NCT06389721 · M.D. Anderson Cancer Center
Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy
What this study is about
group of participants 1: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN).
View original scientific description
Cohort 1: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN). Cohort 2: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN) and to test a certain type of experimental neuromodulation (stimulation of the brain) with a device called a closed-loop brain-computer interface (clBCI) to see if can help to prevent pain due to CIPN.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Objective 1 Inclusion criteria
- Participants must have the ability to understand and read English, sign a written informed consent, and be willing to follow protocol requirements.
- ECOG Performance Status of 0-2;
- Willing to come to MD Anderson for the imaging sessions.
- Are 18 years of age or above.
- Have a diagnosis of breast cancer.
- will receive chemotherapy including doxorubicin, cyclophosphamide, docetaxel, or paclitaxel; Objective 2 Inclusion criteria: 1\) Inclusion criteria: Identical to Objective 1 and are willing to participate in the therapy sessions at their homes.
Exclusion criteria
- Objective 1 Exclusion criteria:
- Participants who are taking any antipsychotic medications.
- With active CNS disease, such as clinically evident metastases or leptomeningeal disease, dementia, or encephalopathy.
- Have ever been diagnosed with bipolar disorder or schizophrenia.
- Known, previously diagnosed peripheral neuropathy from any causes and
- A history of head injury or who have known seizure activity. Objective 2 Exclusion criteria 1\) Same exclusion criteria as in Objective1. Medication usage will be tracked for patients in all groups. Once prescribed, participants must remain on a stable course of medications throughout the course of chemotherapy.
Where
- Houston, Texas
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 19, 2026 · Source of record for eligibility and locations