Iowa City, IANCT06406777Now EnrollingIRB Ready

Chronic Lung Allograft Dysfunction Lung MRI (CLAD) Clinical Trial in Iowa City, IA

Access cutting-edge chronic lung allograft dysfunction lung mri (clad) treatment through this phase 1/2 clinical trial at a research site in Iowa City. Study-provided care at no cost to qualified participants.

Sponsored by Sean Fain

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Expert Care in Iowa City

Access chronic lung allograft dysfunction lung mri (clad) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic lung allograft dysfunction lung mri (clad) treatment provided free

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Check if you qualify for this chronic lung allograft dysfunction lung mri (clad) clinical trial in Iowa City, IA

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Why Participate?

  • No-Cost Study Care

  • Local to Iowa City

    Convenient for IA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Iowa City site if eligible
  4. 4Begin participation

About This Chronic Lung Allograft Dysfunction Lung MRI (CLAD) Study in Iowa City

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Sponsor: Sean Fain

Who Can Participate

Inclusion Criteria

English Speaking Subjects
Willingness and ability to provide informed consent
Non-smoker Lung transplant patients-inclusion criteria:
\>/= 6 months from lung transplant
History of bilateral lung transplant CLAD-free patients-inclusion criteria:
Stable spirometry with FEV1 \> 90% of baseline value (average of 2 best values) and forced mid-expiratory flow (FEF) (25-75) \> 75% of baseline
Total Lung Capacity (TLC) \> 90 % of baseline
Post-transplant chest radiograph without significant abnormality
No evidence of on-going lung infection or allograft rejection Early CLAD patients-inclusion criteria:
FEV1 \< 80% of baseline value (average of 2 best values)
Follow up 6-months or decline in lung function (20% decrease in FEV1 without evidence of infection or acute rejection)

Exclusion Criteria

SAO2 drops below 90% (in absence of mechanical failure) during normal tidal breathing
Unilateral diaphragm paralysis
Evidence of acute illness on day of study
Evidence of restrictive lung disease
Dependence on supplemental oxygen
History of cardiac disease
Pregnancy (self-declared)
Lactating women
Participants with metal objects in their body
Known contraindication to MRI examination
Systolic blood pressure reading of \< 100 mmHg or \> 200 mmHg
Diastolic blood pressure reading of \<60 mmHg or \> 100 mmHg

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Iowa City?

Yes, this clinical trial (NCT06406777) has an active research site in Iowa City, IA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Lung Allograft Dysfunction Lung MRI (CLAD) Treatment Options in Iowa City, IA

If you're searching for chronic lung allograft dysfunction lung mri (clad) treatment options in Iowa City, IA, this clinical trial (NCT06406777) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Iowa City research site is actively enrolling participants for this phase 1/2 clinical trial. You'll receive care from experienced chronic lung allograft dysfunction lung mri (clad) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic lung allograft dysfunction lung mri (clad) clinical trials near you to find additional studies recruiting in your area.

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