NCT06832878 · Mayo Clinic
Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty
What this study is about
The purpose of this study is to evaluate the impact of an extended taken by mouth Tranexamic Acid regimen on patient reported outcome scores, time to independent ambulation, postoperative range of motion, swelling, change in hemoglobin levels, 90-day complications, readmission and reoperation.
View original scientific description
The purpose of this study is to evaluate the impact of an extended oral Tranexamic Acid regimen on patient reported outcome scores, time to independent ambulation, postoperative range of motion, swelling, change in hemoglobin levels, 90-day complications, readmission and reoperation.
Interventions
DRUG
Oral Tranexamic Acid
Subjects will receive a 1.95 g dose of oral TXA at the following timepoints: (1) following ambulation, (2) postoperative day 1, (3) postoperative day 2, and (4) postoperative day 3
Primary outcome measures
Visual Analog Score
Time frame: Baseline, 3 days postoperative, 2 weeks, 6 weeks, 12 weeks
The VAS is a 11-item questionnaire assessing pain. Using a scale of 0 = no pain to 10 = worst pain. Total scores range from 0 - 110, lower scores indicating lower pain and higher scores indicating greater pain.
Hip Disability and Osteoarthritis Outcome Score (HOOS) for Joint Replacement (JR)
Time frame: Baseline, 3 days postoperative, 2 weeks, 6 weeks, 12 weeks
The Hip Disability and Osteoarthritis Outcome Score (HOOS) for Joint Replacement (JR) is a questionnaire designed to measure outcomes for patients with hip replacements. Results are scored 0-11. 0 = total hip disability, 100 = perfect hip health.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adults aged \> 18 years (All women of childbearing potential undergo pregnancy testing prior to THA as per our institutional protocol)
- Written informed consent
- Patients undergoing primary THA diagnosis of end-stage osteoarthritis
- Patients receiving spinal anesthesia
- Patients being discharged on postoperative day 1
Exclusion criteria
- Patients with a TXA allergy
- Patients undergoing revision procedures
- Patients undergoing primary THA for a diagnosis other than end-stage osteoarthritis
- Patients receiving general anesthesia
- Patients being discharged on the same day of surgery
- Cancer patients
- Patients with a history of prior VTE event
- Patients on preoperative anticoagulants other than ASA
- Pregnant patients (All women of child bearing potential undergo pregnancy testing prior to THA as per our institutional protocol)
- Female patients who are on hormonal contraception
- Patients with history of retinal vein or artery occlusion
Where
- Scottsdale, Arizona
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 10, 2026 · Source of record for eligibility and locations