84 Active Studies

Fibromyalgia Clinical Trials

Find actively recruiting research studies for fibromyalgia. Connect with study sites near you and explore new treatment options.

84
Active Trials
203+
Locations
28,673
Participants Needed

Recruiting Studies

RecruitingNCT07037459

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

This study will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascu...

10 locations(Dothan, Fairhope, Huntsville)
5,056 participants
Amgen
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RecruitingNCT06632444

LIVERAGEā„¢: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

This study is open to adults who are at least 18 years old living with obesity and have: * a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (...

10 locations(Peoria, Scottsdale, Tucson)
1,800 participants
Boehringer Ingelheim
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RecruitingNCT06238622

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medic...

10 locations(Birmingham, Tucson, Los Angeles)
1,700 participants
Boehringer Ingelheim
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RecruitingNCT06215716

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with non-cirrhotic NASH/MASH and fibrosis stage 2 or 3 (F2 or F3). The stud...

10 locations(Birmingham, Dothan, Chandler)
1,650 participants
Akero Therapeutics, Inc
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RecruitingNCT06025578

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis....

10 locations(Birmingham, Phoenix, Phoenix)
1,092 participants
Bristol-Myers Squibb
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RecruitingNCT06318169

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

The study will assess the efficacy and safety of 2 dose regimens of pegozafermin for the treatment of liver fibrosis stage 2 or 3 in adult participants with MASH (previously known as nonalcoholic stea...

10 locations(Birmingham, Chandler, Flagstaff)
1,050 participants
89bio, Inc.
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RecruitingNCT05862272

A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatm...

10 locations(Mobile, Chandler, Mesa)
1,000 participants
Sumitomo Pharma Switzerland GmbH
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RecruitingNCT04849728

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )

This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3...

10 locations(Anniston, Birmingham, Dothan)
1,000 participants
Inventiva Pharma
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RecruitingNCT06419374

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

The study will assess the efficacy and safety of pegozafermin administered in participants with compensated cirrhosis due to MASH (biopsy-confirmed fibrosis stage F4 MASH \[previously known as nonalco...

10 locations(Homewood, Chandler, Flagstaff)
762 participants
89bio, Inc.
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RecruitingNCT05548283

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or I...

10 locations(Birmingham, Tucson, La Jolla)
730 participants
Chris Goss
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RecruitingNCT06578247

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (I...

10 locations(Goodyear, Phoenix, Tucson)
700 participants
Daiichi Sankyo
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RecruitingNCT05943535

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period....

10 locations(Birmingham, Phoenix, Los Angeles)
698 participants
United Therapeutics
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RecruitingNCT06479135

Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-NaĆÆve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

This clinical trial is evaluating whether addition of navtemadlin to ruxolitinib treatment will provide more clinical benefit than ruxolitinib alone for patients with Myelofibrosis who have a suboptim...

10 locations(Birmingham, Gilbert, Phoenix)
600 participants
Kartos Therapeutics, Inc.
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RecruitingNCT02559778

Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

A prospective open label, multicenter study to evaluate the feasibility and acute toxicity of using molecularly guided therapy in combination with standard therapy followed by a Randomized Controlled ...

10 locations(Birmingham, Little Rock, Oakland)
500 participants
Giselle Sholler
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RecruitingNCT02679144

Neuroblastoma Maintenance Therapy Trial

Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluo...

10 locations(Birmingham, Little Rock, Oakland)
441 participants
Giselle Sholler
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RecruitingNCT06151197

Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)

This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease)....

10 locations(Mesa, Scottsdale, Tucson)
418 participants
Endo Pharmaceuticals
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RecruitingNCT06244771

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

The goal of this clinical trial is to evaluate FMC-376 in participants with advanced solid tumors with KRAS G12C mutations. This clinical trial will be conducted in 3 parts: Phase 1A (Dose Escalation)...

10 locations(La Jolla, Orange, San Francisco)
403 participants
Frontier Medicines Corporation
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RecruitingNCT05566795

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in ...

