NCT04101188 · University of Delaware
Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans
What this study is about
Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.
View original scientific description
Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.
Interventions
OTHER
Moderate Potassium/Low Sodium Diet
Consumption of 10 days of a diet moderate in potassium and low in sodium.
OTHER
Moderate Potassium/High Sodium Diet
Consumption of 10 days of a diet moderate in potassium and high in sodium.
OTHER
High Potassium/High Sodium Diet
Consumption of 10 days of a diet high in potassium and high in sodium.
Primary outcome measures
Conduit artery endothelial-dependent dilation
Time frame: on day 10 of the diet
The change in flow-mediated dilation (FMD) between the 3 diets as assessed by brachial artery FMD
Microvascular function
Time frame: on day 10 of the diet
Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- normal blood pressure
- normal resting ECG
Exclusion criteria
- hypertension
- history of heart disease
- kidney disease
- obese (BMI ≥30)
- significant weight changes in the last 6 months
- use of tobacco products
- on a special diet (gluten free; vegan)
- take any medications for the above conditions
- endurance trained athletes
Where
- Newark, Delaware
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
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Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
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Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 4, 2026 · Source of record for eligibility and locations