Is NCT06299592 recruiting in Madison, WI?

Yes, NCT06299592 is currently recruiting participants at its Madison, WI location. This asthma clinical trial is actively enrolling qualified participants.

How do I join the asthma clinical trial in Madison?

To join this clinical trial in Madison, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Madison clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Asthma Clinical Trial in Madison, WI

About This Asthma Study in Madison

The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 3 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test and breathing tests * Give two blood samples * Give a sputum sample * Complete brain imaging scans Researchers will compare results between participants with asthma, and participants who do not have asthma.

Sponsor: University of Wisconsin, Madison

Who Can Participate

Inclusion Criteria

Ability to understand and the willingness to sign a written informed consent document

Individuals with no health concerns that might affect the outcome of the study

Age 18-75 years of age

Ability to tolerate a simulated MRI brain scanning session

In the opinion of the investigator, capable and willing to grant written informed consent and cooperate with study procedures and requirements

High-affinity TSPO-binding genotype. Mixed (high/low) binding-affinity genotype may be included at PIs discretion

For participants with severe asthma:

Physician diagnosis of asthma for at least six months prior to screening (can be determined at the discretion of an asthma/allergy physician member of the study team)

Severe asthmatics must meet the ATS definition of severe asthma and/or be currently receiving a GINA Step 4 or 5 therapy or daily treatment of 320mcg budesonide. Therapy may include ongoing use of currently approved biologic immunomodulators

Exclusion Criteria

Current smoker (defined as more than 0.5 pack per week for the past 6 months and any smoking within two weeks of study procedures) or has a smoking history exceeding 5 pack years within the last 10 years

Currently receiving allergen immunotherapy unless on stable dose.

Use of psychotropic medication that might affect function of neurocircuitry implicated in our hypotheses (at the discretion of the PI/Co-I)

Inability to hold medications detailed in the medication hold schedule

Needle phobia or claustrophobia

Major health problems such any of the following in the last 6 months: stroke/TIA, myocardial Infarction, stent placement, or acute coronary syndrome are definitively exclusionary. Decisions regarding other major health problems, such as autoimmune disease, history of carotid stenosis, heart disease, uncontrolled hypertension, lung diseases other than asthma, history of significant arrhythmias, etc. will be based upon the judgement of the PI/Co-I.

Use of biologic medication that might affect signaling pathways under investigation (at the discretion of the PI/Co-I)

Pre-existing chronic infectious disease

Scheduled use of non-selective beta-blockers prior to each study visit.

Use of an investigational drug within 30 days of entering the study. This criterion will be reviewed on a case by case basis by the PI/Co-I to determine appropriate washout period. Appropriate wash out period may be greater than 30 days depending on the half-life of the investigational drug. Participants may be eligible for study participation after completing the washout period designated by the PI or Co-I (physician only).

Any MRI incompatibility as determined by most current MRI screening form

History of a diagnosed bipolar disorder, schizophrenia, or schizoaffective disorder

History of serious head trauma or seizure disorder (can be included at the discretion of the PI or Co-I)

Unable, in the judgement of the investigator, to comply with directions and/or tolerate the procedures required for participation in this study

Pregnant or breast-feeding or has a planned pregnancy during the course of the study

Any other medical condition or disease that would impact participant safety or data integrity in the opinion of the PI/CO-I

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Madison?

Yes, this clinical trial (NCT06299592) has an active research site in Madison, WI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Asthma Treatment Options in Madison, WI

If you're searching for asthma treatment options in Madison, WI, this clinical trial (NCT06299592) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Madison research site is actively enrolling participants for this clinical trial. You'll receive care from experienced asthma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all asthma clinical trials near you to find additional studies recruiting in your area.

Asthma Clinical Trial in Madison, WI

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