Bethesda, MDNCT06344130Now EnrollingIRB Ready

Astrocytoma Clinical Trial in Bethesda, MD

Access cutting-edge astrocytoma treatment through this phase 1 clinical trial at a research site in Bethesda. Study-provided care at no cost to qualified participants.

Sponsored by National Cancer Institute (NCI)

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Expert Care in Bethesda

Access astrocytoma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related astrocytoma treatment provided free

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Check if you qualify for this astrocytoma clinical trial in Bethesda, MD

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Why Participate?

  • No-Cost Study Care

  • Local to Bethesda

    Convenient for MD residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Bethesda site if eligible
  4. 4Begin participation

About This Astrocytoma Study in Bethesda

Background: Glioblastoma (GBM) is a cancer of the brain. Current survival rates for people with GBM are poor; survival ranges from 5.2 months to 39 months. Most tumors come back within months or years after treatment, and when they do, they are worse: Overall survival drops to less than 10 months. No standard treatment exists for people whose GBM has returned after radiation therapy. Objective: To find a safe schedule for using radiation to treat GBM tumors that returned after initial radiation treatment. Eligibility: People aged 18 years and older with grade 4 GBM that returned after initial radiation treatment. Design: Participants will be screened. They will have a physical exam with blood tests. A sample of tumor tissue may be collected. Participants will undergo re-irradiation planning: They will wear a plastic mask over their head during imaging scans. These scans will pinpoint the exact location of the tumor. This spot will be the target of the radiation treatments. Participants will undergo radiation treatment 4 times per week. Some people will have this treatment for 3 weeks, some for 2 weeks, and some for 1 week. Blood tests and other exams will be repeated at each visit. Participants will complete questionnaires about their physical and mental health. They will answer these questions before starting radiation treatment; once a week during treatment; and at intervals for up to 3 years after treatment ends. Participants will have follow-up visits 1 month after treatment and then every 2 months for 6 months. Follow-up clinic visits will continue up to 3 years. Follow-ups by phone or email will continue an additional 2 years.

Sponsor: National Cancer Institute (NCI)

Who Can Participate

Inclusion Criteria

Histologic diagnosis of primary glioblastoma or gliosarcoma of the brain, or secondary glioblastoma of the brain due to transformation from a lower grade to a grade 4 tumor.
Age \>= 18.
KPS \>= 70%.
Previous tumor irradiation to curative-intent doses.
Radiation dose constraints must be achievable based on assessment with MRI and treatment planning CT.
Participants must have adequate organ and marrow function as defined below:
Absolute neutrophil count (ANC) \>= 1,000/microL
Platelets \>= 100,000/microL
Individuals of child-bearing potential (IOCBP) and individuals who can father children must agree to use effective contraception (barrier, hormonal, intrauterine device, surgical sterilization, abstinence) from study entry and through 6 months after the last study treatment (restricted period). Individuals who can father children must not freeze or donate sperm within the same period.
Nursing participants must be willing to discontinue nursing from study treatment initiation through 6 months after the last study treatment.
The ability of a participant to understand and the willingness to sign a written informed consent document.

Exclusion Criteria

Recent systemic therapy prior to the initiation of the study therapy as follows:
Bevacizumab used for reasons other than tumor progression or symptomatic management within 2 weeks.
Temozolomide within 2 weeks.
Cytotoxic chemotherapy within 3 weeks.
Any investigational agents within 2 weeks.
Participants who are unable to undergo MRI evaluation or receive gadolinium contrast for any reason.
Any prior therapy after surgical re-resection or biopsy within 2 weeks prior to the initiation of the study therapy.
Requiring radiation therapy within 12 months prior to the initiation of study therapy.
History of prior therapy with Novacure TTF, Gliadel wafers, or GammaTile therapy.
Positive beta-human chorionic gonadotropin (HCG) pregnancy test performed in individuals of childbearing potential at screening.
Participants with known or suspected radiation sensitivity syndromes.
Uncontrolled intercurrent illness evaluated by medical history and physical exam that are not stable and would potentially increase the risk to the participant.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Bethesda?

Yes, this clinical trial (NCT06344130) has an active research site in Bethesda, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Astrocytoma Treatment Options in Bethesda, MD

If you're searching for astrocytoma treatment options in Bethesda, MD, this clinical trial (NCT06344130) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Bethesda research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced astrocytoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all astrocytoma clinical trials near you to find additional studies recruiting in your area.

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