27 Breast Cancer Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Breast Cancer Studies in Philadelphia

NCT06888388Recruiting

Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple ar...

Philadelphia, PA4,700 participantsSir Mortimer B. Davis - Jewish General Hospital

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NCT05625659Recruiting

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

The over-arching goal of the Contrast-Enhanced Spectral Mammography Imaging Screening Trial (CMIST) is to determine if dual-energy contrast-enhanced spectral mammography (CESM) can detect more cancers...

Philadelphia, PANA2,032 participantsAmerican College of Radiology

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NCT05754658Recruiting

African Cancer Genome: GMD

The goal of this study is to develop a comprehensive characterization of genetic and molecular drivers of breast and prostate cancer in individuals of African ancestry. The study is conducted by the A...

Philadelphia, PA1,500 participantsFox Chase Cancer Center

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NCT07038785Recruiting

Identification of Breast Cancer in Breath Samples Using Trained Detection Dogs

The goal of this study is to find out whether a system that uses trained detection dogs and artificial intelligence (AI) can identify breast cancer from a person's breath. Women who are scheduled to h...

Philadelphia, PA1,204 participantsSpotitEarly

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NCT07140172Recruiting

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Li...

Philadelphia, PANA1,060 participantsUniversity Hospital, Basel, Switzerland

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NCT02732171Recruiting

PENN-Surveillance Markers of Utility for Recurrence After (Neo)Adjuvant Therapy for Breast Cancer

This is a single center, prospective cross-sectional study of women who have completed therapy for primary breast cancer within 5 years of diagnosis and are at increased risk for relapse. Patients wi...

Philadelphia, PANA600 participantsAbramson Cancer Center at Penn Medicine

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NCT05867251Recruiting

Study of AVZO-021 in Patients With Advanced Solid Tumors

This study, the first clinical trial of AVZO-021, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and anti-tumor effects of AVZO-021 in patients...

Philadelphia, PAPHASE1430 participantsAvenzo Therapeutics, Inc.

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NCT06795529Recruiting

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

Many people living with metastatic breast cancer face challenging symptoms and frequent medical visits. At the same time, conversations about personal goals, values, and preferences for care may not a...

Philadelphia, PANA400 participantsMassachusetts General Hospital

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NCT04802759Recruiting

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

This is a Phase Ib/II, open-label, multicenter, randomized umbrella study in participants with breast cancer. The study is designed with the flexibility to open new treatment arms as new treatments be...

Philadelphia, PAPHASE1316 participantsHoffmann-La Roche

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NCT05396612Recruiting

Role of the Immune Environment in Response to Therapy in Breast Cancer

This is an observational case-control study of tissues collected from women with ER+HER2- breast cancers. The immune environments of these cancers will be compared to triple negative and HER2+ breast ...

Philadelphia, PA300 participantsAbramson Cancer Center at Penn Medicine

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NCT05683418Recruiting

A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

The goal of this clinical trial is to evaluate the safety and efficacy of TOS-358 in women with HR+ HER2- metastatic breast cancer whose tumors have a mutation in PIK3CA and who meet all other study e...

Philadelphia, PAPHASE1241 participantsTotus Medicines

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NCT07478016Recruiting

EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients

This is a pilot trial to assess how measures of inflammation are correlated with Social Determinants of Health (SDoH) in breast cancer patients. Expected duration of subject participation is one singl...

Philadelphia, PA200 participantsThomas Jefferson University

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NCT04074720Recruiting

Prospective Breast Cancer Biospecimen Collection

Tissue will be procured during a standard of care procedure the patient will already be scheduled to undergo. A one time blood draw will be performed at this time and an optional rectal swab for biome...

Philadelphia, PA200 participantsThomas Jefferson University

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NCT05898399Recruiting

Study of ART6043 in Advanced/Metastatic Solid Tumors Patients

This interventional study will evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ART6043 as monotherapy or in combination with Olaparib or Niraparib....

Philadelphia, PAPHASE1181 participantsArtios Pharma Ltd

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NCT07067788Recruiting

B.Brilliant Revelation Comparision Study

This is an observational study to evaluate the MAMMOMAT B.brilliant system. All diagnostic decisions are made by the treating radiologist based upon standard of care clinical imaging acquired on FDA a...

