Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Knee Replacement Clinical Trials
Knee Replacement clinical trials are recruiting across 34 cities. Here are the cities with the most active studies:
Knee Replacement Trial Phases
22 research organizations are sponsoring knee replacement trials.
About Knee Replacement
Knee replacement surgery replaces weight-bearing surfaces of the knee joint with metal and plastic components to relieve pain and restore function. It is typically performed for severe osteoarthritis. Clinical trials investigate improved implant designs, surgical techniques, and pain management protocols.
Clinical trials are advancing new treatments for knee replacement. Currently, 26 studies are recruiting a combined 209,072 participants across the United States. Research is being conducted by 22 organizations including HealthEast Care System, University of Colorado, Denver, Regeneron Pharmaceuticals and 19 others.
2026 Knee Replacement Research Landscape
As of July 2026, the knee replacement clinical trial landscape includes 26 actively recruiting studies across 34 cities in the United States. These studies are collectively seeking 209,072 participants, with an average enrollment target of 8,041 per study.
The research spans multiple phases of development: 14 studies are in NA, 4 studies are in PHASE4, 3 studies are in PHASE1, 2 studies are in PHASE3, 2 studies are in PHASE2. The presence of Phase 3 trials indicates that some knee replacement treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 22 different organizations, including HealthEast Care System, University of Colorado, Denver, Regeneron Pharmaceuticals, Limacorporate S.p.a, Rush University Medical Center, and 17 others. The large number of sponsors reflects significant research interest and investment in knee replacement treatment advancement.
Geographically, knee replacement trials are most concentrated in New York, New York (4 trials); Aurora, Colorado (3 trials); Miami, Florida (3 trials); Chicago, Illinois (2 trials); Saint Paul, Minnesota (1 trial) and 7 other cities.
Featured Knee Replacement Studies
Highlighted recruiting studies for knee replacement, selected by enrollment size and research scope.
HealthEast Community Hip and Knee Replacement Registry
HealthEast Care System began the first community-based joint replacement registry (HJRR) in the U.S. in 1991, and now has more than 30,000 total joints registered. The purpose of the HJRR is to maintain and improve the care of individuals undergoing joint replacement surgery by providing timely information to their surgeons and the broader orthopaedic community. As it moves into the third decade,...
Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty
Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation (NMES) reduces quadriceps weakness and improves patient function after knee replacement, but it is drastically underused in rehabilitation practice. This randomized trial will examine the effe...
REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing venous thromboembolism (VTE) and other related diseases after total knee replacement surgery. The study is looking at several oth...
Frequently Asked Questions About Knee Replacement Clinical Trials
Are there knee replacement clinical trials near me?
Yes, there are 26 knee replacement clinical trials currently recruiting across 34+ cities in the United States, including New York, New York; Aurora, Colorado; Miami, Florida. Browse the studies above to find one at a location convenient for you.
How do I join a knee replacement clinical trial?
To join a knee replacement clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are knee replacement clinical trials free?
Yes, participation in knee replacement clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of knee replacement treatments are being studied?
Current knee replacement clinical trials are testing a range of approaches across NA (14 studies), PHASE4 (4 studies), PHASE1 (3 studies), PHASE3 (2 studies), PHASE2 (2 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 22 research organizations.
Is it safe to participate in knee replacement clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 18, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 18, 2026 · Data from ClinicalTrials.gov