Basking Ridge, NJNCT07091084Now EnrollingIRB Ready

Constipation Clinical Trial in Basking Ridge, NJ

Access cutting-edge constipation treatment through this clinical trial at a research site in Basking Ridge. Study-provided care at no cost to qualified participants.

Sponsored by Memorial Sloan Kettering Cancer Center

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Expert Care in Basking Ridge

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related constipation treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Basking Ridge

    Convenient for NJ residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Basking Ridge site if eligible
  4. 4Begin participation

About This Constipation Study in Basking Ridge

The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but contains no medication. The researchers will also study the effect MZRW has on the gut microbiome. The gut microbiome is a diverse community of microorganisms living in the digestive system, essential for digestion and immune function.

Sponsor: Memorial Sloan Kettering Cancer Center

Who Can Participate

Inclusion Criteria

Age 18 years or greater;
A diagnosis of cancer with no restrictions placed on type of cancer or stage;
Completed surgery, chemotherapy, immunotherapy, and/or radiotherapy, or an investigational therapy at least one month prior to study initiation. Patients on stable doses of hormone therapy or targeted therapies will not be excluded;
Karnofsky functional score of ≥ 60;
Cancer survivors who have met the Rome IV criteria (Table 3) of the symptoms of functional constipation which must include two or more of the following:
Straining more than 25% of defecations.
Lumpy or hard stools (7-point Bristol stool scale 1 or 2) more than 25% of defecations.
Sensation of incomplete evacuation more than one-fourth (25%) of defecations.
Sensation of anorectal obstruction/blockage more than one-fourth (25%) of defecations.
Manual maneuvers to facilitate more than one-fourth (25%) of defecations.
Fewer than three spontaneous bowel movements per week.
Loose stools are rarely present without the use of laxatives.
Insufficient criteria for irritable bowel syndrome.
Patient should be able to understand and complete all study assessments on their own
Patient should be able to understand and provide signed informed consent in English. Table 3. Rome IV criteria for functional constipation FUNCTIONAL CONSTIPATION Diagnostic criteria\
Must include two or more of the following:\*\
Straining during more than ¼ (25%) of defecations
Lumpy or hard stools (Bristol Stool Form Scale 1-2) more than ¼ (25%) of defecations
Sensation of incomplete evacuation more than ¼ (25%) of defecations
Sensation of anorectal obstruction/blockage more than ¼ (25%) of defecations
Fewer than three SBM per week
Manual maneuvers to facilitate more than ¼ (25%) of defecations (e.g., digital evacuation, support of the pelvic floor) 9\. Loose stools are rarely present without the use of laxatives 9. Insufficient criteria for irritable bowel syndrome Note \*Criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis

Exclusion Criteria

Patients who have allergic history to herbs or Chinese medicine;
Clinically significant abnormal liver (2 times the ULN for ALT or AST) and kidney disfunction(eGFR below 59 mL/min/1.73m² ) from recent laboratory test recorded in the medical record (within 2 month);
Patients who have any signs of bowel obstruction, or have high risk of bowel obstruction assessed by their treating physician, including factors such as tumor invasion into abdominal organs, recent abdominal surgery, and prior abdominal radiation therapy;
Patients who are prescribed opioid antagonists including methylnaltrexone, naloxegol and naldemedine for opioid induced constipation and required not to stop the medication;
Women who are pregnant, lactating, or not practicing proper contraception by patient report.Patient's should follow proper contraception guidelines for at least 30 days following last dose of the study drug.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Basking Ridge?

Yes, this clinical trial (NCT07091084) has an active research site in Basking Ridge, NJ that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Constipation Treatment Options in Basking Ridge, NJ

If you're searching for constipation treatment options in Basking Ridge, NJ, this clinical trial (NCT07091084) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Basking Ridge research site is actively enrolling participants for this clinical trial. You'll receive care from experienced constipation specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all constipation clinical trials near you to find additional studies recruiting in your area.

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