NCT05197946 · Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
What this study is about
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP.
View original scientific description
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Individual 8+ years of age
- Diagnosis of cerebral palsy
Exclusion criteria
- -None Neurotypical participants: (Survey-only): Inclusion Criteria:
- Individual 8+ years of age
- Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis Participants with CP (Survey and MRI): Inclusion Criteria:
- Individual 8+ years of age
- Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
- Diagnosis of cerebral palsy
- Clinical imaging demonstrating isolated periventricular white matter injury
- Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury
- Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI Exclusion Criteria: -None Neurotypical participants (Survey and MRI): Inclusion Criteria:
- Individual 8+ years of age
- Adult subject able to indicate understanding and affirmative consent
- Able to lie still in scanner for 1.5 hours and be able to have MRI Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis
Where
- Baltimore, Maryland
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 29, 2026 · Source of record for eligibility and locations