Boston, MANCT06950294Now EnrollingIRB Ready

Critical Illness Clinical Trial in Boston, MA

Access cutting-edge critical illness treatment through this early phase 1 clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

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Expert Care in Boston

Access critical illness specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related critical illness treatment provided free

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Check if you qualify for this critical illness clinical trial in Boston, MA

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Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Critical Illness Study in Boston

The goal of this clinical trial is to learn the formation and recovery rate of methemoglobin (MetHb) in severely sick patients with pneumonia who receive high doses of inhaled nitric oxide (iNO) therapy at 250 parts per million (ppm), not exceeding 300 ppm. Meanwhile, the benefits of the therapy to treat severely sick patients with pneumonia will be explored. Patients who are 18 years or older, newly diagnosed with pneumonia, and severely sick with requirement of a breathing machine could be included. The main questions it aims to answer are: How does methemoglobin change through the iNO treatment? Does iNO therapy increase the number of patients recovering from pneumonia? Researchers will compare iNO treatment to placebo, which means using the same device as the treatment group without delivering the study drug. Participants will: * Receive iNO treatment starting at 250 ppm, not exceeding 300 ppm, 40 min, every 6 hours, from day 1 to day 5 * Be followed up for 60 days

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

18 years or older
Intubated and mechanically ventilated
Within 72h of diagnosis of community- or hospital-acquired pneumonia
Written informed consent obtained from patients or legally authorized representatives

Exclusion Criteria

Baseline methemoglobin 3% or higher
Genetic diseases including glucose-6-phosphate dehydrogenase deficiency, cytochrome b5 reductase deficiency, sickle cell disease
Oxygen saturation \< 88% on 100% inspired fraction of oxygen
Anemia with hemoglobin \< 7.0 g/dl
Acute cardiogenic shock requiring inotropic or mechanical support with an ejection fraction less than 20%
Receiving inhaled NO therapy or decision to initiate inhaled NO therapy within 24 hours post randomization
A decision to do-not-resuscitate (DNR)
Enrollment in another experimental antimicrobial treatment protocol
Patients for whom follow-up is expected to be impossible

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT06950294) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Critical Illness Treatment Options in Boston, MA

If you're searching for critical illness treatment options in Boston, MA, this clinical trial (NCT06950294) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced critical illness specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all critical illness clinical trials near you to find additional studies recruiting in your area.

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