Is NCT06372899 recruiting in Philadelphia, PA?

Yes, NCT06372899 is currently recruiting participants at its Philadelphia, PA location. This e-cigarette use clinical trial is actively enrolling qualified participants.

How do I join the e-cigarette use clinical trial in Philadelphia?

To join this clinical trial in Philadelphia, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Philadelphia clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

E-cigarette Use Clinical Trial in Philadelphia, PA

About This E-cigarette Use Study in Philadelphia

This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instructed to switch (versus smoking cigarettes) over a 6-week period. Relative reductions in biomarkers of exposure will be measured. ECIG- and ONP-associated subjective reward and the reinforcing value of ECIGS and ONPS relative to combustible cigarettes will be assessed as mechanisms.

Sponsor: Abramson Cancer Center at Penn Medicine

Who Can Participate

Inclusion Criteria

Able to communicate fluently in English (i.e. speaking, writing, and reading)

Male and female smokers who are \> 21 years of age and self-report smoking at least 5 cigarettes (menthol and/or non-menthol) per day for at least the last 6 months.

5 or more failed quit attempts and the use of smoking cessation medication on at least one prior attempt.

Have a carbon monoxide (CO) greater than 10 ppm.

Not using any forms of nicotine regularly other than cigarettes

Be willing to switch to e-cigarettes or nicotine pouches for 6 weeks.

Plan to live in the area for the duration of the study.

Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form.

Exclusion Criteria

Smoking Behavior

Regular use of nicotine-containing products other than cigarettes (e.g., chewing tobacco, snuff, snus, cigars, e-cigs, etc.). Regular e-cigarette and nicotine pouch use is defined as greater than 5 days/past 30 days. a. Participants agreeing to abstain from using nicotine-containing products other than cigarettes for the duration of the study will be considered eligible.

Current enrollment or plans to enroll in a smoking cessation program over the duration of the study.

Current use of smoking cessation medication

Provide a CO breath test reading less than 10 ppm at Intake. Alcohol and Drug

History of substance abuse (other than nicotine dependence) in the past 12 months.

Current alcohol consumption that exceeds 20 standard drinks/week.

Current use of recreational drugs (other than nicotine and cannabis)

Breath alcohol reading (BrAC) greater than .000 at Intake. Medical

Women, including all individuals assigned as "female" at birth, who are pregnant, breastfeeding, or planning a pregnancy over the duration of the study period.

Serious or unstable disease within the past year (e.g. cancer, heart disease). Applicable conditions will be evaluated on a case-by-case basis by the Principal Investigator. Psychiatric 1\. Lifetime history of schizophrenia or psychosis. General Exclusion

Past, current, anticipated, or pending enrollment in another research program over the study period that could potentially impact subject safety, study data, and/or the study design as determined by the Principal Investigator.

Any medical condition, illness, disorder, adverse event (AE), or concomitant medication that could compromise participant safety or significantly impact study performance as determined by the Principal Investigator. Subjects may be deemed ineligible for any of the aforementioned reasons at any point throughout the study, as well as during the initial telephone screen.

Significant non-compliance with protocol and/or study design as determined by the Principal Investigator. Subjects may be deemed ineligible at any point throughout the study.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT06372899) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

E-cigarette Use Treatment Options in Philadelphia, PA

If you're searching for e-cigarette use treatment options in Philadelphia, PA, this clinical trial (NCT06372899) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced e-cigarette use specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all e-cigarette use clinical trials near you to find additional studies recruiting in your area.

E-cigarette Use Clinical Trial in Philadelphia, PA

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