NCT07400042 · Wake Forest University Health Sciences
Peripheral Venous Pressure (PVP) Trial
What this study is about
The purpose of the study is to determine if there is a reduction in the length of stay and rates of rehospitalization for patients diagnosed with congestive heart failure when physicians are provided daily measurements of peripheral venous pressure versus no daily measurements of peripheral venous pressure.
View original scientific description
The purpose of the study is to determine if there is a reduction in the length of stay and rates of rehospitalization for patients diagnosed with congestive heart failure when physicians are provided daily measurements of peripheral venous pressure versus no daily measurements of peripheral venous pressure.
Interventions
OTHER
peripheral venous pressure measurements
Peripheral venous pressure measures provided to physicians daily up to 8 days, with a research note in the electronic medical record containing standardized recommendations for case also provided daily. Care changes up to clinical provider discretion.
OTHER
standard clinical care
Usual standard clinical care
Primary outcome measures
Length of hospital stay
Time frame: up to day 8
Number of days from admission to discharge
Number of subjects rehospitalized
Time frame: Day 30 post index hospitalization
Number of subjects in each group who have been rehospitalized
Number of subjects rehospitalized
Time frame: Month 6 post index hospitalization
Number of subjects in each group who have been rehospitalized
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patients with minimum 3-month history of Congestive Heart Failure admitted to Aurora St. Luke's Medical Center with acute decompensation
- English speaking only
Exclusion criteria
- Patients who do not already have a peripheral IV line inserted
- Patients whose IV line cannot be transduced
- Patients with current or past vein thrombosis in the arm used to measure the pressure or with history of recurrent (\>1) pulmonary embolism
- Patients with active thrombophlebitis in the arm
- Patients who have experienced a major cardiovascular event (myocardial infarction, stroke, etc.) ≤2 months prior to the admission date
- Patients who have received an implanted cardiac resynchronization device (pacemaker or ICD) ≤3 months prior to admission date
- Patients enrolled in other cardiovascular research studies.
- Patients with a clinical condition that the investigator believes may not allow the patient to complete the study, at the discretion of the investigator. Examples of conditions that may apply include severe stenotic valvular disease, isolated right ventricle failure, precapillary pulmonary hypertension, hypertrophic obstructive cardiomyopathy, implanted left ventricular assist device, history of heart transplantation, clinical diagnosis of cardiogenic shock, any left-to-right shunt
- Patients with congenital heart disease or mechanical right heart valve(s)
- Planned heart surgery and/or coronary intervention during hospitalization
- Patients expected to receive heart transplant within 6 months of admission
- IV cannula smaller than 22G
- Patients who are pregnant and/or lactating
- Patients who are unable to provide informed consent
- Patients who are intubated
Where
- Milwaukee, Wisconsin
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 28, 2026 · Source of record for eligibility and locations