10 locations(Birmingham, Phoenix, Los Angeles)
400 participants
Day One Biopharmaceuticals, Inc.
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RecruitingNCT06806592

A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

Adults 18 years of age and older or above legal age with lung fibrosis related to systemic autoimmune rheumatic disease can participate in this study. People can only take part if they show no improve...

10 locations(Birmingham, Scottsdale, Los Angeles)
400 participants
Boehringer Ingelheim
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RecruitingNCT03165734

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia ...

10 locations(Birmingham, Phoenix, Duarte)
399 participants
Swedish Orphan Biovitrum
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RecruitingNCT03662126

KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition...

10 locations(Birmingham, Los Angeles, Stanford)
385 participants
Kartos Therapeutics, Inc.
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RecruitingNCT04278768

Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)

This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Sy...

10 locations(Tampa, Atlanta, Chicago)
366 participants
Curis, Inc.
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RecruitingNCT04562389

Study of Selinexor in Combination with Ruxolitinib in Myelofibrosis

This is a global, multicenter, 2-part study to evaluate the efficacy and safety of selinexor plus ruxolitinib in JAK inhibitor (JAKi) treatment-naĆÆve myelofibrosis (MF) participants. The study will be...

10 locations(Birmingham, Beverly Hills, Duarte)
350 participants
Karyopharm Therapeutics Inc
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RecruitingNCT04041479

Biomarker-guided rTMS for Treatment Resistant Depression

Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research ...

2 locations(Stanford, New York)
348 participants
Weill Medical College of Cornell University
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RecruitingNCT04576156

A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

The purpose of the study is to evaluate the overall survival of participants treated with imetelstat compared to best available therapy with intermediate-2 or high-risk Myelofibrosis (MF) who are rela...

10 locations(La Jolla, Long Beach, Los Alamitos)
320 participants
Geron Corporation
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RecruitingNCT05785624

A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease

The main purpose of the study is to evaluate the efficacy of vixarelimab compared with placebo on lung function in participants with idiopathic pulmonary fibrosis (IPF) and in participants with system...

10 locations(Birmingham, Phoenix, Tucson)
320 participants
Genentech, Inc.
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RecruitingNCT06329401

A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants wit...

10 locations(Birmingham, Phoenix, Los Angeles)
300 participants
Avalyn Pharma Inc.
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RecruitingNCT06588686

A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.

The ASPIRE trial is a 52 week randomized, double-blind, placebo-controlled, parallel-group, multicenter trial in which the efficacy, safety, and pharmacokinetics of orally administered buloxibutid, ei...

10 locations(Birmingham, Los Angeles, Redding)
270 participants
Vicore Pharma AB
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RecruitingNCT04176198

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

This study is a Phase 1/2, multicenter, dose-escalation, open-label trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of nuvisertib (TP-3654) in patients with intermediate or...

10 locations(Birmingham, Tucson, Duarte)
240 participants
Sumitomo Pharma America, Inc.
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RecruitingNCT04939610

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

Fibroblast activation protein (FAP) is a cell surface protein that is highly expressed on the surface of cancer-associated fibroblasts (CAFs) present in the tumor microenvironment of most epithelial c...

10 locations(Birmingham, Irvine, Los Angeles)
222 participants
Novartis Pharmaceuticals
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RecruitingNCT04166409

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated lo...

10 locations(Birmingham, Mesa, Phoenix)
220 participants
National Cancer Institute (NCI)
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RecruitingNCT05422222

Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combina...

10 locations(Orange, Palo Alto, Aurora)
210 participants
Vertex Pharmaceuticals Incorporated
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RecruitingNCT06188741

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

Plexiform neurofibromas (PN) are known to cause significant morbidity in children with NF1. The recent FDA approval for selumetinib in children 2 years and older with inoperable symptomatic PN was bas...

3 locations(Birmingham, Cincinnati, Philadelphia)
200 participants
University of Alabama at Birmingham
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RecruitingNCT05948475

Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

This study is a Phase III, Randomized, Controlled, Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib versus Physician's Choice in Subjects with Fibroblast Growth Factor...

