAQ

Are there heart attack clinical trials in Philadelphia?

Yes, there are 56 heart attack clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What heart attack treatments are being tested?

The 56 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for heart attack.

Data updated July 16, 2026 from ClinicalTrials.gov