Boston, MANCT07095517Now EnrollingIRB Ready

Colorectal Cancer Prevention Clinical Trial in Boston, MA

Access cutting-edge colorectal cancer prevention treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

Quick Self-Assessment

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Expert Care in Boston

Access colorectal cancer prevention specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related colorectal cancer prevention treatment provided free

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Check if you qualify for this colorectal cancer prevention clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Colorectal Cancer Prevention Study in Boston

This research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk and to understand the feasibility of this precision prevention trial approach for a future larger study.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Age 18-50 years Because no dosing or adverse event data are currently available on the use of tirzepatide in participants \<18 years of age, children are excluded from this study. Because we are specifically studying the prevention of EOCRC, which is defined as CRC occurring prior to age 50, the study population will only enroll participants under the age of 50 at baseline.
BMI between 27 and 40 kg/m2
Underwent a screening or surveillance colonoscopy within the prior 9 months.
Removal of multiple (at least 2) colon or rectal adenomas (including sessile serrated adenomas but excluding hyperplastic polyps) or a single adenoma ≥6mm in size during the last colonoscopy
Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria

Participants who have ever taken incretin mimetic therapies.
Participants with a history of medullary thyroid cancer or MEN 2 syndrome.
Participants at high risk of pancreatitis or otherwise contraindicated for use of tirzepatide according to clinical labeling.
Participants with a history of cancer (excluding non-melanoma skin) within the last three years
Participants with a history of diabetes mellitus
Participants with a history of bowel surgery
Participants with hereditary cancer syndromes, including HNPCC/Lynch syndrome or familial adenomatous polyposis
Participants with a history of inflammatory bowel disease, Crohn's, or colitis.
Participants with incomplete or partial polypectomy during prior colonoscopy.
Participants who are pregnant. Participants who may become pregnant or partners of those who may become pregnant while on study will receive contraception counseling. Participants or partners of those who become pregnant while participating on the study should immediately inform their doctor.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT07095517) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Colorectal Cancer Prevention Treatment Options in Boston, MA

If you're searching for colorectal cancer prevention treatment options in Boston, MA, this clinical trial (NCT07095517) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced colorectal cancer prevention specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all colorectal cancer prevention clinical trials near you to find additional studies recruiting in your area.

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