10 locations(Santa Monica, Stanford, Westwood, Los Angeles)
200 participants
TransThera Sciences (Nanjing), Inc.
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RecruitingNCT06559150

A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

This study is a randomized, double-blind, placebo-controlled study designed to assess the efficacy and safety of ensifentrine inhalation suspension (3 mg) delivered twice daily via standard jet nebuli...

10 locations(Birmingham, Los Angeles, Sacramento)
180 participants
Verona Pharma plc
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RecruitingNCT06967805

WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

A Phase 2a, Randomized, Double-blind, Placebo-Controlled Study of the Safety and Efficacy of MTX-463 in Participants with Idiopathic Pulmonary Fibrosis (IPF)...

8 locations(Phoenix, Newport Beach, Palm Springs)
164 participants
Mediar Therapeutics
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RecruitingNCT05677971

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

The main aim of this study is to learn if fazirsiran reduces liver scarring (fibrosis) compared to placebo. Other aims are to learn if fazirsiran slows down the disease worsening in the liver, to get ...

10 locations(Birmingham, Phoenix, Phoenix)
160 participants
Takeda
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RecruitingNCT06449677

Bionic Pancreas in CFRD

This multi-center randomized controlled trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System (BP) versus a control group using...

10 locations(Aurora, New Haven, Atlanta)
150 participants
Jaeb Center for Health Research
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RecruitingNCT05320198

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

This phase 1b/2a open-label study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of DISC-0974 as well as categorize the effects on anemia response in subjects with myelofi...

10 locations(Jacksonville, Ann Arbor, Rochester)
150 participants
Disc Medicine, Inc
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RecruitingNCT04301843

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma....

10 locations(Birmingham, Little Rock, Oakland)
131 participants
Giselle Sholler
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RecruitingNCT06824168

Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission

This clinical two-arm trial is designed to evaluate two doses of quizartinib as maintenance therapy after induction/consolidation in participants with FMS-like tyrosine kinase 3 (FLT3)-internal tandem...

10 locations(Baltimore, Worcester, Buffalo)
130 participants
Daiichi Sankyo
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RecruitingNCT05571059

Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Ifetroban prevents and treats lung fibrosis due to multiple causes (bleomycin, genetic, radiation). The safety and efficacy of oral ifetroban will be assessed in patients with IPF....

10 locations(San Francisco, Jacksonville, Miami)
128 participants
Cumberland Pharmaceuticals
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RecruitingNCT04655118

Study of TL-895 in Subjects With Myelofibrosis or Indolent Systemic Mastocytosis

This study evaluates TL-895, a potent, orally-available and highly selective irreversible tyrosine kinase inhibitor for the treatment of Myelofibrosis (Cohorts 1-3) or Indolent Systemic Mastocytosis (...

10 locations(Aurora, Rochester, Canton)
121 participants
Telios Pharma, Inc.
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RecruitingNCT06374875

Fibrosis Lessens After Metabolic Surgery

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity...

10 locations(Phoenix, Indianapolis, Rochester)
120 participants
Ali Aminian
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RecruitingNCT04821141

Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens

Women at risk for development of breast cancer and experiencing vasomotor menopausal symptoms (hot flashes) will be randomized to bazedoxifene (BZA) plus conjugated estrogens (CE) for 6 months versus ...

5 locations(Duarte, San Francisco, Chicago)
120 participants
University of Kansas Medical Center
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RecruitingNCT04696029

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma....

10 locations(Little Rock, Oakland, San Diego)
118 participants
Giselle Sholler
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RecruitingNCT05980806

A Study of Selinexor Monotherapy in Subjects with JAK Inhibitor-naĆÆve Myelofibrosis and Moderate Thrombocytopenia

The main purpose of this study with corresponding optional expansion is to evaluate the efficacy of selinexor in JAKi-naĆÆve participants with myelofibrosis (MF) and moderate thrombocytopenia based on ...

