Charlottesville, VANCT04380038Now EnrollingIRB Ready

Asthma Clinical Trial in Charlottesville, VA

Access cutting-edge asthma treatment through this phase 4 clinical trial at a research site in Charlottesville. Study-provided care at no cost to qualified participants.

Sponsored by University of Virginia

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Expert Care in Charlottesville

Access asthma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related asthma treatment provided free

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Check if you qualify for this asthma clinical trial in Charlottesville, VA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Charlottesville

    Convenient for VA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charlottesville site if eligible
  4. 4Begin participation

About This Asthma Study in Charlottesville

Often when people with asthma get a virus caused by the common cold (rhinovirus), they also experience an increase or worsening of their asthma symptoms. The purpose of this study is to see if the study medication dupilumab helps prevent those with mild to moderate asthma from having increased asthma symptoms, after being exposed to an experimental rhinovirus inoculation. This is a study about dupilumab which is a drug approved by the U.S. Food and Drug Administration (FDA) for treatment of moderate to severe asthma. Dupilumab is a medication that blocks pathways that cause asthmatic inflammation in the lungs, leading to symptoms and worsening lung function. During this study, subjects will be given either dupilumab or placebo and will subsequently be exposed to the the "common" cold virus (rhinovirus). The virus that the investigators are using has been safely used before in many studies like this involving thousands of volunteers, and the safe use of the virus in this research study has been reviewed by the FDA. The investigators will track asthma symptoms during the study with lung function tests, questionnaires, specimen collection, biomarkers, and physical exams. For data analysis the investigators will assess the samples collected to determine changes in the treatment groups. The investigators will also asses the symptom scores and deviations from baseline measures for lung function.

Sponsor: University of Virginia

Who Can Participate

Inclusion Criteria

Adult ages 18-40
Physician diagnosed asthma for at least 6 months
Mild persistent asthma well controlled (ACT≥20) over 6-month period prior to enrollment
FEV1 of \>80% predicted
Well controlled asthma on albuterol alone or albuterol plus low to medium dose inhaled corticosteroids (ICS) with or without other controller medications not using any anti-inflammatory medications for any concurrent sinonasal conditions.
Positive methacholine test (≤16 mg/ml)
Blood eosinophil count ≥150/µL or FeNO ≥20 ppb
Negative (≤1:4) serum neutralizing HRV antibody to HRV 16 or HRV 39.
Willing and able to comply with clinic visits and study-related procedures
Provide informed consent signed by study patient
Able to understand and complete study-related questionnaires

Exclusion Criteria

Current smoker or has smoked regularly for 10 yrs and smoked \>10 pack-years
History or clinical evidence of COPD or any other significant lung disease
Known allergy to any ingredients in the study drug product
Asthma biologic therapy in last 3 months (including dupilumab)
Antiviral, immunosuppressive, or immune modulator therapies in the last 3 months
Use of any inhaled nasal sprays
Upper or lower respiratory tract infection in the last 6 weeks
Asthma exacerbation in the last 6 weeks
Any history of an asthma exacerbation requiring Emergency Department visit, intubation or hospitalization
History of asthma exacerbation requiring unscheduled office visit or oral corticosteroids within the past 3 years
Members of the clinical site study team and/or his/her immediate family
Pregnant or breastfeeding women
Women of childbearing potential\
who are unwilling to practice highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 4 months after the last dose. Highly effective contraceptive measures include:
stable use of combined (estrogen and progestogen containing) hormonal contraception (oral, intravaginal, transdermal) or progestogen-only hormonal contraception (oral, injectable, implantable) associated with inhibition of ovulation initiated 2 or more menstrual cycles prior to screening
intrauterine device (IUD); intrauterine hormone releasing system (IUS)
bilateral tubal ligation
vasectomized partner and/or <!-- -->
sexual abstinence†, ‡.
Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of childbearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation.
Sexual abstinence is considered a highly effective method only if defined as refraining from heterosexual intercourse during the entire period of risk associated with the study treatments.
Periodic abstinence (calendar, symptothermal, post-ovulation methods), withdrawal (coitus interruptus), spermicides only, and lactational amenorrhoea method (LAM) are not acceptable methods of contraception. Female condom and male condom should not be used together.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charlottesville?

Yes, this clinical trial (NCT04380038) has an active research site in Charlottesville, VA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Asthma Treatment Options in Charlottesville, VA

If you're searching for asthma treatment options in Charlottesville, VA, this clinical trial (NCT04380038) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charlottesville research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced asthma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all asthma clinical trials near you to find additional studies recruiting in your area.

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