Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions....
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific append...
Tele-Collaborative Outreach to Rural Patients With Chronic Pain
This is a randomized controlled trial comparing the effectiveness of a remotely delivered collaborative care intervention for chronic pain versus a minimally enhanced control group. The specific aims ...
Proof of Concept Trial of Cannabis Derivatives in Neuropathic Pain
Chronic neuropathic pain (CNP) is disabling. Research on frontline treatments for CNP, shows inconsistent outcomes and dissatisfaction among Veterans. Veterans and clinicians have shown significant in...
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv). The research study is testing two different interventions ...
Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain
A randomized study to determine safety and efficacy of single subcutaneous (SC) administration of HAL treatment in patients with CINP....
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for t...
Low Dose Naltrexone for Pain in Patients With HIV
The increased life expectancy of Patients Living With HIV/AIDS (PLWHA) has increased the need for therapies for chronic conditions, such as chronic pain. Pain in the HIV population is often refractory...
Safety, Efficacy, and Frequency of Administration of VNX001 in the Treatment of Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS)
This is an open-label study that will enroll participants with Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS). The study will assess PRN (as needed) dosing of up to 6 intravesical (via cathet...
Top Cities for Chronic Pain Clinical Trials
Chronic Pain clinical trials are recruiting across 48 cities. Here are the cities with the most active studies:
About Chronic Pain
Chronic pain is pain that persists for more than three months, often beyond the expected healing period. It affects approximately 20% of adults worldwide and can significantly impact quality of life. Management involves a multimodal approach including medications, physical therapy, and interventional procedures.
Clinical trials are advancing new treatments for chronic pain. Currently, 9 studies are recruiting a combined 211,686 participants across the United States. Research is being conducted by 9 organizations including OMNI Medical Services, LLC, Eli Lilly and Company, Oregon Health and Science University and 6 others.
2026 Chronic Pain Research Landscape
As of March 2026, the chronic pain clinical trial landscape includes 9 actively recruiting studies across 48 cities in the United States. These studies are collectively seeking 211,686 participants, with an average enrollment target of 23,521 per study.
Research is being led by 9 different organizations, including OMNI Medical Services, LLC, Eli Lilly and Company, Oregon Health and Science University, VA Office of Research and Development, Erin Winstanley, and 4 others.
Geographically, chronic pain trials are most concentrated in Portland, Oregon (5 trials); Atlanta, Georgia (4 trials); Boston, Massachusetts (3 trials); Birmingham, Alabama (2 trials); Phoenix, Arizona (2 trials) and 7 other cities.
Featured Chronic Pain Studies
Highlighted recruiting studies for chronic pain, selected by enrollment size and research scope.
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Tele-Collaborative Outreach to Rural Patients With Chronic Pain
This is a randomized controlled trial comparing the effectiveness of a remotely delivered collaborative care intervention for chronic pain versus a minimally enhanced control group. The specific aims of the study are: (1) compare the effectiveness of tele-collaborative pain care vs. minimally enhanced usual care to improve pain interference over 12 months of follow-up, and (2) oversample women and...
Frequently Asked Questions About Chronic Pain Clinical Trials
Are there chronic pain clinical trials near me?
Yes, there are 9 chronic pain clinical trials currently recruiting across 48+ cities in the United States, including Portland, Oregon; Atlanta, Georgia; Boston, Massachusetts. Browse the studies above to find one at a location convenient for you.
How do I join a chronic pain clinical trial?
To join a chronic pain clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are chronic pain clinical trials free?
Yes, participation in chronic pain clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of chronic pain treatments are being studied?
Current chronic pain clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 9 research organizations.
Is it safe to participate in chronic pain clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 2, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 2, 2026 · Data from ClinicalTrials.gov