Minneapolis, MNNCT07103135Now EnrollingIRB Ready

Chronic Pain Clinical Trial in Minneapolis, MN

Access cutting-edge chronic pain treatment through this phase 1 clinical trial at a research site in Minneapolis. Study-provided care at no cost to qualified participants.

Sponsored by University of Minnesota

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Expert Care in Minneapolis

Access chronic pain specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic pain treatment provided free

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Check if you qualify for this chronic pain clinical trial in Minneapolis, MN

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Minneapolis

    Convenient for MN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Minneapolis site if eligible
  4. 4Begin participation

About This Chronic Pain Study in Minneapolis

The purpose of this study is to evaluate the safety and efficacy of accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network (AMN) for the treatment of chronic pain. The study will employ Thompson Sampling, a Bayesian reinforcement learning algorithm, to optimize stimulation site selection based on individual response patterns. This approach has the potential to revolutionize pain management by improving treatment accessibility through shortened timelines, addressing individual variations in pain networks through precision targeting, and potentially achieving more robust pain relief through accelerated neuroplasticity. The specific aims of the study are: 1. To establish the relationship between SCAN and AMN connectivity and cognitive- affective pain symptoms. 2. To evaluate the efficacy of Thompson Sampling-optimized aiTBS across SCAN and AMN on affective and sensorimotor pain dimensions. 3. To identify fMRI connectivity biomarkers predictive of treatment response and remission.

Sponsor: University of Minnesota

Who Can Participate

Inclusion Criteria

Ages 18 years or older
Ability to provide written informed consent
Ability to read and to communicate verbally and in writing in English
Chronic pain persisting for at least 12 months
Pain refractory to oral pain medication (defined as failing at least two different medication classes)
Average pain intensity of ≥5 on the Numerical Rating Scale (NRS) over the past two weeks
Stable pain medication regimen for at least 4 weeks prior to enrollment
Willing and able to attend all study visits and comply with study procedures

Exclusion Criteria

Current substance use disorder (except for nicotine or cannabis) as determined by DSM-5 criteria
Active suicidal ideation with intent or plan as determined by the Columbia-Suicide Severity Rating Scale (C-SSRS)
Lifetime history of bipolar disorder, schizophrenia, or other psychotic disorder as determined by medical history
Self-reported unstable medical conditions that would pose increased risks for TMS or MRI
Pregnancy (as determined by urine pregnancy test) or planned pregnancy during the study period
Contraindications to TMS, including:
History of seizure or epilepsy
Metallic implants in the head (excluding dental fillings)
Cardiac pacemaker or other implanted medical devices
History of significant head trauma
History of intracranial surgery
Medication that significantly lowers seizure threshold that cannot be safely held
Contraindications to MRI, including:
Claustrophobia
Metallic implants or devices
Inability to lie flat for the duration of the scan
Current use of high-dose opioids (\>90 morphine milligram equivalents daily)
Participation in another clinical trial of an investigational medication or device within 30 days prior to enrollment
Any condition that, in the investigator\'s opinion, would make it unsafe or difficult for the participant to complete the study

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Minneapolis?

Yes, this clinical trial (NCT07103135) has an active research site in Minneapolis, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Pain Treatment Options in Minneapolis, MN

If you're searching for chronic pain treatment options in Minneapolis, MN, this clinical trial (NCT07103135) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Minneapolis research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced chronic pain specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic pain clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Minneapolis, MN