Charlottesville, VANCT06118372Now EnrollingIRB Ready

Bleeding Disorder Clinical Trial in Charlottesville, VA

Access cutting-edge bleeding disorder treatment through this clinical trial at a research site in Charlottesville. Study-provided care at no cost to qualified participants.

Sponsored by University of Virginia

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Expert Care in Charlottesville

Access bleeding disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related bleeding disorder treatment provided free

Apply for This Charlottesville Location

Check if you qualify for this bleeding disorder clinical trial in Charlottesville, VA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Charlottesville

    Convenient for VA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charlottesville site if eligible
  4. 4Begin participation

About This Bleeding Disorder Study in Charlottesville

Adult patients on extracoporeal membrane oxygenation (ECMO) frequently experience bleeding, which is in part caused by acquired von Willebrand syndrome (vWS). Prior in vitro studies have shown that the addition of recombinant von Willebrand Factor (vWF) to ECMO patient blood samples, normalizes platelet adhesion and thrombus formation. This study is a phase I study, where adult ECMO patients with refractory bleeding will be treated with recombinant vWF a single time. The primary objectives are to evaluate the safety, tolerability, and pharmacokinetics of recombinant vWF in adult ECMO patients.

Sponsor: University of Virginia

Who Can Participate

Inclusion Criteria

Adult patients (18 years or greater)
On extracorporeal membrane oxygenation
Major bleeding defined by CTCAE class 3 or greater
Off systemic anticoagulation for at least 4 hours

Exclusion Criteria

Platelet count less than 40 x 109/L
International normalized ratio\> 2.0
Fibrinogen less than 150 mg/dL
Current participation in another clinical trial (interventional)
Heparin induced thrombocytopenia (active)
Acute liver failure, as indicated by bilirubin \>20 mg/dL or new onset hepatic encephalopathy
Patient or legally authorized representative unable to give informed consent
Allergy to recombinant von Willebrand Factor or any component of the product based on prior exposure
Of childbearing age and positive pregnancy test during the same hospital admission, a pregnancy test will be mandatory for all women of child-bearing age
Known congenital or acquired thrombophilia
History of deep venous thrombosis, pulmonary embolism, circuit thrombosis, disseminated intravascular coagulation (DIC), ischemic stroke, ST elevation myocardial infarction (STEMI), or arterial thrombosis in the last 3 months.
History of hypersensitivity to vWF concentrate
Known history of vWF antibodies

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charlottesville?

Yes, this clinical trial (NCT06118372) has an active research site in Charlottesville, VA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Bleeding Disorder Treatment Options in Charlottesville, VA

If you're searching for bleeding disorder treatment options in Charlottesville, VA, this clinical trial (NCT06118372) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charlottesville research site is actively enrolling participants for this clinical trial. You'll receive care from experienced bleeding disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all bleeding disorder clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Charlottesville, VA