Galveston, TXNCT05331170Now EnrollingIRB Ready

Asthma Clinical Trial in Galveston, TX

Access cutting-edge asthma treatment through this phase 2 clinical trial at a research site in Galveston. Study-provided care at no cost to qualified participants.

Sponsored by The University of Texas Medical Branch, Galveston

Quick Self-Assessment

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Expert Care in Galveston

Access asthma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related asthma treatment provided free

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Check if you qualify for this asthma clinical trial in Galveston, TX

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Galveston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Galveston site if eligible
  4. 4Begin participation

About This Asthma Study in Galveston

This is a mechanistic, controlled, open-label, single-site study to evaluate the effects of RG-RV16 inoculation on airway mucosal gene expression and airway remodeling in 25 healthy controls (HC), in 25 allergic rhinitis subjects (AR) with cat dander allergy, and in 25 allergic asthmatic subjects (AA) with cat dander allergy. Three groups (HC, AR, and AA) will undergo screening to establish clinical history, will undergo pulmonary function testing (spirometry), and will have blood drawn for clinical characterization (IgE, , ImmunoCAP, CBC and differential), and for assessing the presence of existing neutralizing antibody against RV16. Only those who meet criteria will be permitted to continue into the interventional and run-out phases of the study.

Sponsor: The University of Texas Medical Branch, Galveston

Who Can Participate

Inclusion Criteria

Healthy Normal Control Group
Subject must be able to understand and provide informed consent
Age: 18-60 inclusive
Sex: M or F
No history of asthma, COPD, rhinitis, or other clinically important respiratory disease
Non-smoker, or ex-smoker with \<10 pack years, at least 5 years remote.
No history of diabetes or cardiovascular disease
Negative ImmunoCAP test to regionally relevant allergen panel obtained at Screening. Alternatively, documented history of a negative skin test or negative specific IgE obtained within the past 12 months. Allergic Rhinitis Group
Subject must be able to understand and provide informed consent
Age: 18-60 inclusive
Sex: M or F
No history of asthma, COPD, or other clinically important respiratory disease
Non-smoker, or ex-smoker with \<10 pack years, at least 5 years remote
No history of diabetes or cardiovascular disease
History of rhinitis, physician diagnosed, plus one of the following criteria within the past 12 months
Seasonal or perennial nasal congestion or sneezing
Seasonal or perennial conjunctival infection or watering
No evidence of airway obstruction (FEV1:FVC ≥ lower limit of normal)
Positive ImmunoCAP test to cat. Documented history at any time of a positive skin test or a specific IgE measure at least Level 2 reactivity will meet this criterion. Subjects must have cat in home, have regular exposure to cat dander, or live in a home where a cat has lived within the past 6 months. Allergic Asthma Group Inclusion Criteria
Subject must be able to understand and provide informed consent
Age: 18-60 inclusive
Sex: M or F
No history of COPD or other clinically important respiratory disease other than asthma
Non-smoker, or ex-smoker with \<10 pack years, at least 5 years remote
No history of diabetes or cardiovascular disease
History of mild-moderate asthma, physician diagnosed, plus one of the following criteria within the past 12 months
Airway obstruction (FEV1: FVC \<0.6) that is significantly (at least 12% change from baseline, ATS criteria) reversible after 4 puffs of albuterol (obtained at Screening Visit or documented historical testing performed with the past 12 months)
Requiring ICS for control of asthma for at least 30 days within the past 12 months
Positive ImmunoCAP test to cat dander. Documented history at any time of a positive skin test or a specific IgE measure at least Level 2 reactivity will meet this criteria. Subjects must have cat in home, have regular exposure to cat dander, or live in a home where a cat has lived within the past 6 months.
Results of the CBC do not show clinically important abnormalities

Exclusion Criteria

Healthy Group Normal Group
Inability or unwillingness of a participant to comply with study protocol
Currently taking inhaled corticosteroids, leukotriene modifier, or antihistamines for respiratory disease.
Neutralizing Ab to RV16 greater than or equal to 1:8
Pregnant or breastfeeding women or a woman who has a planned pregnancy during the course of the study. Menstruating females must have a negative pregnancy test at the screening visit. Pregnancy testing may be conducted prior to procedures as well at various times in the study.
Subjects with household or close contacts who are pregnant or planning a pregnancy during the main subject's participation, who have chronic respiratory disease, who are children under the age of 2 years, or who are adults over 60 years of age or are Immunosuppressed e.g. post-chemotherapy, HIV).
Subjects who provide healthcare services or work with elderly or children (e.g. daycare provider, senior citizen care giver). Allergic Rhinitis Group
Inability or unwillingness of a participant to comply with study protocol
Currently using inhaled steroids, or oral montelukast for respiratory disease
Neutralizing Ab to RV16 greater than or equal to 1:8
Pregnant or breastfeeding women or a woman who has a planned pregnancy during the course of the study. Menstruating females must have a negative pregnancy test at screening visit. Pregnancy testing may be conducted prior to procedures as well at various times in the study.
Subjects with household or close contacts who are pregnant or planning a pregnancy during the main subject's participation, who have chronic respiratory disease, who are children under the age of 2 years, or who are adults over 60 years of age or are Immunosuppressed e.g. post-chemotherapy, HIV) .
Subjects who provide healthcare services or work with elderly or children (e.g. daycare provider, senior citizen care giver).
Subjects who have received immunosuppressive treatment within the last 12 months
BMI is greater than 35
History of symptoms consistent with a viral URI within the past 21 days
Results of the CBC do not show clinically important abnormalities
Family history or medical history of liver disease or bleeding disorders
Have not received systemic corticosteroids for 3months prior to Screening
Antiplatelet agents other than aspirin
Subjects who have a positive COVID-19 test will be excluded for 8 weeks Allergic Asthma Group
Inability or unwillingness of a participant to comply with study protocol
Currently taking medications for respiratory diseases other than ICS, montelukast, or rescue albuterol or LABAs.
Neutralizing Ab to RV16 greater than or equal to 1:8
FEV1: FVC ratio less than 0.6, or FEV1 less than 60% predicted
Recent (\<30 days) exacerbation of asthma requiring systemic corticosteroids
ICS greater than fluticasone 500 mcg/day or its equivalent (GINA 2019 table) at screening.
Pregnant or breastfeeding women or a woman who has a planned pregnancy during the course of the study. Menstruating females must have a negative pregnancy test at screening. Pregnancy testing may be conducted prior to procedures as well at various times in the study.
Subjects with household or close contacts who are pregnant or planning a pregnancy during the main subject's participation, who have chronic respiratory disease, who are children under the age of 2 years, or who are adults over 60 years of age or are Immunosuppressed e.g. post-chemotherapy, HIV) .
Subjects who provide healthcare services or work with elderly or children (e.g. daycare provider, senior citizen care giver).
Subjects who have received immunosuppressive treatment within the last 12 months
BMI is greater than 35
History of symptoms consistent with a viral URI within the past 21 days
Family history or medical history of liver disease or bleeding disorders
Have not received systemic corticosteroids for 3 months prior to Screening
Have an ACT score \>19 at the time of enrollment.
Antiplatelet agents other than aspirin
Subjects who have a positive COVID-19 test will be excluded for 8 weeks

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Galveston?

Yes, this clinical trial (NCT05331170) has an active research site in Galveston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Asthma Treatment Options in Galveston, TX

If you're searching for asthma treatment options in Galveston, TX, this clinical trial (NCT05331170) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Galveston research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced asthma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all asthma clinical trials near you to find additional studies recruiting in your area.

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