Cleveland, OHNCT06802081Now EnrollingIRB Ready

Atrial Fibrillation Clinical Trial in Cleveland, OH

Access cutting-edge atrial fibrillation treatment through this clinical trial at a research site in Cleveland. Study-provided care at no cost to qualified participants.

Sponsored by The Cleveland Clinic

Quick Self-Assessment

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Expert Care in Cleveland

Access atrial fibrillation specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related atrial fibrillation treatment provided free

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Check if you qualify for this atrial fibrillation clinical trial in Cleveland, OH

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Cleveland

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Cleveland site if eligible
  4. 4Begin participation

About This Atrial Fibrillation Study in Cleveland

This is a single center randomized double blind controlled study of patients (BMI ≥ 27 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom severity, and burden of AFIB at 12 months.

Sponsor: The Cleveland Clinic

Who Can Participate

Inclusion Criteria

Subjects eligible for inclusion in this study must meet all of the following criteria:
Sinus rhythm at randomization
Sustained normal sinus rhythm (or)
Normal sinus rhythm at office visit
Age ≥18 to ≤80 years old
BMI ≥ 27 and ≤60 kg/m2
AFIB criteria:
Must be documented by ECG or monitor.
Must have symptomatic AFIB (Atrial Fibrillation).
In terms of types of AFIB, either paroxysmal AFIB or persistent AFIB.
All anti-diabetic medication (including insulin) must be stable for at least 3 months prior to enrollment,
HbA1c ≤10% for patients diagnosed with Type 2 Diabetes Mellitus (T2DM).
Ability and willingness to give themselves the medication, comply with study requirements and provide written informed consent.

Exclusion Criteria

Subjects meeting any of the following criteria are not eligible for inclusion in this study.
AFIB ablation within the last 6 months
Planned ablation prior to 3 months post randomization
Significant cardiac valvular disease with planned cardiac valve intervention/surgery in the next 12 months
Severe uncompensated cardiopulmonary disease
New York Heart Association Class III or IV
Left ventricular ejection fraction \<35% at the time of screening
Hospitalization in the past 6 months for myocardial infarction, unstable angina, stroke, transient ischemic attack, or heart surgery
History of solid organ transplant
Type 1 diabetes mellitus or auto-immune diabetes
Estimated Glomerular Filtration Rate (eGFR) \< 30 mL/min/1.73 m2 at screening or on dialysis
Advanced and decompensated cirrhosis characterized by: presence of fibrosis stage 4 (cirrhosis) in liver biopsy, ascites, hepatic encephalopathy, portal hypertension, or esophageal varices.
Hemoglobin less than 9 g/dL
Current participation or use of investigational therapy or less than 3 months since participation in any drug or device trial.
Liver transaminase level \>300 U/L
Subject reports alcohol use of on average \>2 drinks/day
Presence of active malignancy (except non-melanoma skin cancer)
Life expectancy less than 3 years due to concomitant diseases
Major mental health, psychological disorders, or substance abuse disorders that could disqualify the patient from metabolic surgery
Any condition or major illness that, in the investigator's judgment, places the subject at undue risk by participating in the study
Plans to move outside the primary location of study (Northeast Ohio) within the next 12 months
Any personal or family history of pancreatitis or medullary thyroid cancer or MEN2 (Multiple Endocrine Neoplasia Type 2)
Current use or any use within the last 6 months of GLP-1/DPP4i (Glucagon-Like Peptide-1/Dipeptidyl Peptidase-4 inhibitor) or GIP (Gastric Inhibitory Polypeptide)/GLP-1
Known hypersensitivity to investigational product due to prior use of GLP-1/DPP4i or GIP/GLP-1
Allergy to medical grade tape or adhesive
Pregnant, breast-feeding or plans to become pregnant

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT06802081) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Atrial Fibrillation Treatment Options in Cleveland, OH

If you're searching for atrial fibrillation treatment options in Cleveland, OH, this clinical trial (NCT06802081) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced atrial fibrillation specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all atrial fibrillation clinical trials near you to find additional studies recruiting in your area.

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