Wake Forest, NCNCT04884802Now EnrollingIRB Ready

Blood Pressure Clinical Trial in Wake Forest, NC

Access cutting-edge blood pressure treatment through this clinical trial at a research site in Wake Forest. Study-provided care at no cost to qualified participants.

Sponsored by The University of Texas Health Science Center, Houston

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Expert Care in Wake Forest

Access blood pressure specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related blood pressure treatment provided free

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Check if you qualify for this blood pressure clinical trial in Wake Forest, NC

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Wake Forest

    Convenient for NC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Wake Forest site if eligible
  4. 4Begin participation

About This Blood Pressure Study in Wake Forest

An international randomized trial to test the primary hypothesis that perioperative tight blood pressure management reduces a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis, and death) in the 30 days after major non-cardiac surgery. The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).

Sponsor: The University of Texas Health Science Center, Houston

Who Can Participate

Inclusion Criteria

At least 45 years old;
Scheduled for major noncardiac surgery expected to last at least 2 hours;
Having general anesthesia, neuraxial anesthesia, or the combination;
Expected to require at least overnight hospitalization (planned ICU admission is acceptable);
Are designated ASA physical status 2-4 (ranging from mild systemic disease through severe systemic disease that is a constant threat to life);
Expected to have direct intraoperative blood pressure monitoring with an arterial catheter;
Cared for by clinicians willing to follow the GUARDIAN protocol;
Subject to at least one of the following risk factors:
Age \>65 years;
History of peripheral arterial disease;
History of coronary artery disease;
History of stroke or transient ischemic attack;
Serum creatinine \>175 μmol/L (\>2.0 mg/dl) within 6 months;
Diabetes requiring medication;
Current smoking or 15 pack-year history of smoking tobacco;
Scheduled for major vascular surgery;
Body mass index ≥35 kg/m2;
Preoperative high-sensitivity troponin T \>14 ng/L or troponin I equivalent, defined as ≥15 ng/L (Abbott assay), 19 ng/L (Siemens assay, \[Borges, unpublished\]), or 25% of the 99% percentile for other assays - all within 6 months;
B-type natriuretic protein (BNP) \>80 ng/L or N-terminal B-type natriuretic protein (NTProBNP) \>200 ng/L within six months.

Exclusion Criteria

Are scheduled for carotid artery surgery;
Are scheduled for intracranial surgery;
Are scheduled for partial or complete nephrectomy;
Are scheduled for pheochromocytoma surgery;
Are scheduled for liver or kidney transplantation;
Require preoperative intravenous vasoactive medications;
Have a condition that precludes routine or tight blood pressure management such as surgeon request for relative hypotension;
Require beach-chair positioning;
Have a documented history of dementia;
Have language, vision, or hearing impairments that may compromise cognitive assessments;
Have contraindications to norepinephrine or phenylephrine per clinician judgement;
Have previously participated in the GUARDIAN trial.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Wake Forest?

Yes, this clinical trial (NCT04884802) has an active research site in Wake Forest, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Blood Pressure Treatment Options in Wake Forest, NC

If you're searching for blood pressure treatment options in Wake Forest, NC, this clinical trial (NCT04884802) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Wake Forest research site is actively enrolling participants for this clinical trial. You'll receive care from experienced blood pressure specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all blood pressure clinical trials near you to find additional studies recruiting in your area.

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