8 Stroke Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Stroke Studies in Philadelphia

NCT06530693Recruiting

Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)

This interventional trial will compare a novel prehospital stroke transport algorithm (OPUS-i) to a traditional prehospital stroke transport algorithm to improve outcomes in rural stroke patients by d...

Philadelphia, PANA360 participantsTemple University

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NCT05701280Recruiting

Pilot/Pivotal Study of DBS+Rehab After Stroke

The RESTORE Stroke Study will evaluate the safety and effectiveness of DBS+Rehab for treating arm weakness and reduced function after a stroke....

Philadelphia, PANA202 participantsEnspire DBS Therapy, Inc.

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NCT06092814Recruiting

tACS to Enhance Language Abilities

The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and...

Philadelphia, PANA120 participantsUniversity of Pennsylvania

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NCT04897334Recruiting

Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve c...

Philadelphia, PANA70 participantsUniversity of Pennsylvania

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NCT06968663Recruiting

Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when...

Philadelphia, PAPHASE263 participantsUniversity of Pennsylvania

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NCT05140148Recruiting

Promoting Recovery After STroke With Amantadine

The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrha...

Philadelphia, PAPHASE260 participantsUniversity of Pennsylvania

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NCT06368193Recruiting

The Neuralert Stroke Monitor Pilot Trial

This trial aims to demonstrate that the Neuralert Monitoring System will detect strokes before they would be identified by current standard of care. Each patient will be monitored for up to five days,...

Philadelphia, PANA50 participantsNeuralert Technologies LLC

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NCT06904911Recruiting

Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy

This is a prospective, single-arm, open-label study to evaluate the efficacy of intra-arterial tenecteplase in improving microvascular reperfusion following successful large vessel recanalization. Acu...

Philadelphia, PAPHASE220 participantsUniversity of Pennsylvania

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About Stroke Clinical Trials in Philadelphia

A stroke occurs when blood flow to part of the brain is interrupted or reduced, depriving brain tissue of oxygen and nutrients. It is a leading cause of disability and death. Rapid treatment is critical, and prevention focuses on managing risk factors like hypertension and atrial fibrillation.

There are currently 8 stroke clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 945 participants. Research is being sponsored by Temple University, Enspire DBS Therapy, Inc., University of Pennsylvania and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Stroke Clinical Trials in Philadelphia — FAQ

Are there stroke clinical trials in Philadelphia?

Yes, there are 8 stroke clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What stroke treatments are being tested?

The 8 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for stroke.

Data updated July 17, 2026 from ClinicalTrials.gov