Boston, MANCT05013892Now EnrollingIRB Ready

Brain Metastases Clinical Trial in Boston, MA

Access cutting-edge brain metastases treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

Quick Self-Assessment

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Expert Care in Boston

Access brain metastases specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related brain metastases treatment provided free

Apply for This Boston Location

Check if you qualify for this brain metastases clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Brain Metastases Study in Boston

This research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (NTS-WBRT). This research study involves: * NTS-WBRT (normal tissue sparing whole brain radiation therapy) * Memantine standard of care drug

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Any patient with a solid tumor diagnosis and any number of brain metastasis clinically indicated for cranial irradiation with whole brain radiation therapy
Karnofsky Performance Status ≥ 70
Prior stereotactic radiosurgery (SRS) permissible per physician discretion
Prior craniotomy permissible per physician discretion. Protocol radiation therapy should be initiated ≥2 weeks after craniotomy.
Prior partial brain radiation therapy permissible if target volume \< 50% brain and per physician discretion
Expectant \> 6 months survival
Ability to understand and the willingness to sign a written informed consent document.
Fluency in English, able to complete questionnaires and neurocognitive testing
Ability to undergo MRI with gadolinium examination
Ability to return for follow-up examinations throughout the course of this study for a maximum of 2 years after radiation treatment completion
Any prior, concomitant, or post-radiotherapy systemic therapy is permitted at discretion of treating physicians
Negative pregnancy test for premenopausal women

Exclusion Criteria

Leptomeningeal disease (by any one or more of clinical assessment, radiographic assessment, or cerebrospinal fluid study)
Prior whole brain radiation therapy
Pre-existing or current use of memantine or other NMDA antagonists
Known allergy to contrast used in imaging studies and/or inability to have MRI imaging
Uncontrolled intercurrent illness that could significantly affect baseline cognitive function as determined by the enrolling clinician, such as symptomatic congestive heart failure, unstable angina pectoris, prior CVA, significant uncontrolled epilepsy or psychiatric illness/social situations that would limit compliance with study requirements
Pregnant or unwilling to use appropriate contraception to prevent pregnancy during the time of radiation therapy
Concurrent participation in an investigational systemic therapy protocol.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT05013892) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Brain Metastases Treatment Options in Boston, MA

If you're searching for brain metastases treatment options in Boston, MA, this clinical trial (NCT05013892) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced brain metastases specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all brain metastases clinical trials near you to find additional studies recruiting in your area.

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