Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation of antegrade enema flushes. Subjects wil...
Ribociclib (LEE011) Rollover Study for Continued Access
This study is to allow continued use of ribociclib (LEE011) as single agent or in combination with other investigational treatments in patients benefitting from treatment in an eligible Novartis-spons...
Top Cities for Constipation Clinical Trials
Constipation clinical trials are recruiting across 12 cities. Here are the cities with the most active studies:
About Constipation
Chronic constipation is a common digestive condition involving infrequent bowel movements or difficulty passing stool. It affects up to 16% of adults worldwide. Treatment includes dietary fiber, fluids, exercise, and medications that promote bowel motility.
Clinical trials are advancing new treatments for constipation. Currently, 2 studies are recruiting a combined 115 participants across the United States. Research is being conducted by 2 organizations including Indiana University, Novartis Pharmaceuticals.
2026 Constipation Research Landscape
As of March 2026, the constipation clinical trial landscape includes 2 actively recruiting studies across 12 cities in the United States. These studies are collectively seeking 115 participants, with an average enrollment target of 58 per study.
Research is being led by 2 different organizations, including Indiana University, Novartis Pharmaceuticals.
Geographically, constipation trials are most concentrated in Carmel, Indiana (1 trial); Indianapolis, Indiana (1 trial); Birmingham, Alabama (1 trial); Boston, Massachusetts (1 trial); Ann Arbor, Michigan (1 trial) and 7 other cities.
Featured Constipation Studies
Highlighted recruiting studies for constipation, selected by enrollment size and research scope.
Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation of antegrade enema flushes. Subjects will have their microbiome sequenced prior to placement by obtaining a fecal sample. Pre-antegrade continence enema placement results will be compared to fecal samples obtained at 0, 4, 8 months after pl...
Ribociclib (LEE011) Rollover Study for Continued Access
This study is to allow continued use of ribociclib (LEE011) as single agent or in combination with other investigational treatments in patients benefitting from treatment in an eligible Novartis-sponsored ribociclib (LEE011) study that has reached its primary objective(s) or has been halted for other reasons.
Frequently Asked Questions About Constipation Clinical Trials
Are there constipation clinical trials near me?
Yes, there are 2 constipation clinical trials currently recruiting across 12+ cities in the United States, including Carmel, Indiana; Indianapolis, Indiana; Birmingham, Alabama. Browse the studies above to find one at a location convenient for you.
How do I join a constipation clinical trial?
To join a constipation clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are constipation clinical trials free?
Yes, participation in constipation clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of constipation treatments are being studied?
Current constipation clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 2 research organizations.
Is it safe to participate in constipation clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov