Seattle, WANCT07680439Now EnrollingIRB Ready

Diffuse Intrinsic Pontine Glioma Clinical Trial in Seattle, WA

Access cutting-edge diffuse intrinsic pontine glioma treatment through this phase 2 clinical trial at a research site in Seattle. Study-provided care at no cost to qualified participants.

Sponsored by BrainChild Bio, Inc

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Expert Care in Seattle

Access diffuse intrinsic pontine glioma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related diffuse intrinsic pontine glioma treatment provided free

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Check if you qualify for this diffuse intrinsic pontine glioma clinical trial in Seattle, WA

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Why Participate?

  • No-Cost Study Care

  • Local to Seattle

    Convenient for WA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Seattle site if eligible
  4. 4Begin participation

About This Diffuse Intrinsic Pontine Glioma Study in Seattle

This study will evaluate BCB-276, an investigational B7-H3-targeted Chimeric Antigen Receptor (CAR) T cell therapy, in children and young adults with diffuse intrinsic pontine glioma (DIPG). DIPG is a rare and aggressive brain tumor with limited treatment options. CAR T cell therapy uses a patient's own immune cells that are changed in a laboratory to recognize and attack cancer cells. The purpose of this study is to determine whether BCB-276, when given after completion of standard radiation therapy, is safe and can improve survival for patients with DIPG. To participate, individuals must be between 1 and 26 years of age when they join the study, have a diagnosis of DIPG, and enroll for treatment within 6 weeks of completing initial radiation therapy. Participants must not have received prior anti-cancer therapy beyond radiation with or without temozolomide prior to joining this study. BCB-276 is administered intraventricularly (into the fluid around the brain), which requires placement of a catheter for treatment. BCB-276 is given every 2 weeks at a research center over a period of several months (approximately 7-8 months). Participation includes travel to a study site, procedures to support treatment administration, sample collection, and ongoing monitoring for safety and effectiveness, with follow-up visits lasting up to about 2 years.

Sponsor: BrainChild Bio, Inc

Who Can Participate

Inclusion Criteria

Participants must be aged 1 and ≤ 26 years and weigh ≥10kg.
Diagnosis of Diffuse Intrinsic Pontine Glioma (DIPG) based on imaging, with or without biopsy confirmation consistent with high-grade glioma or diffuse midline glioma
Able to tolerate leukapheresis and other study procedures in the opinion of the Investigator.
Central Nervous System (CNS) reservoir catheter present prior to first dose of study drug.
Participant must have completed standard radiation therapy within 6 weeks of enrollment for participation.
Performance Status of ≥ 60; mild to moderate restriction or better. Lansky (under 16 years of age) or Karnofsky (16 years of age or older).
Adequate organ function and overall clinical status to participate, including stable or improving neurologic symptoms.
Participants of childbearing/fathering potential must agree to use highly effective contraception from the time of enrollment through 12 months following the last T cell infusion.
Participants with ventriculoperitoneal (VP) shunts need to have a programable system and be able to tolerate temporary adjustment of the shunt required for study treatment.
Participant must meet all other health and safety criteria defined in the study protocol.
Participant and/or authorized legal representative willing to provide consent/assent for study participation, including participation in the 15-year long term follow up period.

Exclusion Criteria

An individual who meets any of the following criteria will be excluded from participation in this study:
Previous tumor-directed therapy or treatment-directed clinical study other than standard radiation with or without temozolamide.
Evidence of metastatic disease.
Requirement of high or increasing doses of corticosteroids prior to participation.
Severe swallowing difficulties or other significant clinical conditions that may interfere with participation.
Presence of an active malignancy other than DIPG.
Active or uncontrolled human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection based on protocol-required laboratory testing.
Pregnant or breastfeeding.
Presence of any condition that, in the Investigator's opinion, would prohibit the participant from undergoing treatment under this protocol.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Seattle?

Yes, this clinical trial (NCT07680439) has an active research site in Seattle, WA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Diffuse Intrinsic Pontine Glioma Treatment Options in Seattle, WA

If you're searching for diffuse intrinsic pontine glioma treatment options in Seattle, WA, this clinical trial (NCT07680439) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Seattle research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced diffuse intrinsic pontine glioma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all diffuse intrinsic pontine glioma clinical trials near you to find additional studies recruiting in your area.

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