Knoxville, TNNCT07133880Now EnrollingIRB Ready

COPD (Chronic Obstructive Pulmonary Disease) Clinical Trial in Knoxville, TN

Access cutting-edge copd (chronic obstructive pulmonary disease) treatment through this clinical trial at a research site in Knoxville. Study-provided care at no cost to qualified participants.

Sponsored by University of Tennessee Graduate School of Medicine

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Expert Care in Knoxville

Access copd (chronic obstructive pulmonary disease) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related copd (chronic obstructive pulmonary disease) treatment provided free

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Check if you qualify for this copd (chronic obstructive pulmonary disease) clinical trial in Knoxville, TN

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Why Participate?

  • No-Cost Study Care

  • Local to Knoxville

    Convenient for TN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Knoxville site if eligible
  4. 4Begin participation

About This COPD (Chronic Obstructive Pulmonary Disease) Study in Knoxville

The purpose of this study is to compare the effectiveness of inhaled bronchodilators delivered via nebulizers vs. dry powder inhalers (DPIs) in symptomatic participants with Chronic Obstructive Pulmonary Disease (COPD) who have airflow obstruction (FEV1/FVC ≤ 70%) and show significant air trapping (RV ≥ 120% of predicted). The investigators hypothesize that, in patients with symptomatic COPD, therapy with a long-acting anti muscarinic agent/long-acting beta agonist (LAMA/LABA) combination administered by nebulizer will improve hyperinflation (increase in inspiratory capacity and reduction in residual volume) and reduce symptoms related to COPD to a greater extent than LAMA/LABA therapy given by a DPI. The study aims to demonstrate the following: 1. Compare the values of inspiratory capacity (IC) and residual volume (RV) in patients receiving LAMA/LABA by DPI with those receiving LAMA/LABA by nebulizer 2. Compare patient reported outcomes (COPD Assessment Test (CAT score), Baseline/Transition Dyspnea Index (BDI/TDI) and the St. George Respiratory Questionnaire (SGRQ) in symptomatic patients with COPD receiving LAMA/LABA by DPI with those receiving LAMA/LABA by nebulizer

Sponsor: University of Tennessee Graduate School of Medicine

Who Can Participate

Inclusion Criteria

Age \> 40 years
Current smoker or past cigarette smoking history of \> 10 pack-years
Symptoms of COPD (cough, sputum production, shortness of breath)
Modified Medical Research Council Dyspnea Scale (mMRC) score ≥2 or CAT score ≥10 at Screening/Run-in visit
A PIFR \> 30 at screening
FEV1/FVC ratio \< 70% (within the past 12 months)
Residual volume (RV) ≥ 120% predicted (within the past 12 months

Exclusion Criteria

Diagnosis of asthma (Verification via medical record and/or patient report)
Previously diagnosed atrial fibrillation with rapid ventricular response (heart rate \> 110 bpm) or ventricular arrhythmia (ventricular tachycardia) (Verification via medical record and/or patient report)
Acute myocardial infarction within 12 weeks of patient study registration (Verification via medical record and/or patient report)
Acute exacerbation of congestive heart failure (Verification via medical record and/or patient report)
Acute exacerbation of COPD within 8 weeks (Verification via medical record and/or patient report)
Recent (within 8 weeks) h/o eye surgery (Verification via medical record and/or patient report)
Uncontrolled glaucoma (Verification via medical record and/or patient report)
Known diagnosis of liver cirrhosis (Verification via medical record and/or patient report)
Known diagnosis of chronic renal insufficiency (defined as a previous serum creatinine \> 2.5 mg/dL - Verification via medical record and/or patient report)
Intolerance to any of the study drugs
Patients receiving long-term azithromycin
Planned surgery requiring hospital admission within 3 months
Currently enrolled in a pulmonary rehabilitation program
Inability to give informed consent
Pregnant or nursing women or women of childbearing potential not using a medically approved means of contraception (i.e., oral contraceptives, intrauterine devices, diaphragm, or subdermal implants)
Inability to understand instructions or comply with the study protocol
Participation in another investigational drug clinical trial within 30 days of patient study registration Medical history can be confirmed by medical records and/or verbal confirmation from patients. However, Inclusion criteria 6 \& 7 must be verified by a previous PFT report dated within 6 months of screening

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Knoxville?

Yes, this clinical trial (NCT07133880) has an active research site in Knoxville, TN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

COPD (Chronic Obstructive Pulmonary Disease) Treatment Options in Knoxville, TN

If you're searching for copd (chronic obstructive pulmonary disease) treatment options in Knoxville, TN, this clinical trial (NCT07133880) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Knoxville research site is actively enrolling participants for this clinical trial. You'll receive care from experienced copd (chronic obstructive pulmonary disease) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all copd (chronic obstructive pulmonary disease) clinical trials near you to find additional studies recruiting in your area.

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