Philadelphia, PANCT07140172Now EnrollingIRB Ready

Breast Cancer Clinical Trial in Philadelphia, PA

Access cutting-edge breast cancer treatment through this clinical trial at a research site in Philadelphia. Study-provided care at no cost to qualified participants.

Sponsored by University Hospital, Basel, Switzerland

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Expert Care in Philadelphia

Access breast cancer specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related breast cancer treatment provided free

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Check if you qualify for this breast cancer clinical trial in Philadelphia, PA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Philadelphia

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Philadelphia site if eligible
  4. 4Begin participation

About This Breast Cancer Study in Philadelphia

This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of lymphedema two years after randomization.

Sponsor: University Hospital, Basel, Switzerland

Who Can Participate

Inclusion Criteria

at screening:
Written informed consent according to ICH/GCP regulations prior to any trial specific procedures.
Patients ≥ 18 years of age.
Node-positive breast cancer (histologically or cytologically proven both in primary tumor and in lymph node) American Joint Committee on Cancer/ International Union Against Cancer (AJCC/UICC) stage II-III (all molecular subtypes allowed).
Node-positivity detected by imaging and non-palpable (iN+) and confirmed by pathology.
Node-positivity palpable (cN1-3) and confirmed by pathology.
Occult breast cancer is allowed, if biopsy-proven axillary lymphatic metastasis is present.
Eligible for primary ALND or SLN procedure and either:
Newly diagnosed.
Isolated in-breast recurrence or second ipsilateral breast cancer after previous breast conserving surgery and sentinel procedure and at least 3 years disease free and no prior axillary dissection or axillary RT.
Upfront surgery setting.
Most suspicious axillary lymph node clipped. (If clipping is not part of the routine, this should be done after consent of the patient as a study procedure.)
Ability to complete the QoL questionnaires.
WHO performance status 0-2
Adequate condition for general anesthesia, breast cancer surgery and radiotherapy.
Adult patients (≥18 years of age).
Women of child-bearing potential are using effective contraception (condom, diaphragm, intrauterine device), are not pregnant or lactating and agree not to become pregnant during trial treatment (until end of RT) and thereafter during the time recommended by the guidelines - also for adjuvant systemic therapies. A negative pregnancy test before registration is required for all women of child-bearing potential.
Men agree not to father a child during trial treatment and for 6 months afterward.

Exclusion Criteria

at screening:
Stage IV breast cancer.
Clinical N3c breast cancer without axillary disease (clinical N3a and clinical N3b are allowed).
Clinical N2b breast cancer (clinical N2a is allowed).
Contralateral breast cancer within 3 years.
Prior axillary surgery (except prior sentinel node procedure in case of in-breast recurrence).
Prior regional radiotherapy.
Neoadjuvant treatment with the exception of bridging therapy given for less than 3 months.
History of hematologic or primary solid tumor malignancy, unless in remission for at least 3 years from pre-registration with the exception of adequately treated cervical carcinoma in situ or localized non-melanoma skin cancer.
Any other serious underlying medical, psychiatric, psychological, familial or geographical condition, which in the judgment of the investigator may interfere with the planned staging, treatment and follow-up, affect patient compliance or place the patient at high risk from treatment-related complications. Exclusion criteria at randomization (intraoperatively):
Absence of clip in the specimen radiography.
Palpable disease left behind in the axilla after TAS.
No SLN identified in the axilla.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT07140172) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Breast Cancer Treatment Options in Philadelphia, PA

If you're searching for breast cancer treatment options in Philadelphia, PA, this clinical trial (NCT07140172) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced breast cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all breast cancer clinical trials near you to find additional studies recruiting in your area.

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