Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Constipation Clinical Trials
Constipation clinical trials are recruiting across 56 cities. Here are the cities with the most active studies:
Constipation Trial Phases
30 research organizations are sponsoring constipation trials.
About Constipation
Chronic constipation is a common digestive condition involving infrequent bowel movements or difficulty passing stool. It affects up to 16% of adults worldwide. Treatment includes dietary fiber, fluids, exercise, and medications that promote bowel motility.
Clinical trials are advancing new treatments for constipation. Currently, 41 studies are recruiting a combined 47,177 participants across the United States. Research is being conducted by 30 organizations including BioDelivery Sciences International, Mayo Clinic, National Heart, Lung, and Blood Institute (NHLBI) and 27 others.
2026 Constipation Research Landscape
As of July 2026, the constipation clinical trial landscape includes 41 actively recruiting studies across 56 cities in the United States. These studies are collectively seeking 47,177 participants, with an average enrollment target of 1,151 per study.
The research spans multiple phases of development: 18 studies are in NA, 10 studies are in PHASE2, 4 studies are in PHASE3, 3 studies are in PHASE1, 2 studies are in PHASE4. The presence of Phase 3 trials indicates that some constipation treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 30 different organizations, including BioDelivery Sciences International, Mayo Clinic, National Heart, Lung, and Blood Institute (NHLBI), Ardelyx, Eric Roselli, M. D., and 25 others. The large number of sponsors reflects significant research interest and investment in constipation treatment advancement.
Geographically, constipation trials are most concentrated in Houston, Texas (6 trials); New York, New York (5 trials); Rochester, Minnesota (3 trials); Boston, Massachusetts (3 trials); Winston, Salem-North Carolina (3 trials) and 7 other cities.
Featured Constipation Studies
Highlighted recruiting studies for constipation, selected by enrollment size and research scope.
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced constipation (OIC) medications.
Thoracic Specimen Registry
The purpose of the registry will be to support ongoing research in the etiology, early diagnosis, clinical management, and prognosis of lung cancer and other cancers and diseases of the thorax by developing a complete repository of specimens from patients with thoracic disease including but not limited to suspected lung cancer, mediastinal and pleural tumors, lung transplants and from patients at ...
Genome Transplant Dynamics
Study Description: Heart and lung transplants can save lives, but long-term success is often limited by organ rejection that is hard to detect early. This study is testing a new, non-invasive blood test that looks for small pieces of DNA from the donor organ in the patient s blood. We believe higher levels of this donor DNA may signal early rejection before damage becomes permanent. Hypothesis: ...
Frequently Asked Questions About Constipation Clinical Trials
Are there constipation clinical trials near me?
Yes, there are 41 constipation clinical trials currently recruiting across 56+ cities in the United States, including Houston, Texas; New York, New York; Rochester, Minnesota. Browse the studies above to find one at a location convenient for you.
How do I join a constipation clinical trial?
To join a constipation clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are constipation clinical trials free?
Yes, participation in constipation clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of constipation treatments are being studied?
Current constipation clinical trials are testing a range of approaches across NA (18 studies), PHASE2 (10 studies), PHASE3 (4 studies), PHASE1 (3 studies), PHASE4 (2 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 30 research organizations.
Is it safe to participate in constipation clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 20, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 20, 2026 · Data from ClinicalTrials.gov