Is NCT06004115 recruiting in Tulsa, OK?

Yes, NCT06004115 is currently recruiting participants at its Tulsa, OK location. This depression, anxiety clinical trial is actively enrolling qualified participants.

How do I join the depression, anxiety clinical trial in Tulsa?

To join this clinical trial in Tulsa, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Tulsa clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Depression, Anxiety Clinical Trial in Tulsa, OK

About This Depression, Anxiety Study in Tulsa

This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individuals will be recruited who will have a diagnosis of major depressive disorder (MDD) and at least one anxiety disorder (AD) (AD-MDD group), up to 65 participants will have a diagnosis of MDD and no diagnosis of an AD and up to 65 participants will have no diagnosis of MDD and a diagnosis of at least one AD will be enrolled to participate in an two session study to obtain 150 completers (50 per group). All participants will receive a single dose of Lorazepam and placebo (order randomized) taken orally. After the \~2.5 hr screening session, participants will complete two identical \~5 hr experimental sessions, each of which include a 30 min eyeblink startle session and a 1.5 hr functional magnetic resonance imaging (MRI) brain scan session. The total time involved in the study is approximately 10.5 hours. The main questions the study seeks to answer are: * are people with comorbid depression and anxiety different than those with depression alone in terms of their eyeblink startle response to threat? * are people with comorbid depression and anxiety different than those with depression alone in terms of their brain activation in response to threat? * are people with comorbid depression and anxiety different than those with depression alone in terms of their responses to anxiety drugs?

Sponsor: Laureate Institute for Brain Research, Inc.

Who Can Participate

Inclusion Criteria

All subjects:

Female or male sex assigned at birth;

Normal or corrected to normal vision/hearing, as protocol elements may not be valid otherwise;

Fluent English speaker, capable of providing written informed consent MDD and AD-MDD subjects:

Current major depressive episode assessed by clinician with guidance from the MINI;

Minimum score of 55 on PROMIS Depression scale AD and AD-MDD subjects:

Current anxiety disorder (generalized anxiety disorder, panic disorder, agoraphobia and social phobia) assessed by clinician with guidance from the MINI;

Minimum score of 55 on PROMIS Anxiety Scale

Exclusion Criteria

All subjects:

Has uncontrolled, clinically significant neurologic (including seizure disorders): cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, endocrine disease, or psychiatric disorder, or other abnormality, which may impact the ability of the subject to participate or potentially confound the study results;

Reported body mass index (BMI) \> 40;

History of moderate or severe traumatic brain injury, as assessed by a TBI questionnaire;

History of eating disorder or obsessive-compulsive disorder, schizophrenia, schizo-affective disorder, bipolar disorder or any sign of psychosis;

Current post-traumatic stress disorder (PTSD) diagnosis (although history of trauma is allowed);

Current use of medications with major effects on brain function or the fMRI hemodynamic response (e.g., methylphenidate, acetazolamide, excessive caffeine intake \> 1000 mg/day) following an initial list compiled by LIBR but also assessed on a case-by-case basis. Individuals who are currently on medication (antidepressants such as SSRIs, TCAs, SNRIs, and Bupropion) and who have not undergone dose or medication changes over the past 6 weeks will be allowed to participate;

Current benzodiazepine or opiate use;

Moderate to severe current substance use disorder, defined as 5 or more symptoms of the criteria for Substance Use Disorder according to DSM 5;

Drug or alcohol intoxication (based on positive UTOX or breathalyzer test at screening or study session) or reported alcohol/drug withdrawal, last cannabis use must be \>48 hours prior to study session;

Has a risk of suicide according to the Investigator's clinical judgement or per Columbia-Suicide Severity Rating Scale (C-SSRS) or equivalent PhenX instrument, the subject scores "yes" on items 4 or 5 in the Suicidal Ideation section with referent to a 30-day period prior to Screening/Baseline or the subject has had one or more suicidal attempts with reference to a 2-year period prior to Screening;

MRI contraindications;

Is pregnant or lactating or intending to become pregnant before, during, or within 12 weeks after participating in this study; or intending to donate ova during this time-period;

Any subject judged by the Investigator to be inappropriate for the study. MDD subjects:

Current (assessed by clinician with guidance from the MINI) anxiety disorder;

Score of \> 60 on PROMIS Anxiety Scale AD subjects:

Current or past recurrent major depressive episodes assessed by clinician with guidance from the MINI;

Score of \> 60 on PROMIS Depression scale

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Tulsa?

Yes, this clinical trial (NCT06004115) has an active research site in Tulsa, OK that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Depression, Anxiety Treatment Options in Tulsa, OK

If you're searching for depression, anxiety treatment options in Tulsa, OK, this clinical trial (NCT06004115) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Tulsa research site is actively enrolling participants for this clinical trial. You'll receive care from experienced depression, anxiety specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all depression, anxiety clinical trials near you to find additional studies recruiting in your area.

Depression, Anxiety Clinical Trial in Tulsa, OK

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