10 locations(Duarte, Columbia, New York)
118 participants
Karyopharm Therapeutics Inc
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RecruitingNCT03420014

Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA)

The present study is an open-label, randomized, controlled, two-arm multi-center study of the efficacy of L19TNF treatment in combination with doxorubicin versus doxorubicin alone in metastatic leiomy...

8 locations(Phoenix, Santa Monica, Jacksonville)
114 participants
Philogen S.p.A.
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RecruitingNCT06269146

Pramipexole to Enhance Social Connections

This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 pa...

2 locations(San Diego, New York)
108 participants
University of California, San Diego
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RecruitingNCT05389215

Clinical Trial to Evaluate the Safety and Efficacy of DWN12088 in Patients With IPF

This is a randomized, double-blinded, placebo-controlled multicenter study to evaluate the safety and efficacy of DWN12088 in patients with Idiopathic Pulmonary Fibrosis....

10 locations(Mesa, Phoenix, San Francisco)
102 participants
Daewoong Pharmaceutical Co. LTD.
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RecruitingNCT07002034

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adj...

10 locations(Birmingham, San Diego, Santa Rosa)
100 participants
Reunion Neuroscience Inc
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RecruitingNCT05090891

To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva

This Phase 2, Randomized, Double-Blind, Placebo-Controlled Study is intended to evaluate the Efficacy, Safety, and Tolerability and PK of INCB000928 administered to participants with a clinical diagno...

10 locations(San Francisco, Rochester, Philadelphia)
98 participants
Incyte Corporation
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RecruitingNCT07148739

Ensuring Access to Optimal Therapy in CF: The ENACT Study

This clinical trial is examining the action and effects of several new drugs in the treatment of cystic fibrosis in children. In addition, several genetic factors are examined. The hope is that the ab...

2 locations(Little Rock, Seattle)
95 participants
Arkansas Children's Hospital Research Institute
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RecruitingNCT05130866

Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas

This is a two-staged, Phase 2/3, randomized, multi-center study to investigate the efficacy and safety of REC-2282 in patients with progressive NF2 mutated meningiomas....

10 locations(Los Angeles, Los Angeles, Washington D.C.)
92 participants
Recursion Pharmaceuticals Inc.
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RecruitingNCT06508021

A Study of Andecaliximab in Participants With Fibrodysplasia Ossificans Progressiva (FOP)

This study is researching an experimental drug called andecaliximab. The study will include pediatric and adult patients with fibrodysplasia ossificans progressiva (FOP). The study will evaluate how s...

3 locations(San Francisco, Rochester, Philadelphia)
92 participants
Ashibio Inc
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RecruitingNCT05519475

A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have metabolic dysfunction-associated steatohepatitis (MASH). MAS...

10 locations(Chandler, Flagstaff, Peoria)
90 participants
Regeneron Pharmaceuticals
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RecruitingNCT06620302

Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

This phase I/II trial tests the safety, side effects and best dose of DT2216 in combination with irinotecan and how well it works in treating children, adolescents and young adults with solid tumors a...

10 locations(Birmingham, Los Angeles, Orange)
81 participants
Children's Oncology Group
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RecruitingNCT04641702

Comprehensive Esophageal Diagnostics Study

The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that ut...

2 locations(Atlanta, Atlanta)
80 participants
Emory University
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RecruitingNCT06465186

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic s...

10 locations(Chandler, Flagstaff, Peoria)
80 participants
Merck Sharp & Dohme LLC
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RecruitingNCT06016088

A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

A double-blind, active-controlled, multiple-ascending dose, safety study of aerosolized RSP-1502 in subjects with cystic fibrosis Pseudomonas aeruginosa lung infection....

10 locations(Tucson, Los Angeles, Palo Alto)
72 participants
Respirion Pharmaceuticals Pty Ltd
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RecruitingNCT05280509

Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-NaĆÆve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib

This study evaluates TL-895, a potent, orally-available and highly selective irreversible tyrosine kinase inhibitor for the treatment of Myelofibrosis. Participants must have MF (PMF, Post PV MF, or P...

