Tustin, CANCT07210515Now EnrollingIRB Ready

Complex Regional Pain Syndrome Type I Clinical Trial in Tustin, CA

Access cutting-edge complex regional pain syndrome type i treatment through this clinical trial at a research site in Tustin. Study-provided care at no cost to qualified participants.

Sponsored by Ambros Therapeutics, Inc.

Quick Self-Assessment

See if you qualify for this Tustin location

Preparing your pre-screening questions…

Expert Care in Tustin

Access complex regional pain syndrome type i specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related complex regional pain syndrome type i treatment provided free

Apply for This Tustin Location

Check if you qualify for this complex regional pain syndrome type i clinical trial in Tustin, CA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Tustin

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Tustin site if eligible
  4. 4Begin participation

About This Complex Regional Pain Syndrome Type I Study in Tustin

Phase 3 Trial of AMBTX-01 (neridronate) for Complex Regional Pain Syndrome Type 1

Sponsor: Ambros Therapeutics, Inc.

Who Can Participate

Inclusion Criteria

Male or female participant ≥ 18 years of age at time of Screening.
A diagnosis of CRPS-1 according to the clinical Budapest Criteria as recommended by the International Association for the Study of Pain (IASP), as well as no known peripheral nerve injury. Signs and symptoms of CRPS must apply to a single identified affected limb (i.e., arm, hand, wrist, leg, ankle or foot) and must demonstrate asymmetry with respect to the contralateral limb.
Single affected limb at the Screening and Randomization Visits meeting the following warm subtype criteria:
Edema in the affected limb
AND ≥ 2 of the following:
Obvious redness in the affected region relative to the same region on the contralateral limb on inspection
≥ 1°C increase in temperature on the affected limb relative to the contralateral limb
Moderate-to-severe edema
≤ 6 months since the onset of CRPS symptoms relative to the Randomization visit
Increased uptake in the involved limb compared to the contralateral limb on TPBS (phase 2 and/or phase 3) during Screening. A historic scan not older than 3 months prior to Randomization Visit is acceptable, if available and of sufficient quality for a central read.
Women of childbearing potential must:
Be nonpregnant.
Be nonlactating.
Agree to use a highly effective method of contraception and for at least 6 months following last investigational product administration. Exception: Women exclusively engaging in same sex sexual activities are not required to meet this criterion.
Adequate compliance with the eDiary during the screening period.

Exclusion Criteria

A current or prior diagnosis of CRPS Type 2 or CRPS not otherwise specified (CRPS NOS), or whose CRPS has no known inciting event, or CRPS-1 without criteria of the warm subtype at the time of Screening.
≥ 40 points on the Pain Catastrophizing Scale.
Prior use of neridronate or participation in a clinical study where the participant may have received neridronate.
The use of any of the following treatments within the timeframe specified from Randomization Visit:
Within the last 12 months:
IV bisphosphonates
IV immunoglobulin
Within the last 6 months:
Any oral bisphosphonate, denosumab (Prolia®) or receptor activator of nuclear factor kappa B ligand (RANKL) inhibitors (e.g., denosumab biosimilar compounds)
Radiation therapy to the head or neck
Participants currently taking or planning to be treated with prohibited concomitant medications/therapies, or not likely able to follow the protocol restrictions for use of concomitant treatment.
Severely impaired renal function.
Hypocalcemia.
Vitamin D deficiency.
Significant dental findings such as an unhealed tooth extraction site.
Eye inflammation.
Significantly elevated liver-related lab tests or evidence of significant liver disease.
Clinically unstable cardiac disease.
Any known conditions, from 3 months prior to Screening Visit or to the Randomization Visit, that may interfere with the assessment of CRPS-1, CRPS-related pain, safety, or other trial assessments.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Tustin?

Yes, this clinical trial (NCT07210515) has an active research site in Tustin, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Complex Regional Pain Syndrome Type I Treatment Options in Tustin, CA

If you're searching for complex regional pain syndrome type i treatment options in Tustin, CA, this clinical trial (NCT07210515) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Tustin research site is actively enrolling participants for this clinical trial. You'll receive care from experienced complex regional pain syndrome type i specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all complex regional pain syndrome type i clinical trials near you to find additional studies recruiting in your area.

More Pulmonary Embolism Trials in Tustin, CA

See all pulmonary embolism clinical trials recruiting in Tustin — not just this study.

Browse Pulmonary Embolism Trials in Tustin →

Browse More Trials by Condition

Pulmonary Embolism TrialsChronic Pain TrialsMyalgic Encephalomyelitis TrialsAll Conditions →

Ready to Join in Tustin?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Tustin, CA