Philadelphia, PA100 participantsUniversity of Pennsylvania

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NCT07655934Recruiting

A Mixed-Methods Metabolomics Investigation of Lifestyle and Energy Balance During Breast Cancer Survivorship

The MILES Study is a longitudinal, mixed-methods investigation of urinary biomarkers, energy balance, and lifestyle modifications in diverse women during early breast cancer treatment. The study's ove...

Philadelphia, PANA100 participantsAbramson Cancer Center at Penn Medicine

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NCT04841148Recruiting

Avelumab or Hydroxychloroquine with or Without Palbociclib to Eliminate Dormant Breast Cancer

This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who are found to harbor dissemin...

Philadelphia, PAPHASE296 participantsAbramson Cancer Center at Penn Medicine

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NCT04959474Recruiting

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

This phase II trial studies the effect of calorie reduction while undergoing stereotactic ablative radiation therapy in treating patients with breast cancer. Stereotactic ablative radiation therapy (s...

Philadelphia, PANA80 participantsThomas Jefferson University

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NCT05501704Recruiting

ETHAN - ET for Male BC

This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male...

Philadelphia, PAPHASE260 participantsJose Pablo Leone

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NCT05327608Recruiting

Neoadjuvant Breast Cancer Time Restricted Eating

A phase II study to evaluate an innovative approach of following time restricted eating (TRE) in patients with HER2- negative breast cancer who will start neoadjuvant chemotherapy (NCT) for a new diag...

Philadelphia, PANA55 participantsThomas Jefferson University

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NCT04523857Recruiting

ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer

This is a Phase II randomized, controlled, open label breast cancer clinical trial. 66 patients will be enrolled. The drugs being studied are hydroxychloroquine (Plaquenil) and abemaciclib (also Verze...

Philadelphia, PAPHASE244 participantsAbramson Cancer Center at Penn Medicine

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NCT03863457Recruiting

[18F] F-GLN by PET/CT in Breast Cancer

Patients with known or suspected primary or metastatic breast cancer with one lesion that is 1.0 cm in diameter or greater may be eligible for this study. Patients may participate in this study if the...

Philadelphia, PAPHASE140 participantsAbramson Cancer Center at Penn Medicine

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NCT04434040Recruiting

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

The purpose of this study is to determine if a combination of two drugs sacituzumab govitecan and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulatin...

Philadelphia, PAPHASE240 participantsDana-Farber Cancer Institute

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NCT07319195Recruiting

Window Study of Intratumoral Mitazalimab in Breast Cancer (WINIT-BC)

The goal of this clinical trial is to study the safety, feasibility, histologic and immunological effects of Mitazalimab, a CD40 agonistic antibody, when administered either alone or in combination wi...

Philadelphia, PAEARLY_PHASE132 participantsJennifer Zhang

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NCT07192432Recruiting

Gene Therapy for HER-Positive Cancer (SENTRY-HER2)

This is a Phase 1/2, first-in-human, open-label, dose-escalating and expansion trial designed to assess the safety and efficacy of VNX-202 in patients with HER2 positive cancers....

Philadelphia, PAPHASE127 participantsVironexis Biotherapeutics Inc.

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NCT05659797Recruiting

FES BPET-DBT in Newly Diagnosed Breast Cancer

Patients with newly diagnosed primary estrogen-receptor (ER) positive breast cancer, with at least one breast lesion that is 1.0 cm in diameter or greater, may be eligible for this study. Patients may...

Philadelphia, PAEARLY_PHASE120 participantsAbramson Cancer Center at Penn Medicine

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NCT05964504Recruiting

Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

This is a prospective observational registry for patients with invasive lobular carcinoma (ILC) of the breast. After the first 1cohort is enrolled, the collected data will be utilized to develop an IL...

Philadelphia, PA12 participantsUniversity of California, San Francisco

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About Breast Cancer Clinical Trials in Philadelphia

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 27 breast cancer clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 14,070 participants. Research is being sponsored by Sir Mortimer B. Davis - Jewish General Hospital, American College of Radiology, Fox Chase Cancer Center and 15 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Philadelphia — FAQ

Are there breast cancer clinical trials in Philadelphia?

Yes, there are 27 breast cancer clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 27 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated July 16, 2026 from ClinicalTrials.gov