10 locations(Birmingham, Canton, Cincinnati)
70 participants
Telios Pharma, Inc.
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RecruitingNCT05594563

TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

The goal of this clinical trial is to test a drug known as DFMO in people with Type 1 Diabetes (T1D). The main question\[s\] it aims to answer are: * Does it reduce stress on the cells that make insu...

7 locations(Aurora, Chicago, Indianapolis)
70 participants
Emily K. Sims
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RecruitingNCT05028829

Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk

Prospective randomized, multi-center, double blind placebo-controlled trial to assess the chemopreventive impact of atorvastatin (20 mg oral) vs placebo in up to 60 adults with advanced fibrosis at hi...

2 locations(Boston, Dallas)
60 participants
Raymond Chung
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RecruitingNCT05975983

Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis

The goal of this clinical trial is to learn about INS018\_055 in adults with Idiopathic Pulmonary Fibrosis (IPF). The primary objective is to evaluate the safety and tolerability of INS018\_055 orall...

10 locations(Birmingham, Scottsdale, Los Angeles)
60 participants
InSilico Medicine Hong Kong Limited
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RecruitingNCT05350371

Safety and Tolerability of Pirfenidone in Acute Pancreatitis

The goal of the current pilot clinical trial is to evaluate the safety and tolerability of pirfenidone in patients with predicted moderately severe and severe acute pancreatitis. Pirfenidone is curren...

2 locations(Birmingham, Rochester)
60 participants
University of Alabama at Birmingham
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RecruitingNCT04878003

Study of KRT-232 or TL-895 in Janus Associated Kinase Inhibitor Treatment-NaĆÆve Myelofibrosis

This study evaluates either KRT-232 or TL-895 in treatment naĆÆve patients with myelofibrosis (MF) The study will be conducted in 2 stages. Stage 1 will evaluate safety, tolerability, and efficacy of ...

10 locations(Glendale, Whittier, Canton)
52 participants
Kartos Therapeutics, Inc.
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RecruitingNCT06165341

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

The liver produces a protein called alpha-1 antitrypsin (AAT). AAT is normally released into the bloodstream. In some people, the liver makes an abnormal version of the AAT protein, called Z-AAT. Maki...

10 locations(Phoenix, Phoenix, Tucson)
50 participants
Takeda
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RecruitingNCT05364008

FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea

The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women se...

4 locations(New Haven, Chicago, Chicago)
50 participants
Yale University
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RecruitingNCT03914794

A Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients With Recurrent Low- or Intermediate-Risk Tumors

This phase II trial studies how well Pemigatinib (an orally administered inhibitor of fibroblast growth factor receptors 1, 2, and 3) works in non-muscle invasive bladder cancer (NMIBC) patients with ...

6 locations(Washington D.C., Baltimore, Syracuse)
43 participants
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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RecruitingNCT06920043

A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

The purpose of this study is to evaluate the safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of efimosfermin in participants with metabolic dysfunction associated steatohepatitis...

10 locations(Chandler, Peoria, Tucson)
42 participants
Boston Pharmaceuticals
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RecruitingNCT06159725

A Study To Evaluate The Safety Of CMTX-101 In People With Cystic Fibrosis

CMTX-101 is a bacterial biofilm disrupting monoclonal antibody being developed as an adjunctive therapy to standard of care antibiotics. The goal of this clinical trial is to assess the safety and tol...

10 locations(Birmingham, Palo Alto, San Franciso)
41 participants
Clarametyx Biosciences, Inc.
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RecruitingNCT06906562

A Phase II Nationwide, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreas Cancer With FGFR Genetic Alterations

This phase II study evaluates how well pemigatinib works for the treatment of adult patients with pancreatic cancer that has spread from where it first started to nearby tissue, lymph nodes, or distan...

8 locations(Birmingham, San Francisco, Miami)
40 participants
Sameek Roychowdhury
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RecruitingNCT02675959

Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoi...

4 locations(Los Angeles, Gainesville, Valhalla)
40 participants
New York Medical College
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RecruitingNCT05248230

4D-710 in Adult Patients With Cystic Fibrosis

This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with cystic fibrosis....

