19 Prostate Cancer Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Prostate Cancer Studies in Philadelphia

NCT04472338Recruiting

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue...

Philadelphia, PA450 participantsUniversity of Washington

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NCT05818683Recruiting

A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer

The purpose of this study is to identify the recommended phase 2 regimen(s) RP2R(s) of pasritamig and combination regimens in Part 1 (dose escalation) and to determine safety at the putative RP2R(s) o...

Philadelphia, PAPHASE1300 participantsJanssen Research & Development, LLC

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NCT05125016Recruiting

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer

This study is researching an investigational drug called REGN4336. Some participants may receive additional investigational drugs in combination with REGN4336. These additional drugs include REGN5678,...

Philadelphia, PAPHASE1228 participantsRegeneron Pharmaceuticals

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NCT06659614Recruiting

Prostate Tissue BioBank

Prostate cancer is also the most common cancer in men with inherited pathogenic variants in BRCA1 and BRCA2. Beyond BRCA1/2, other genes are known to increase the risk of prostate cancer, including AT...

Philadelphia, PA200 participantsAbramson Cancer Center at Penn Medicine

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NCT05804318Recruiting

Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

This trial is a prospective, single-arm, multi-center clinical trial designed to assess whether adaptive radiotherapy with urethral sparing for low to intermediate risk localized prostate cancer will ...

Philadelphia, PANA132 participantsVarian, a Siemens Healthineers Company

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NCT06844383Recruiting

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate

The purpose of this study is to find out whether talazoparib in combination with enzalutamide or talazoparib alone delays cancer progression in people with metastatic castration-resistant prostate can...

Philadelphia, PAPHASE2126 participantsProstate Cancer Clinical Trials Consortium

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NCT05223803Recruiting

TERPS Trial for De Novo Oligometastic Prostate Cancer

This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis....

Philadelphia, PAPHASE2122 participantsUniversity of Maryland, Baltimore

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NCT05487846Recruiting

Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation

This clinical trial evaluates whether having a trained peer navigator helps African American men with prostate cancer that has spread to other parts of the body (metastatic) understand and navigate th...

Philadelphia, PANA120 participantsThomas Jefferson University

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NCT06064149Recruiting

The CArdiovascular Risk Evaluation in Men With Prostate Cancer Study (CARE-PC) Pilot Feasibility Study

The overarching goal of this trial is to develop mechanisms to improve cardiovascular care among such prostate cancer patients receiving ADT by increasing patient awareness of individualized cardiovas...

Philadelphia, PANA100 participantsVivek Narayan

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NCT07219303Recruiting

Adaptive Radiation Therapy for Men With Intermediate- or High-Risk Prostate Cancer

The goal of this clinical trial is to evaluate if adaptive stereotactic body radiation therapy (SBRT) is a safe and effective way to treat prostate cancer in adults. It will assess the safety profile ...

Philadelphia, PANA80 participantsFox Chase Cancer Center

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NCT07140900Recruiting

Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

The main objective of the trial is to evaluate the safety and tolerability of xaluritamig in combination with darolutamide or abiraterone....

Philadelphia, PAPHASE160 participantsAmgen

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NCT06267729Recruiting

Study of AZD0754 in Participants With Metastatic Prostate Cancer

The purpose of this study is to evaluate the safety, tolerability, and antitumour activity of AZD0754 CAR T-cell therapy in participants with metastatic prostate cancer....

Philadelphia, PAPHASE160 participantsAstraZeneca

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NCT07493512Recruiting

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

The primary objective of this trial is to determine the safety profile of xaluritamig at the proposed regimen in adult participants with metastatic castration-resistant prostate cancer (mCRPC)....

Philadelphia, PAPHASE140 participantsAmgen

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NCT06613100Recruiting

Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer

The primary objectives of this study are to evaluate the safety and tolerability of xaluritamig administered as monotherapy or in combination with an oral Gonadotropin-releasing Hormone (GnRH) antagon...

Philadelphia, PAPHASE140 participantsAmgen

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NCT07111507Recruiting

A Study of Tarlatamab for People With Prostate Cancer

The researchers are doing this study to find out whether tarlatamab is an effective treatment for Delta-like Protein 3 (DLL3)-positive prostate cancer that has spread to other parts of your body (meta...

Philadelphia, PAPHASE232 participantsMemorial Sloan Kettering Cancer Center

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NCT05242744Recruiting

FTT PET/CT in Metastatic Prostate Cancer

Up to 30 men with metastatic prostate cancer will undergo up to 2 FTT PET/CT scans to look at PARP activity in sites of known cancer. Subjects will undergo a baseline scan prior to starting new therap...

Philadelphia, PA30 participantsAbramson Cancer Center at Penn Medicine

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NCT06591819Recruiting

Hypofractionated WPPT With HDR Boost

This is a phase II study of ultrahypofractionated whole pelvis proton therapy with brachytherapy boost for patients with high risk or unfavorable intermediate risk prostate with elevated risk of lymph...

Philadelphia, PAPHASE230 participantsAbramson Cancer Center at Penn Medicine

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NCT05627219Recruiting

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread fro...

Philadelphia, PA30 participantsThomas Jefferson University

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NCT06046040Recruiting

TmPSMA-02 in mCRPC

This is a Phase I, open-label dose finding study to assess the safety, tolerability, manufacturing feasibility, and preliminary efficacy of TmPSMA-02 CAR T cells in patients with metastatic castrate-r...

Philadelphia, PAPHASE130 participantsUniversity of Pennsylvania

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About Prostate Cancer Clinical Trials in Philadelphia

Prostate cancer develops in the prostate gland and is one of the most common cancers in men. Many prostate cancers grow slowly, but some can be aggressive. Treatment options range from active surveillance to surgery, radiation, and hormone therapy.

There are currently 19 prostate cancer clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 2,210 participants. Research is being sponsored by University of Washington, Janssen Research & Development, LLC, Regeneron Pharmaceuticals and 11 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Prostate Cancer Clinical Trials in Philadelphia — FAQ

Are there prostate cancer clinical trials in Philadelphia?

Yes, there are 19 prostate cancer clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What prostate cancer treatments are being tested?

The 19 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for prostate cancer.

Data updated July 16, 2026 from ClinicalTrials.gov