Pittsburgh, PANCT06081426Now EnrollingIRB Ready

Bipolar Disorder Clinical Trial in Pittsburgh, PA

Access cutting-edge bipolar disorder treatment through this clinical trial at a research site in Pittsburgh. Study-provided care at no cost to qualified participants.

Sponsored by University of Pittsburgh

Quick Self-Assessment

See if you qualify for this Pittsburgh location

Preparing your pre-screening questions…

Expert Care in Pittsburgh

Access bipolar disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related bipolar disorder treatment provided free

Apply for This Pittsburgh Location

Check if you qualify for this bipolar disorder clinical trial in Pittsburgh, PA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Pittsburgh

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Pittsburgh site if eligible
  4. 4Begin participation

About This Bipolar Disorder Study in Pittsburgh

The investigators aim to examine the effect of the ketogenic diet on brain activity, metabolism, and emotions in adults with Bipolar Disorder (BD).

Sponsor: University of Pittsburgh

Who Can Participate

Inclusion Criteria

All participants:
18-40 years of age
Not following a ketogenic diet BD hypomanic group (n=30):
Meeting sex proportion: 50% female
Meeting diagnosis proportion: 50:50% Bipolar I: Bipolar II (BDI:II) (Diagnostic and Statistical Manual of Mental Disorders 5; DSM-5)
Score greater than 10 on the Young Mania Rating Scale score(YMRS)
BD medications will be allowed as in our previous studies: any combination of atypical antipsychotics, lithium, antidepressants, anxiolytics (common in BD) BD euthymic group (n=30):
Meeting sex proportion: 50% female
Meeting diagnosis proportion: 50:50% BDI:II (DSM-5)
Score less than or equal to 10 on YMRS
BD medications will be allowed as in our previous studies: any combination of atypical antipsychotics, lithium, antidepressants, anxiolytics (common in BD) Healthy Control (HC) Group (n=30):
Sex matched with BD groups
No psychiatric history

Exclusion Criteria

All participants:
Not between 18-40 years of age
History of head injury, neurological, pervasive developmental disorder (e.g. autism), systemic medical disease and treatment (medical records, participant report)
Mini-Mental State Examination score (cognitive state) \<24
Premorbid National Adult Reading Test Intelligent Quotient (NAART IQ) estimate\<85
Visual disturbance: \<20/40 Snellen visual acuity
History of alcohol/substance use disorder (SUD; all substances, including nicotine), and/or illicit substance use (except cannabis) over the last 6 months (SCID-5). Note: lifetime/present cannabis use (at non-abuse (\<3 times in the past month) and non SUD levels) will be allowed, given its common usage in BD and young adults. Cannabis SUD over the last 6 months will not be allowed. Urine tests on scan days will exclude current illicit substance use (except cannabis). Salivary alcohol tests on scan days will exclude intoxicated individuals
MRI exclusion: metallic objects, e.g., surgical implants; claustrophobia; positive pregnancy test for females or self-report pregnancy
Unable to understand English
Conditions related to the pancreas, liver, thyroid or gallbladder.
Taking anticoagulants and/or those with blood dyscrasias (illnesses) who have coagulation disorders (eg, hemophilia) because of the ketomojo finger stick blood tests
Scoring 3 or higher on positive symptom factor questions on the Positive and Negative Syndrome Scale (PANSS) questionnaire (indicative of psychotic symptoms)
Currently following a ketogenic diet
Head circumference larger than 24 inches (62cm) and/or chest circumference larger than 55 inches (139 cm) BD hypomanic group:
Must be meeting sex proportions: not 50% female
Must be meeting diagnosis proportions: not 50:50% BDI:II (DSM-5)
Diagnosis of BD in a manic or euthymic episode
Score 10 or lower on the Young Mania Rating Scale score(YMRS)
Using psychotropic medications other than those allowed in inclusion criteria
Does not have a smartphone with a) iOS version 12.0 or above, or b) Android version 8 and later to use with the Keto-Mojo app BD euthymic group:
Not meeting sex proportion: not 50% female
Not meeting diagnosis proportion: not 50:50% BDI:II
Diagnosis of BD in a depressive, hypomanic, or manic episode
Score greater than 10 on YMRS
Using psychotropic medications other than those allowed in inclusion criteria
Does not have a smartphone with a) iOS version 12.0 or above, or b) Android version 8 and later to use with the Keto-Mojo app Healthy Control (HC) Group
Not sex-matched with BD groups
Has psychiatric history

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Pittsburgh?

Yes, this clinical trial (NCT06081426) has an active research site in Pittsburgh, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Bipolar Disorder Treatment Options in Pittsburgh, PA

If you're searching for bipolar disorder treatment options in Pittsburgh, PA, this clinical trial (NCT06081426) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Pittsburgh research site is actively enrolling participants for this clinical trial. You'll receive care from experienced bipolar disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all bipolar disorder clinical trials near you to find additional studies recruiting in your area.

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