10 locations(Birmingham, Tucson, San Francisco)
40 participants
4D Molecular Therapeutics
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RecruitingNCT06773195

A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

The researchers are doing this study to find out whether the combination of ruxolitinib and ulixertinib is a safe and effective treatment for people with myelofibrosis. The researchers will test diffe...

9 locations(Boston, Basking Ridge, Middletown)
37 participants
Memorial Sloan Kettering Cancer Center
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RecruitingNCT04731272

GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced β-cell mass contributes to the insulin secretory defects that char...

2 locations(Aurora, Philadelphia)
30 participants
University of Pennsylvania
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RecruitingNCT05835466

Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium (MPN-RC 120)

This is an open label, phase II study to assess the efficacy, safety, and tolerability of Reparixin in patients with DIPSS intermediate-2, or high-risk primary myelofibrosis (PMF), post essential thro...

9 locations(Tampa, Atlanta, Buffalo)
26 participants
Icahn School of Medicine at Mount Sinai
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RecruitingNCT06429176

Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients with Cystic Fibrosis

The goal of this clinical trial is to learn if drug SPL84 is safe for adult patients with cystic fibrosis (CF). It will also learn if the drug works to treat works to treat CF with a specific mutation...

2 locations(Boston, Columbus)
24 participants
SpliSense Ltd.
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RecruitingNCT06541847

A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1

The trial will be an open label, single arm, phase 2 study in 20 participants. The study will assess the tolerability and efficacy of HLX-1502 in participants with NF1 16 years of age or older with pr...

10 locations(Birmingham, Los Angeles, Washington D.C.)
20 participants
Healx Limited
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RecruitingNCT06620042

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

This is a prospective open-label observational study of patients with treatment resistant bipolar depression referred for intravenous ketamine, with an interventional component of fMRI....

2 locations(Cleveland, Ohio City)
20 participants
Brian Barnett
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RecruitingNCT06526923

A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

This is a Phase 1/2 multicenter, open-label, single dose trial of SP-101 investigational gene therapy in adults with CF who are ineligible for or intolerant to CFTR modulator therapy....

4 locations(Kansas City, Boston, New York)
15 participants
Spirovant Sciences, Inc.
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RecruitingNCT05467800

Study of Canakinumab in Patients With Myelofibrosis

This is an open label, multicenter, phase 2 trial of Canakinumab in patients with primary myelofibrosis (PMF), post essential thrombocythemia/polycythemia vera related MF (Post ET/PV MF). Eligible pat...

8 locations(Phoenix, Los Angeles, Tampa)
14 participants
John Mascarenhas
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RecruitingNCT05783323

Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer

Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioacti...

5 locations(San Francisco, Philadelphia, Memphis)
13 participants
Children's Hospital of Philadelphia
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RecruitingNCT06747858

Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis

ARCT-032-02 is a Phase 2, open-label, multicenter, multiple-ascending dose study of ARCT-032 in adults with CF who are not eligible for CFTR modulator therapy or are not taking CFTR modulators due to ...

9 locations(Little Rock, Los Angeles, Orlando)
12 participants
Arcturus Therapeutics, Inc.
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Frequently Asked Questions

What clinical trials are available for Fibromyalgia?

There are currently 84 actively recruiting clinical trials for fibromyalgia. These studies are testing new treatments, therapies, and interventions at research sites across 203 cities.

How do I join a Fibromyalgia clinical trial?

To join a fibromyalgia clinical trial: 1) Browse the available studies above, 2) Click on a study that interests you, 3) Complete the eligibility form, and 4) A study coordinator will contact you.

Are clinical trials free for patients?

Yes, clinical trial participation is free. In most studies, the treatment, medical tests, and doctor visits related to the trial are provided at no cost. Some studies may also compensate for time and travel.

Can I leave a clinical trial if I change my mind?

Yes, participation in any clinical trial is completely voluntary. You can withdraw at any time, for any reason, without affecting your regular medical care.