Is NCT07625215 recruiting in Maplewood, MN?

Yes, NCT07625215 is currently enrolling participants at its Maplewood, MN location. This atrial fibrillation clinical trial is accepting qualified participants.

How do I join the atrial fibrillation clinical trial in Maplewood?

To join this clinical trial in Maplewood, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Maplewood clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Atrial Fibrillation Clinical Trial in Maplewood, MN: BAY 3670549 (Phase 2)

About This Atrial Fibrillation Study in Maplewood

The main goal of this study is to find out how well BAY 3670549 works, how safe it is, how well people can tolerate it, and how the body handles the medicine. The study will compare BAY 3670549 to a placebo (a dummy treatment with no active medicine) in people with AF who need a treatment called electrical cardioversion. Electrical cardioversion is a procedure that helps the heart return to a normal rhythm. In this study, each participant will get a single intravenous (IV) infusion of either BAY 3670549 or a placebo. Participants will then be observed to see whether the heart rhythm returns to a normal rhythm. If it does not, electrical cardioversion can still be performed as planned. The study will look at how many participants return from AF to a normal rhythm, without needing electrical cardioversion and how long it takes. It will also show how many participants experience medical problems after treatment and how BAY 3670549 move into, through and out of the participants' body. The total duration of the study for an individual participant may be up two months. The findings from this study may contribute to the development of a new treatment option for people with AF.

Sponsor: Bayer

Who Can Participate

Inclusion Criteria

Participant must be 18 to 85 years of age inclusive, at the time of signing the informed consent.

Participant is hemodynamically stable and does not require emergency cardioversion, as determined by the investigator.

Participant has a current episode of atrial fibrillation (AF) ongoing for at least 3 hours and no more than 30 days at the time of randomization.

Participant has an indication for electrical cardioversion of AF, as determined by the investigator according to standard clinical practice and national/institutional guidelines.

At randomization, successful initiation and achievement of therapeutic levels of anticoagulation therapy, as well as completion of imaging evaluation for left atrial thrombi, as appropriate for the duration of the AF episode and risk for the participant according to national guideline and institution-specific routine practice.

BMI within range \[18 - 39.9\] kg/m2.

Contraceptive use by participants or participant partners should be consistent with the study protocol and local regulations regarding the methods of contraception for those participating in clinical studies.

Signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol

Willing and able to comply with the receipt, home use, and return of the continuous ECG recording device, as well as with the participation in scheduled telephone follow-up assessments.

Exclusion Criteria

Current atrial flutter (AFL) or combined AF/AFL

Contraindication for electrical cardioversion on planned treatment day

Documented severely dilated left atrium (left atrial diameter, LAD \>5 cm) measured by any modality within the 6 months prior to screening; if several values are available, the most recent one shall be reported. If left atrium diameter was not measured in the last 6 months or a major cardiovascular event occurred within the last 6 months, a new measurement must be done at screening

Unsuccessful conversion of current AF episode (pharmacologically or electrically)

Known severe valvular heart disease (e.g., severe mitral regurgitation, severe aortic stenosis)

Patients with NYHA Class ≥ III heart failure, or with active management of acute heart failure decompensation on treatment day.

History within the preceding 3 months prior to randomization of any of the following events, or any other significant cardiovascular event as judged by the investigator:

Myocardial infarction

Unstable angina pectoris or other signs of myocardial ischemia

Cardiac surgery

Transcatheter valve replacement

Percutaneous coronary intervention (PCI)

Coronary artery bypass graft (CABG) or other revascularization procedure

Severe renal impairment, i.e., estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m² (using CKD-EPI formula) or requiring dialysis

Severe hepatic impairment, i.e. Child Pugh Class C

Use of anti-arrhythmic class I or III drugs within 5 half-lives before study drug administration (oral amiodarone in the previous 3 months)

Hypertension with SBP ≥ 180 mmHg or hypotension (SBP \< 90 mmHg) at randomization (based on the second BP measurement)

Stressor-associated AF, i.e., in the setting of an acute and reversible stressor (e.g., cardiac surgery, myocarditis, endocarditis, sepsis, pneumonia, etc.). This includes ablation procedure within the preceding one month prior to randomization.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Maplewood?

Yes, this clinical trial (NCT07625215) has an active research site in Maplewood, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Atrial Fibrillation Treatment Options in Maplewood, MN

If you're searching for atrial fibrillation treatment options in Maplewood, MN, this clinical trial (NCT07625215) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Maplewood research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced atrial fibrillation specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all atrial fibrillation clinical trials near you to find additional studies recruiting in your area.

Atrial Fibrillation Clinical Trial in Maplewood, MN

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