San Francisco, CANCT04715568Now EnrollingIRB Ready

Cardiovascular Diseases Clinical Trial in San Francisco, CA

Access cutting-edge cardiovascular diseases treatment through this phase 4 clinical trial at a research site in San Francisco. Study-provided care at no cost to qualified participants.

Sponsored by University of California, San Francisco

Quick Self-Assessment

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Expert Care in San Francisco

Access cardiovascular diseases specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related cardiovascular diseases treatment provided free

Apply for This San Francisco Location

Check if you qualify for this cardiovascular diseases clinical trial in San Francisco, CA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to San Francisco

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit San Francisco site if eligible
  4. 4Begin participation

About This Cardiovascular Diseases Study in San Francisco

This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secondhand tobacco smoke.

Sponsor: University of California, San Francisco

Who Can Participate

Inclusion Criteria

Must be able to understand and provide informed consent.
Adults \>= 40 years of age.
Must have a history of occupational exposure to secondhand tobacco smoke for at least 5 years such as flight attendants who worked for airlines before the smoking ban on aircrafts went into effect or casino workers who worked at casinos with no smoke-free policies.
Must have never smoked or have a remote history of light smoking defined as follows:
Lifetime smoking history equivalent to \< 1 pack-year and
No smoking history for \>= 20 years at the time of enrollment.

Exclusion Criteria

Inability or unwillingness of a participant to give written informed consent or comply with study protocol.
Subject is pregnant, breast-feeding, or plans to become pregnant.
Current therapy with angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB).
Known intolerance to ACE inhibitor or ARB.
History of angioedema.
Conventional indication for ACE inhibitor or ARB (e.g., history of myocardial infarction, known cardiomyopathy).
Blood pressure less than 90 mm Hg systolic or 60 mm Hg diastolic while standing or sitting.
Known unilateral or bilateral renal artery stenosis higher than 70%.
Renal insufficiency (Creatinine Clearance \<30 mL/min by Cockcroft-Gault calculation).
Current regular use of NSAIDs defined as daily use on 5 or more days of the week for more than one month.
Potassium supplementation or serum potassium level of 5.0 milliequivalents (mEq)/dL or higher at V1.
Current use of a potassium sparing diuretic.
History of clinically overt cardiovascular disease including: stable or unstable angina; chest discomfort and dyspnea with baseline exertion; symptomatic coronary artery disease (as defined by history of abnormal stress test; cardiac catheterization showing \>70% coronary artery stenosis; history of revascularization; pathologic Q waves on EKG); poorly controlled resting hypertension (SBP\>160/ DBP\>95); congestive heart failure (CHF) (as defined by left ventricular ejection fraction (LVEF) \<55%; physical exam findings of CHF; symptomatic pulmonary edema); significant (\>mild) valvular heart disease; congenital heart disease; cardiac arrhythmias including frequent premature atrial or ventricular contractions (\>5 per minute).
History of clinically overt pulmonary disease that may interfere with study procedures, including: greater than mild asthma, COPD, emphysema, chronic interstitial lung disease, and pulmonary hypertension.
Neuromuscular disorders or physical disability to perform exercise testing using an ergometer.
Significant history of recreational drug use other than marijuana as defined by: recreational drug use within the last 30 years of recruitment (or) recreational drug use at a frequency of more than once a month before 30 years.
Marijuana use more than once a week.
Other uncontrolled chronic illnesses which in the judgment of the study physician would interfere with completing study procedures.
Failure to keep screening appointments or other indicators of non-adherence.
Concomitant participation in another interventional study.
Subjects with BMI \<15 or \>40 kg/m2.
MRI Scan Participation Exclusion Criteria - The participants will be excluded from the MRI portion of the study if they have a metallic object embedded or implanted in their body that is incompatible with Magnetic Resonance (MR) scanning, including MR incompatible pacemaker or defibrillator.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Francisco?

Yes, this clinical trial (NCT04715568) has an active research site in San Francisco, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Cardiovascular Diseases Treatment Options in San Francisco, CA

If you're searching for cardiovascular diseases treatment options in San Francisco, CA, this clinical trial (NCT04715568) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Francisco research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced cardiovascular diseases specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all cardiovascular diseases clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · San Francisco, CA