Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

Genome-wide expression patterns of RNA in tumor samples, normal brainstem tissue and cerebrospinal fluid using Affymetrix gene expression profiling

Time frame: 5 years

Collected tumor and normal samples will potentially be used for RNA genome-wide expression pattern profiling.

Validation of results of the genome-wide analysis

Time frame: 5 years

The molecular analysis done on collected samples will be validated through whole genome sequencing.

Proteomic profiling of tumor, normal brainstem tissue and cerebrospinal fluid

Time frame: 5 years

To obtain full characterization of collected samples, proteomic profiling will be done on tumor and normal samples collected.

Protein expression patterns as assessed by immunohistochemistry and western blot compared to normal brainstem tissue

Time frame: 5 years

Collected tumor and normal samples will have the immunochemistry and western blot compared to assess protein expression variation.

Genome-wide analysis of tumor samples and normal brainstem tissue

Time frame: 5 years

To obtain full characterization of collected samples, whole genome sequencing will be done on tumor and normal samples collected.

In vitro and in vivo molecular analysis of collected samples

Time frame: 5 years

Collected samples will potentially be used for in vitro analysis and generation of animal models of this tumor.

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